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The latest results from a study have shown that an arthritis drug, baricitinib, reduced mortality in patients hospitalised with Covid-19
Cardiovascular research is a major and wide-ranging theme in the Molecular and Clinical Sciences Institute, bringing together researchers from all of our research centres. World-leading researchers in cardiology study sports cardiology and the genetics and pathology of sudden cardiac death. Surgeons lead international studies of how and when to treat life-threatening bulges (aneurysms) in major arteries. In vascular biology, clinicians and cell biologists co-operate to understand the causes and consequences of high blood pressure in pregnancy. Others are analyzing the molecular signals that regulate blood pressure, the processes that initiate blood-clotting, and the molecular basis, mechanisms and diagnosis of a range of genetic disorders of the heart, blood and lymph vessels.
Athletes have an increased risk of sudden cardiac death due to the extreme stress their hearts undergo during strenuous exercise. Our Sports Cardiology Unit is ranked first in the world for its research on athletes’ hearts and their adaptation to exercise. It provides screening for major sporting organizations in the UK.
Roughly 12 people under the age of 35 die unexpectedly each week due to a previously undiagnosed heart condition. Scientists in the Cardiology Clinical Academic Group are at the forefront of national screening programmes aimed at identifying electrical and structural defects that can lead to sudden death. The goal is to improve diagnosis and risk estimation for children and young people susceptible to unexpected death.
Principal Investigators: Angeliki Asimaki, Elijah Behr, Michael Papadakis, Sanjay Sharma, Mary Sheppard, Maite Tome
Researchers in Cardiology and the Genetics Centre are identifying and characterizing a variety of other genetic heart and vascular conditions. These include cardiac disorders like arrhythmias, other diseases of the heart muscle, and coronary artery disease; and aortic disease. Research aims at quicker and more accurate tests for such conditions, and new drug targets for treatment. Our internationally acclaimed lymphovascular research group is making strides in the identification and understanding of variant genes leading to lymphatic disorders, and the clinical uses of this understanding.
Principal investigators: Angeliki Asimaki, Tom Barrick, Bridget Bax, John Camm, Christopher Carroll, Elijah Behr, Ingrid Dumitriu, Atticus Hainsworth, Taigang He, Franklyn Howe, Yalda Jamshidi, Steve Jeffery, Juan Carlos Kaski, Sahar Mansour, Peter Mortimer, Dan Osborn, Pia Ostergaard, Alan Pittman, Lakshmi Ratnam, Giuseppe Rosano, Anan Shtaya, Laura Southgate, Maite Tome
Our surgeons and cardiologists perform highly cited and influential work on topics including heart valve replacement by catheter, and the outcomes of surgery to repair weaknesses (bulges called aneurysms) in the aorta.
Principal investigators: Stephen Brecker, Peter Holt, Kate Stenson, James Spratt
The Vascular Biology and Cell Biology Centres house fundamental research on the signals that regulate blood pressure, and the way that blood vessel lining cells initiate the process of blood clotting. Scientists also collaborate with St George’s Trust clinicians in fetal medicine, working on how the placenta can be involved in high blood pressure in pregnancy, and the causes of insufficient growth of the developing baby.
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