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Pregnancy outcomes for mothers and babies have worsened during the Covid-19 pandemic, according to a review led by St George’s Professor Asma Khalil.
The Genetics Research Centre, led by co-heads Dr Pia Ostergaard and Dr Yalda Jamshidi, forms part of the Molecular and Clinical Sciences Research Institute. The centre has 11 principal investigators and their groups, with associate members from across the university and trust. We study the impact of variation in the genome on disease susceptibility. Our research also goes hand-in-hand with undergraduate and postgraduate teaching at the university.
We are interested in investigating the role of mutations in DNA on development and disease. We explore the function of disease associated genes using cutting edge technologies and biological models. We use multiple types of 'omics' data, including genomics, transcriptomics and proteomics to learn more about disease mechanisms. Bioinformatics is integral to our analyses, benefitting in this Centre from the expertise of Dr Alan Pittman.
Our research groups collaborate with clinicians in St George’s University Hospitals NHS Foundation Trust and aim to develop translational, bench-to-bedside approaches. The university and the trust are actively involved in the 100,000 Genomes Project, and the academic and clinical staff are members of the Genomics England Clinical Interpretation Partnership (GeCIP). These projects have the potential to transform the future of healthcare by improving the prediction and prevention of disease, enabling new and more accurate diagnostic tests and allowing the personalisation of drugs and treatments to specific gene variants.
We analyse genomic data in human populations to identify genes associated with traits and diseases.
We aim to identify new genes to help improve our understanding of the mechanistic basis of human diseases.
We are using both in vitro (cell) and in vivo (zebrafish) models to characterise our genetic findings.
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