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2021

 

Anton-Vazquez V, Hine P, Krishna S, Chaplin M, Planche T. Rapid versus standard antimicrobial susceptibility testing to guide treatment of bloodstream infection. Database Syst Rev. 2021 May. PMID: 34097767 

 

Pernaute-Lau L, Adegnika AA, Zhou Y, Zinsou JF, Gil JP, Krishna S, Kremsner PG, Lauschke VM, Velavan TP. Pharmacogene sequencing of a Gabonese population with severe Plasmodium falciparum malaria reveals multiple novel variants with putative relevance for antimalarial treatment. Antimicrob Agents Chemother. 2021 Apr. PMID: 33875422

 

Gabor JJ, Kreidenweiss A, Weber S, Salama M, Sulyok M, Sulyok Z, Koehne E, Esen M, Kreuels B, Shamsrizi P, Biecker E, Mordmüller B, Berg CP, Fusco S, Köhler C, Kubicka S, Leitlein J, Addo M, Ramharter M, Schwab M, Bissinger AL, Velavan TP, Krishna S, Kremsner PG. A call to caution when hydroxychloroquine is given to elderly patients with COVID-19. Int J Infect Dis. 2021 Apr. PMID: 33848675 

 

Brown L, Byrne RL, Fraser A, Owen SI, Cubas-Atienzar AI, Williams CT, Kay GA, Cuevas LE, Fitchett JRA, Fletcher T, Garrod G, Kontogianni K, Krishna S, Menzies S, Planche T, Sainter C, Staines HM, Turtle L, Adams ER. Self-sampling of capillary blood for SARS-CoV-2 serology. Sci Rep. 2021 Apr.PMID: 33833246 

 

Adams ER, Wolday D, Denkinger CM, Krishna S, de Wit TFR.J Glob Health. Scaled testing for COVID-19 needs community involvement. 2021 Mar. PMID: 33763209 

 

Zaloumis SG, Whyte JM, Tarning J, Krishna S, McCaw JM, Cao P, White MT, Dini S, Fowkes FJI, Maude RJ, Kremsner P, Dondorp A, Price RN, White NJ, Simpson JA. Development and validation of an in silico decision-tool to guide optimisation of intravenous artesunate dosing regimens for severe falciparum malaria patients. Antimicrob Agents Chemother. 2021 Mar. PMID: 33685888

 

Pejoski D, de Rham C, Martinez-Murillo P, Santoro F, Auderset F, Medaglini D, Pozzi G, Vono M, Lambert PH, Huttner A, Haks MC, Ottenhoff THM, Villard J, Siegrist CA; VEBCON Consortium; VSV-EBOVAC Consortium; VSV-EBOPLUS Consortium. Rapid dose-dependent Natural Killer (NK) cell modulation and cytokine responses following human rVSV-ZEBOV Ebolavirus vaccination. NPJ Vaccines. 2020 Apr. PMID: 33580050

 

Vanesa AV, Cristina S, Krishna S, Timothy P. Factors influencing antimicrobial prescription attitudes in bloodstream infections: susceptibility results and beyond. An exploratory survey. J Hosp Infect. 2021 Feb, PMID: 33581245.

 

Krishna S, Augustin Y, Wang J, Xu C, Staines HM, Platteeuw H, Kamarulzaman A, Sall A, Kremsner P. Repurposing Antimalarials to Tackle the COVID-19 Pandemic.Trends Parasitol. 2021 Jan, PMID: 33541791

 

Velavan TP, Kieu Linh LT, Kreidenweiss A, Gabor J, Krishna S, Kremsner PG. Longitudinal Monitoring of Lactate in Hospitalized and Ambulatory COVID-19 Patients. Am J Trop Med Hyg. 2021 Jan 11. PMID: 33432902.

 

Ackerman H, Olola CHO, Krishna S, Roberts DJ, Kremsner PG, Newton CR, Taylor T, Valim C, Casals-Pascual C. Time-to-death is a potential confounder in observational studies of blood transfusion in severe malaria - Authors' reply. Lancet Haematol. 2021 Jan, PMID: 33357473.

 

Staines HM, Kirwan DE, Clark DJ, Adams ER, Augustin Y, Byrne RL, Cocozza M, Cubas-Atienzar AI, Cuevas LE, Cusinato M, Davies BMO, Davis M, Davis P, Duvoix A, Eckersley NM, Forton D, Fraser AJ, Garrod G, Hadcocks L, Hu Q, Johnson M, Kay GA, Klekotko K, Lewis Z, Macallan DC, Mensah-Kane J, Menzies S, Monahan I, Moore CM, Nebe-von-Caron G, Owen SI, Sainter C, Sall AA, Schouten J, Williams CT, Wilkins J, Woolston K, Fitchett JRA, Krishna S, Planche T. IgG Seroconversion and Pathophysiology in Severe Acute Respiratory Syndrome Coronavirus 2 Infection. Emerg Infect Dis. 2021 Jan; PMID: 33256890

 

Krishna S, Augustin Y, Wang J, Xu C, Staines HM, Platteeuw H, Kamarulzaman A, Sall A, Kremsner P. Repurposing Antimalarials to Tackle the COVID-19 Pandemic. Trends Parasitol. 2021 Jan; PMID: 33153922

2020

Bone JN, Pickerill K, Woo Kinshella ML, Vidler M, Craik R, Poston L, Stones W, Sevene E, Temmerman M, Koech Etyang A, Roca A, Russell D, Tribe RM, von Dadelszen P, Magee LA; PRECISE Network. Pregnancy cohorts and biobanking in sub- Saharan Africa: a systematic review. BMJ Glob Health. 2020 Nov; PMID: 33243854

 

Ackerman H, Ayestaran A, Olola CHO, Jallow M, Agbenyega T, Bojang K, Roberts DJ, Krishna S, Kremsner PG, Newton CR, Taylor T, Valim C, Casals-Pascual C. The effect of blood transfusion on outcomes among African children admitted to hospital with Plasmodium falciparum malaria: a prospective, multicentre observational study. Lancet Haematol. 2020 Nov; PMID: 33091354.

 

Augustin Y, Staines HM, Krishna S. Artemisinins as a novel anti-cancer therapy: Targeting a global cancer pandemic through drug repurposing. Pharmacol Ther. 2020 Dec; PMID: 33075360; PMCID: PMC7564301.

 

Baker EH, Patel K, Ball J, Edwards S, Harrison TS, Kaul A, Koh M, Krishna S, Leaver S, Kumar V, Forton DM.Insights from compassionate use of tocilizumab for COVID-19 to inform appropriate design of randomised controlled trials.Br J Clin Pharmacol. 2020 Jul 12. PMID: 32656822 

 

 Craik R, Russell D, Tribe RM, Poston L, Omuse G, Okiro P, Chege D, Diatta M, Sesay AK, Cuamba I, Carrilho C, Sevene E, Flint-O'Kane M, von Dadelszen P; PRECISE Network. PRECISE pregnancy cohort: challenges and strategies in setting up a biorepository in sub-Saharan Africa Reprod Health.2020 Apr. PMID: 32354368  

 

Magee LA, Strang A, Li L, Tu D, Tumtaweetikul W, Craik R, Daniele M, Etyang AK, D'Alessandro U, Ogochukwu O, Roca A, Sevene E, Chin P, Tchavana C, Temmerman M, von Dadelszen P; PRECISE Network. The PRECISE (PREgnancy Care Integrating translational Science, Everywhere) database: open-access data collection in maternal and newborn health. Reprod Health. 2020 Apr. PMID: 32354365  

 

Daniele MAS, Martinez-Alvarez M, Etyang AK, Vidler M, Salisbury T, Makanga PT, Musitia P, Flint-O'Kane M, Brown TW, Diallo BA, Boene H, Stones W, von Dadelszen P, Magee LA, Sandall J; PRECISE Network. The contribution of qualitative research within the PRECISE study in sub-Saharan Africa. Reprod Health. 2020 Apr. PMID: 32354359 

 

Flint-O'Kane M, von Dadelszen P, Makanga PT, Sevene E, Roca A, Dukes P, Hinrichs-Krapels S, Craik R, Magee LA, Temmerman M; PRECISE Network. Harnessing the PRECISE network as a platform to strengthen global capacity for maternal and child health research in sub-Saharan Africa. Reprod Health. 2020 Apr. PMID: 32354358  

 

von Dadelszen P, Flint-O'Kane M, Poston L, Craik R, Russell D, Tribe RM, d'Alessandro U, Roca A, Jah H, Temmerman M, Koech Etyang A, Sevene E, Chin P, Lawn JE, Blencowe H, Sandall J, Salisbury TT, Barratt B, Shennan AH, Makanga PT, Magee LA; PRECISE Network. The PRECISE (PREgnancy Care Integrating translational Science, Everywhere) Network's first protocol: deep phenotyping in three sub-Saharan African countries. Reprod Health. 2020 Apr .PMID: 32354357 

 

Pejoski D, de Rham C, Martinez-Murillo P, Santoro F, Auderset F, Medaglini D, Pozzi G, Vono M, Lambert PH, Huttner A, Haks MC, Ottenhoff THM, Villard J, Siegrist CA; VEBCON Consortium; VSV-EBOVAC Consortium; VSV-EBOPLUS Consortium. Rapid dose-dependent Natural Killer (NK) cell modulation and cytokine responses following human rVSV-ZEBOV Ebolavirus vaccination. NPJ Vaccines. 2020 Apr. eCollection 2020. PMID: 32337075  

 

Jigang Wang, Chengchao Xu, Yin Kwan Wong, Yingke He, Ayôla A Adegnika, Peter G Kremsner, Selidji T Agnandji, Amadou A Sall, Zhen Liang, Chen Qiu, Fu Long Liao, Tingliang Jiang, Sanjeev Krishna, Youyou Tu. Preparedness is essential for malaria-endemic regions during the COVID-19 pandemic. Lancet. 2020 Mar. PMID: 32192582

2019

Clark DJ, Moore CM, Flanagan M, Bocxlaer KV, Piperaki ET, Yardley V, Croft SL, Tyson J, Whitehouse SP, O'Halloran J, Krishna S, Staines HM.An efficient and novel technology for the extraction of parasite genomic DNA from whole blood or culture. Biotechniques. 2019 Nov. PMID: 31774301


Wang J, Xu C, Liao FL, Jiang T, Krishna S, Tu Y. Suboptimal dosing triggers artemisinin partner drug resistance. Lancet Infect Dis. 2019 Nov. PMID:31657775 

 

Krishna S. Triple artemisinin-containing combination anti-malarial treatments should be implemented now to delay the emergence of resistance: the case against. Malar J. 2019 Oct. PMID: 31581951 

 

Wang J, Krishna S, Xu C. A Temporizing Solution to "Artemisinin Resistance". Reply. N Engl J Med. 2019 Sep PMID: 31483980 

 

Wang J, Xu C, Liao FL, Jiang T, Krishna S, Tu Y. A Temporizing Solution to "Artemisinin Resistance". N Engl J Med. 2019 May PMID: 31018065 

 

Wallbank BA, Dominicus CS, Broncel M, Legrave N, Kelly G, MacRae JI, Staines HM, Treeck M. Characterisation of the Toxoplasma gondii tyrosine transporter and its phosphorylation by the calcium-dependent protein kinase 3. Mol Microbiol. 2019 May PMID: 30402958 

 

Poetsch JH, Dahlke C, Zinser ME, Kasonta R, Lunemann S, Rechtien A, Ly ML, Stubbe HC, Krähling V, Biedenkopf N, Eickmann M, Fehling SK, Olearo F, Strecker T, Sharma P, Lang KS, Lohse AW, Schmiedel S, Becker S; VSV-Ebola Consortium (VEBCON) , Addo MM. Detectable Vesicular Stomatitis Virus (VSV)-Specific Humoral and Cellular Immune Responses Following VSV-Ebola Virus Vaccination in Humans. J Infect Dis. Jan 2019, PMID: 30452666 

2018

Nsanzabana C, Ariey F, Beck HP, Ding XC, Kamau E, Krishna S, Legrand E, Lucchi N, Miotto O, Nag S, Noedl H, Roper C, Rosenthal PJ, Schallig HDFH, Taylor SM, Volkman SK, Gonzalez IJ. Molecular assays for antimalarial drug resistance surveillance: A target product profile.PLoS One. 2018 Sep., eCollection 2018. PMID: 30235327 

 

Lee AH, Dhingra SK, Lewis IA, Singh MK, Siriwardana A, Dalal S, Rubiano K, Klein MS, Baska KS, Krishna S, Klemba M, Roepe PD, Llinás M, Garcia CRS, Fidock DA. Evidence for Regulation of Hemoglobin Metabolism and Intracellular Ionic Flux by the Plasmodium falciparum Chloroquine Resistance Transporter. Sci Rep. 2018 Sep. PMID: 30206341  

 

Huttner A, Agnandji ST, Combescure C, Fernandes JF, Bache EB, Kabwende L, Ndungu FM, Brosnahan J, Monath TP, Lemaître B, Grillet S, Botto M, Engler O, Portmann J, Siegrist D, Bejon P, Silvera P, Kremsner P, Siegrist CA; VEBCON; VSV-EBOVAC; VSV-EBOPLUS Consortia. Determinants of antibody persistence across doses and continents after single-dose rVSV-ZEBOV vaccination for Ebola virus disease: an observational cohort study. Lancet. Jul. 2018. PMID: 29627147 

 

Clark DJ, Tyson J, Sails AD, Krishna S, Staines HM. The current landscape of nucleic acid tests for filovirus detection. J Clin Virol. Jun. 2018, PMID: 29625392 

 

Bassat Q, Krishna S. Widening the options for recurrent malaria.Lancet. Apr. 2018. PMID: 29606365

2017

Staines HM, Burrow R, Teo BH, Chis Ster I, Kremsner PG, Krishna S. Clinical implications of Plasmodium resistance to atovaquone/proguanil: a systematic review and meta-analysis. J Antimicrob Chemother. 2017 Dec 11, PMID: 29237012 

 

Agnandji ST, Fernandes JF, Bache EB, Obiang Mba RM, Brosnahan JS, Kabwende L, Pitzinger P, Staarink P, Massinga-Loembe M, Krähling V, Biedenkopf N, Fehling SK, Strecker T, Clark DJ, Staines HM, Hooper JW, Silvera P, Moorthy V, Kieny MP, Adegnika AA, Grobusch MP, Becker S, Ramharter M, Mordmüller B, Lell B; VEBCON Consortium, Krishna S, Kremsner PG. Safety and immunogenicity of rVSVΔG-ZEBOV-GP Ebola vaccine in adults and children in Lambaréné, Gabon: A phase I randomised trial. PLoS Med. 2017 Oct., PMID: 28985239 

 

Rechtien A, Richert L, Lorenzo H, Martrus G, Hejblum B, Dahlke C, Kasonta R, Zinser M, Stubbe H, Matschl U, Lohse A, Krähling V, Eickmann M, Becker S; VEBCON Consortium, Thiébaut R, Altfeld M, Addo MM. Systems Vaccinology Identifies an Early Innate Immune Signature as a Correlate of Antibody Responses to the Ebola Vaccine rVSV-ZEBOV. Cell Rep. 2017 Aug., PMID: 28854372 

 

Wang J, Zhang J, Shi Y, Xu C, Zhang C, Wong YK, Lee YM, Krishna S, He Y, Lim TK, Sim W, Hua ZC, Shen HM, Lin Q.Mechanistic Investigation of the Specific Anticancer Property of Artemisinin and Its Combination with Aminolevulinic Acid for Enhanced Anticolorectal Cancer Activity. ACS Cent Sci. 2017 Jul 26 Epub 2017 Jun 28. PMID: 28776016  

 

Meireles P, Mendes AM, Aroeira RI, Mounce BC, Vignuzzi M, Staines HM, Prudêncio M. Uptake and metabolism of arginine impact Plasmodium development in the liver. Sci Rep. 2017 Jun PMID: 28642498 Efferth T, Schöttler U, Krishna S, Schmiedek P, Wenz F, Giordano FA. Answer to the comment of Hai Lu et al. regarding "Hepatotoxicity by combination treatment of temozolomide, artesunate and Chinese herbs in a glioblastoma multiforme patient: case report and review of the literature. Arch Toxicol (2016)". Arch Toxicol. 2017 Jun; PMID: 28317071 

 

Nguetse CN, Adegnika AA, Agbenyega T, Ogutu BR, Krishna S, Kremsner PG, Velavan TP. Molecular markers of anti-malarial drug resistance in Central, West and East African children with severe malaria. Malar J. 2017 May PMID: 28535801 

 

Gil JP, Krishna S. Pfmdr1 (Plasmodium falciparum multidrug resistance gene 1): a pivotal factor in malaria resistance to artemisinin combination therapies. (2017) Expert Review in Anti Infective Therapies. Apr 10:1-17. PMID: 28355493 

 

Dahlke C, Kasonta R, Lunemann S, Krähling V, Zinser ME, Biedenkopf N, Fehling SK, Ly ML, Rechtien A, Stubbe HC, Olearo F, Borregaard S, Jambrecina A, Stahl F, Strecker T, Eickmann M, Lütgehetmann M, Spohn M, Schmiedel S, Lohse AW, Becker S, Addo MM; VEBCON Consortium. Dose-dependent T cell dynamics and cytokine cascade following rVSV-ZEBOV immunization. EBioMedicine. 2017 Apr 5. pii: S2352-3964(17)30141-X PMID: 28434944 

 

Huttner A, Combescure C, Grillet S, Haks MC, Quinten E, Modoux C, Agnandji ST, Brosnahan J, Dayer JA, Harandi AM, Kaiser L, Medaglini D, Monath T; VEBCON and VSV-EBOVAC Consortia., Roux-Lombard P, Kremsner PG, Ottenhoff TH, Siegrist CA. (2017). A dose-dependent plasma signature of the safety and immunogenicity of the rVSV-Ebola vaccine in Europe and Africa. Sci Transl Med. 2017 Apr 12;9(385). PMID: 28404856 

 

Efferth T, Schöttler U, Krishna S, Schmiedek P, Wenz F, Giordano FA. Hepatotoxicity by combination treatment of temozolomide, artesunate and Chinese herbs in a glioblastoma multiforme patient: case report review of the literature.Arch Toxicol. 2017 Apr PMID: 27519711 

 

Meireles P, Sales-Dias J, Andrade CM, Mello-Vieira J, Mancio-Silva L, Simas JP, Staines HM, Prudêncio M. GLUT1-mediated glucose uptake plays a crucial role during Plasmodium hepatic infection. Cell Microbiol. 2017 Feb. PMID: 27404888 

2016

Macciocchi D, Lanini S, Vairo F, Zumla A, Figueiredo LT, Lauria FN, Strada G, Brouqui P, Puro V, Krishna S, Kremsner P, Scognamiglio P, Köhler C, Nicastri E, Di Caro A, Cieri RM, Ioannidis JP, Kobinger G, Burattini MN, Ippolito G. Short-term economic impact of the Zika virus outbreak.New Microbiol. 2016 Oct. PMID: 28004846 

 

Krishna S, Staines HM, Kremsner PG. Artemisinin Resistance and Blame Game. Clin Infect Dis. 2016 Oct. No abstract available. PMID:27461919 

 

Arch Toxicol. 2016 Aug 12 Hepatotoxicity by combination treatment of temozolomide, artesunate and Chinese herbs in a glioblastoma multiforme patient: case report review of the literature. PMID:27519711

 

Meireles P, Sales-Dias J, Andrade CM, Mello-Vieira J, Mancio-Silva L, Simas JP, Staines HM, Prudêncio M. GLUT1-mediated glucose uptake plays a crucial role during Plasmodium hepatic infection. Cell Microbiol. 2016 Jul 12. PMID:  27404888


Krishna S, Staines HM, Kremsner PG. Clin Infect Dis. 2016 Jul Artemisinin Resistance and the Blame Game. PMID:27461919 

 

Wu Y, Wu RW, Cheu KW, Williams ID, Krishna S, Slavic K, Gravett AM, Liu WM, Wong HN, Haynes RK. ChemMedChem. 2016 Jul Methylene Homologues of Artemisone: An Unexpected Structure-Activity Relationship and a Possible Implication for the Design of C10-Substituted Artemisinins. PMID: 27273875 

 

Karuppuchamy T, Behrens EH, González-Cabrera P, Sarkisyan G, Gima L, Boyer JD, Bamias G, Jedlicka P, Veny M, Clark D, Peach R, Scott F, Rosen H, Rivera-Nieves J, Mucosal Immunol. 2016 Apr 6. Sphingosine-1-phosphate receptor-1 (S1P1) is expressed by lymphocytes, dendritic cells, and endothelium and modulated during inflammatory bowel disease. PMID: 27049060 

 

Schmutzhard J, Lackner P, Helbok R, Hurth HV, Aregger FC, Muigg V, Kegele J, Bunk S, Oberhammer L, Fischer N, Pinggera L, Otieno A, Ogutu B, Agbenyega T, Ansong D, Adegnika AA, Issifou S, Zorowka P, Krishna S, Mordmüller B, Schmutzhard E, Kremsner P. BMC Med. 2016 Apr Erratum to: Severe malaria in children leads to a significant impairment of transitory otoacoustic emissions - a prospective multicenter cohort study. PMID: 27106862

Agnandji ST, Huttner A, Zinser ME, Njuguna P, Dahlke C, Fernandes JF, Yerly S, Dayer JA, Kraehling V, Kasonta R, Adegnika AA, Altfeld M, Auderset F, Bache EB, Biedenkopf N, Borregaard S, Brosnahan JS, Burrow R, Combescure C, Desmeules J, Eickmann M, Fehling SK, Finckh A, Goncalves AR, Grobusch MP, Hooper J, Jambrecina A, Kabwende AL, Kaya G, Kimani D, Lell B, Lemaître B, Lohse AW, Massinga-Loembe M, Matthey A, Mordmüller B, Nolting A, Ogwang C, Ramharter M, Schmidt-Chanasit J, Schmiedel S, Silvera P, Stahl FR, Staines HM, Strecker T, Stubbe HC, Tsofa B, Zaki S, Fast P, Moorthy V, Kaiser L, Krishna S, Becker S, Kieny MP, Bejon P, Kremsner PG, Addo MM, Siegrist CA. N Engl J Med. 2016 Apr. Phase 1 Trials of rVSV Ebola Vaccine in Africa and Europe. PMID:  25830326

 

Ippolito G, Lanini S, Brouqui P, Di Caro A, Vairo F, Fusco FM, Krishna S, Capobianchi MR, Kyobe-Bosa H, Puro V, Wölfel R, Avsic-Zupanc T, Ioannidis JP, Portella G, Kremsner P, Dar O, Bates M, Zumla A. Lancet Infect Dis. 2016 Apr Non-randomised Ebola trials--lessons for optimal outbreak research. PMID: 27036341 

 

Saeed ME, Krishna S, Greten HJ, Kremsner PG, Efferth T. Pharmacol Res. 2016 Aug. Antischistosomal activity of artemisinin derivatives in vivo and in patients. PMID: 26902577 

Slavic K, Krishna S, Lahree A, Bouyer G, Hanson KK, Vera I, Pittman JK, Staines HM, Mota MM.  Nat Commun. 2016 Jan. A vacuolar iron-transporter homologue acts as a detoxifier in Plasmodium. PMID:26786069 

 

Kremsner PG, Adegnika AA, Hounkpatin AB, Zinsou JF, Taylor TE, Chimalizeni Y, Liomba A, Kombila M, Bouyou-Akotet MK, Mawili Mboumba DP, Agbenyega T, Ansong D, Sylverken J, Ogutu BR, Otieno GA, Wangwe A, Bojang KA, Okomo U, Sanya-Isijola F, Newton CR, Njuguna P, Kazungu M, Kerb R, Geditz M, Schwab M, Velavan TP, Nguetse C, Köhler C, Issifou S, Bolte S, Engleitner T, Mordmüller B, Krishna S. PLoS Med. 2016 Jan. Intramuscular Artesunate for Severe Malaria in African Children: A Multicenter Randomized Controlled Trial. PMID:26757276

2015

Augustin Y, Krishna S, Kumar D, Pantziarka P. Ecancermedicalscience. 2015 Oct. The wisdom of crowds and the repurposing of artesunate as an anticancer drug. PMID:26557887 

 

Pulcini S, Staines HM, Lee AH, Shafik SH, Bouyer G, Moore CM, Daley DA, Hoke MJ, Altenhofen LM, Painter HJ, Mu J, Ferguson DJ, Llinás M, Martin RE, Fidock DA, Cooper RA, Krishna S. Sci Rep. 2015 Sep. Mutations in the Plasmodium falciparum chloroquine resistance transporter, PfCRT, enlarge the parasite's food vacuole and alter drug sensitivities. PMID:26420308

 

Ippolito G, Lanini S, Brouqui P, Di Caro A, Vairo F, Abdulla S, Fusco FM, Krishna S, Capobianchi MR, Kyobe-Bosa H, Lewis DJ, Puro V, Wolfel R, Avsic-Zupanc T, Dar O, Mwaba P, Bates M, Heymann D, Zumla A. Lancet Infect Dis. 2015 Jul. Ebola: missed opportunities for Europe-Africa research. PMID: 26231479

 

Schmutzhard J, Lackner P, Helbok R, Hurth HV, Aregger FC, Muigg V, Kegele J, Bunk S, Oberhammer L, Fischer N, Pinggera L, Otieno A, Ogutu B, Agbenyega T, Ansong D, Adegnika AA, Issifou S, Zorowka P, Krishna S, Mordmüller B, Schmutzhard E, Kremsner P. BMC Med. 2015 May. Severe malaria in children leads to a significant impairment of transitory otoacoustic emissions--a prospective multicenter cohort study. PMID:26021376

 

Lanini S, Zumla A, Ioannidis JP, Caro AD, Krishna S, Gostin L, Girardi E, Pletschette M, Strada G, Baritussio A, Portella G, Apolone G, Cavuto S, Satolli R, Kremsner P, Vairo F, Ippolito G. Lancet Infect Dis. 2015 Apr 13. Are adaptive randomised trials or non-randomised studies the best way to address the Ebola outbreak in west Africa? PMID: 25881871 

 

Agnandji ST1, Huttner A, Zinser ME, Njuguna P, Dahlke C, Fernandes JF, Yerly S, Dayer JA, Kraehling V, Kasonta R, Adegnika AA, Altfeld M, Auderset F, Bache EB, Biedenkopf N, Borregaard S, Brosnahan JS, Burrow R, Combescure C, Desmeules J, Eickmann M, Fehling SK, Finckh A, Goncalves AR, Grobusch MP, Hooper J, Jambrecina A, Kabwende AL, Kaya G, Kimani D, Lell B, Lemaître B, Lohse AW, Massinga-Loembe M, Matthey A, Mordmüller B, Nolting A, Ogwang C, Ramharter M, Schmidt-Chanasit J, Schmiedel S, Silvera P, Stahl FR, Staines HM, Strecker T, Stubbe HC, Tsofa B, Zaki S, Fast P, Moorthy V, Kaiser L, Krishna S, Becker S, Kieny MP, Bejon P, Kremsner PG, Addo MM, Siegrist CA. Phase 1 Trials of rVSV Ebola Vaccine in Africa and Europe - Preliminary Report. N Engl J Med. 2015 Apr 1. PMID: 25830326

 

Pinheiro MM, Ahmed MA, Millar SB, Sanderson T, Otto TD, Lu WC, Krishna S, Rayner JC, Cox-Singh J. Plasmodium knowlesi Genome Sequences from Clinical Isolates Reveal Extensive Genomic Dimorphism. PLoS One. 2015 Apr 1, PMID: 25830531 

 

Rolling T, Agbenyega T, Krishna S, Kremsner PG, Cramer JP. Delayed haemolysis after artesunate treatment of severe malaria - Review of the literature and perspective. Travel Med Infect Dis. 2015 Mar-Apr; PMID: 25812775 

 

The WorldWide Antimalarial Resistance Network (WWARN) AS-AQ Study Group. (2015). The Effect of Dosing Strategies on the Therapeutic Efficacy of Artesunate Amodiaquine for Uncomplicated Malaria: A Meta-Analysis of Individual Patient Data. BMC Medicine. PMID: 25888957  

 

This must be the year we beat Ebola in West Africa .Sanjeev Krishna receives funding from the World Health Organisation and the Wellcome Trust as part of a consortium to develop a vaccine against Ebola. Carwyn Hooper does not work for, consult to, own shares in or receive funding from any company or organisation that would benefit from this article, and has no relevant affiliations. Published by The Converstation 2 January, 2015 

2014

Sanjeev Krishna, Senthil Ganapathi, Irina Chis Ster, Mohamed E.M. Saeed, Matt Cowan, Caroline Finlayson, Hajnalka Kovacsevics, Herwig Jansen, Peter G. Kremsner, Thomas Efferth, Devinder Kumar. A Randomised, Double Blind, Placebo-Controlled Pilot Study of Oral Artesunate Therapy for Colorectal Cancer. EBioMedicine, EBIOM-00033; No of Pages 9, 2014 PMID: 26137537 

 

Zaloumis S, Tarning J, Krishna S, Price R, White NJ, DavisTME, McCaw J, Olliaro P, Maude R, Kremsner P, Dondorp A, Gomes M, Barnes K, and Simpson J. (2014). Population pharmacokinetics of intravenous artesunate: a pooled analysis of individual data from patients with severe malaria. Clinical Pharmacology and Therapeutics: Pharmacometrics and Systems Pharmacology. (in press). 

 

Ahmed AM, Pinheiro MM, Divis, PC, Sinner A, Zainudin R, Wong IT Lu CW, Singh-Khaira S, Millar SB, Lynch S, Willmann M, Singh B, Krishna S, Cox-Singh J. (2014). Disease progression in Plasmodium knowlesi is linked to variation in invasion gene family members. PLoS Neglected Diseases 8:e3086 PMID: 25121807 

 

To fight malaria, we now have genetic weapons that track and kill. Every year malaria kills more than 600,000, which is a little less than the population of Bhutan. There are some simple solutions to control the disease, but keeping the numbers of mosquitoes with malarial parasites down remains a challenge. Published by The Converstation 16th June 2014. 

 

Talman A, Prieto JH, Marques S, Ubaida-Mohien C, Lawniczak M, Wass MN< Xu T, Frank R, Ecker A, Stanway RS, Krishna S, Sternberg MJE, Christophides GK, Graham DR, Dinglasan RR, Yates III JR, Sinden RE. (2014). Proteomic analysis of the Plasmodium male gamete reveals the key role for glycolysis in flagellar motility. Malaria Journal PMID: 25124718 

 

Foster D, Cox-Singh J, Mohamad DS, Krishna S, Chin PP, Singh B. Evaluation of three rapid diagnostic tests  for the detection of human infections with Plasmodium knowles. Malar J. 2014 Feb 18;13(1):60. PMID: 24548805  

 

Rolling T, Agbenyega T, Issifou S, Adegnika AA, Sylverken J, Spahlinger D, Ansong D, Löhr SJ, Burchard GD, May J, Mordmüller B, Krishna S, Kremsner PG,Cramer JP. Delayed Hemolysis After Treatment With Parenteral Artesunate in African Children With Severe Malaria--A Double-center Prospective Study. J Infect Dis. 2014 Jan 29. PMID: 24376273  

 

Krishna S, Pulcini S, Moore CM, Teo BH, Staines HM. Trends Pharmacol Sci. 2014 Jan;35(1):4-11. Pumped up: reflections on PfATP6 as the target for artemisinins. PMID: 24268763 

2013

Krishna, S., & Kremsner, P. G. (2013). Artemisinin resistance needs to be defined rigorously to be understood: response to Dondorp and Ringwald.. Trends Parasitol. 2013 Aug;29(8):361-2. PMID23809865 

 

Ratzinger F1, Bruckschwaiger H, Wischenbart M, Parschalk B, Fernandez-Reyes D, Lagler H, Indra A, Graninger W, Winkler S, Krishna S, Ramharter M. (2012). Rapid Diagnostic Algorithms as a Screening Tool for Tuberculosis: An Assessor Blinded Cross-Sectional Study. PLoS One. 2012;7(11):e496586 pages. PMID23185397 

 

Tiberti N, Matovu E, Hainard A, Enyaru JC, Lejon V, Robin X, Turck N, Ngoyi DM, Krishna S, Bisser S, Courtioux B, Büscher P, Kristensson K, Ndung’u JM, Sanchez J-C. (2013). New Biomarkers for stage determination in Trypanosoma brucei rhodesiense sleeping sickness patients. Clinical and Translational Medicine PMID: 23369533 

 

Pulcini S, Staines HM, Pitman JK, Slavic K, Doerig C, Halbert J, Tewari R, Shah F, Avery MA, Haynes RK, Krishna S (2013). Expression in yeast links field polymorphisms in PfATP6 to in vitro artemisinin resistance and identifies new inhibitor classes. Journal of Infectious Diseases PMID: 23599312 

 

Newton PN, Stepniewska K, Dondorp A, Silamut K, Chierakul W, Krishna S, Davies TME, Suputtamongkol Y, Angus B, Pukrittayakamee S, Ruangveerayuth R, Hanson J, White NJ, Day NPJ. (2013). Prognostic indicators in adults hospitalized with falciparum malaria in Western Thailand. Malaria J PMID: 23829311 

 

Tjhin ET, Staines HM, van Schalkwyk DA, Krishna S, Saliba KJ. (2013). Studies with Plasmodium falciparum hexokinase reveal that PfHT limits the rate of glucose entry into glycolysis. FEBS Letters PMID: 23954294 Krishna S, Kremsner PG. (2013). Antidogmatic approaches to artemisinin resistance: reappraisal as treatment failure with artemisinin combination therapy. Trends in Parasitology PMID: 23623760

 

Controlling mosquito sex lives is one way to filght malaria. Controlling malaria is a war being waged on many fronts. Mosquito nets and coils repel mosquitoes from their human feast…Published by The Converstation 29th October 2013 

 

New malaria vaccine has its flaws, but it's better that nothing. The announcement that GlaxoSmithKline (GSK) aims to register a malaria vaccine came on the same day Peter Higgs and Francois Englert were awarded the Nobel prize in physics for predicting the existence…Published by The Converstation 9th October 2013 

 

Fatih FA, Staines HM, Siner A, Ahmed MA, Woon LC, Pasini EM, Kocken CH, Singh B, Cox-Singh J, Krishna S. (2013). Susceptibility of human Plasmodium knowlesi infections to antimalarials. Malaria Journal PMID: 24245918 

 

Krishna S, Pulcini S, Moore CM, Teo BH, Staines HM. (2013). Pumped up: reflections on PfATP6 as the target for artemisinins. Trends in Pharmacological Sciences PMID: 24268763 

Rolling T, Agbenyega T, Issifou S, Adegnika AA, Sylverken J, Spahlinger D, Ansong D, Löhr SJ, Burchard GD, May J, Mordmüller B, Krishna S, Kremsner PG, Cramer JP. (2013). Delayed hemolysis after treatment with parenteral artesunate in African children with severe malaria--a double-center prospective study.Journal of Infectious Diseases PMID: 24376273

2012

Fatih FA, Siner A, Ahmed A, Woon LC, Craig A, Singh B, Krishna S, Cox-Singh J. (2012). Cytoadherence and virulence – the case of Plasmodium knowlesi malaria. Malaria Journal 11:33. PMID: 22305466 

 

Craig A, Grau GE, Kazura JW, Milner D, Barnwell JW, Turner G and Langhorne J on behalf of 22 participants (listed in Table 1) of the Hinxton Retreat meeting on “Animal Models for Research on Severe Malaria”. (2012). PLoS Pathogens 8: e1002401. PMID: 22319438 

 

Ratzinger F, Bruckschwaiger H, Wischenbart M, Parschalk B, Fernandez-Reyes D, Indra A, Graninger W, Winkler S, Krishna S, Ramharter M. (2012). Rapid diagnostic algorithms as a screening tool for tuberculosis: an assessor blinded cross-sectional study. PLoS One 2012;7(11):e49658. Epub 2012 Nov 21 PMID: 23185397 

 

Pillai D, Lau R, Khairnar K, Lepore R, Via A, Staines HM, Krishna S. (2012). Artemether resistance in vitro is linked to mutations in PfATP6 that also interact with mutations in PfMDR1 in travellers returning with Plasmodium falciparum. Malaria Journal Apr 27;11:131. PMID: 22540925 

 

Guttery DS, Pittman JK, Frénal K, Poulin B, McFarlane LR, Slavic K, Wheatley S, Soldati-Favre D, Krishna S, Tewari R, Staines HM. (2013). The Plasmodium berghei Ca2+/H+ exchanger, PbCAX, is essential for environmental tolerance to Ca2+ during sexual development. PLoS Pathogen PMID: 23468629 

 

Tiberti N, Hainard A, Lejon V, Courtioux B, Matovu E, Enyaru JC, Robin X, Turck N, Kristensson K, Ngoyi DM, Vatunga GM, Krishna S, Büscher P,  Bisser S, Ndung’u JM, Sanchez J-C. (2012). Cerebrospinal fluid neopterin as a marker of the meningo-encephalitic stage of Trypanosoma brucei gambiense sleeping sickness PLoS One 2012;7(7):e40909. Epub 2012 Jul 18. PMID: 22815865

 

Willmann M, Ahmed A, Siner A, Tien WI, Voon LC, Singh B, Krishna S, Cox-Singh J. (2012). Laboratory markers of disease severity in Plasmodium knowlesi infection Malaria J. PMID: 23110615

 

Krishna, S. (2012). Adjunctive management of malaria.. Curr Opin Infect Dis, 25(5), 484-488. PMID: 22907277

 

Pillai D, Lau R, Khairnar K, Lepore R, Via A, Staines HM, Krishna S. (2012). Artemether resistance in vitro is linked to mutations in PfATP6 that also interact with mutations in PfMDR1 in travellers returning with Plasmodium falciparum. Malaria Journal Apr 27;11:131. PMID: 22540925

 

Kremsner PG, Taylor T, Issifou S, Kombila M, Chimalizeni Y, Kawaza K, Akotet KB, Duscha M, Mordmüller B, Kösters K, Humberg A, Miller RS, Weina P, Duparc S, Möhrle J, Kun JFJ, Planche T, Teja-Isavadharm P, Simpson JA, Köhler C, Krishna S. (2012). A simplified intravenous artesunate regimen for severe malaria. Journal of Infectious Diseases 205: 312-319. PMID: 22180622

 

Krishna, S., & Staines, H. M. (2012). Non-Antifolate Antibiotics: Clindamycin,Doxycycline, Azithromycin and Fosmidomycin.

 

H. M. Staines, & S. Krishna (Eds.), Treatment and Prevention of Malaria: Antimalarial Drug Chemistry, Action and Use (pp. 141-156). Basel: Springer. 315 pages (16 chapters) ISBN 978-3-0346-0479-6.

2011

Pooley S, Fatih F, Krishna S, Gerisch M, Haynes RK, Wong H-N, Staines HM. (2011). Artemisone uptake in Plasmodium falciparum-infected erythrocytes. Antimicrobial Agents and Chemotherapy 55: 550-6 PMID: 21135191 

 

Lubell Y, Staedke S, Greenwood BM, Kamya M, Newton P, Molyneux M, Reyburn H, Snow R, D’Allesandro U, English M, Day N, Kremsner PG, Dondorp A, Mbacham W, Dorsey G, Owusu-Agyei S, Maitland K, Krishna S, Newton C, Pasvol G, von Seidlein L, Taylor T, White NJ, Binka F, Mills A, Whitty CJM. (2011). Likely health outcomes for untreated febrile illness in the tropics in decision and economic models; a Delphi survey PLoS One 6: e17439.PMID: 21390277 

 

Slavic K, Talman AM, Delves MJ, Prudêncio M, Straschil U, Derbyshire ET, Xu Z, Sinden RE, Mota MM, Morin C, Tewari R, Krishna S, Staines HM. (2011). Use of a selective inhibitor to define the physiological importance of the plasmodial hexose transporter in the different stages of the parasite’s life cycle. Antimicrobial Agents and Chemotherapy 55: 2824-2830. PMID: 21402842 

 

Slavic K, Derbyshire E, Staines HM, Krishna S. (2011). Hexose transporters as novel targets for antiparasitic drug discovery. Malaria Journal 10: 165.PMID: 21676209 

 

Salcedo-Sora JE, Ochung E, Nzila A, Beveridge S, Biagini GA, Stocks PA, Johnson D, O’Neill PM, Krishna S, Ward SA, Bray PG. (2011). The molecular basis of folate salvage in Plasmodium falciparum: characterisation of two folate transporters. Journal of Biological Chemistry 286: 44659 – 44668.PMID: 21998306 

 

Cox-Singh J. Singh B, Daneshvar C, Planche T, Parker-Williams J, Krishna S. (2011). Antiinflammatory markers predominate in acute human Plasmodium knowlesi malaria. PLoS One 6:e20541. PMID: 21687657 

 

Kremsner PG, Taylor T, Issifou S, Kombila M, Chimalizeni Y, Kawaza K, Akotet KB, Duscha M, Mordmüller B, Kösters K, Humberg A, Miller RS, Weina P, Duparc S, Möhrle J, Kun JFJ, Planche T, Teja-Isavadharm P, Simpson JA, Köhler C, Krishna S. (2011). A simplified intravenous artesunate regimen for severe malaria. Journal of Infectious Diseases 205: 312-319. PMID: 22180622

2010

Cox-Singh J, Hiu J, Lucas S, Divis PC, Zulkarnaen AN,  Wang PC, Adem P, Zaki SR, Singh B, Krishna S. (2010). Severe malaria: A case of fatal Plasmodium knowlesi infection with post mortem findings – a case report. Malaria Journal 9: 10. PMID: 20064229 

 

Staines H, Derbyshire ET, Slavic K, Tattersall A, Vial V, Krishna S. (2010).  Exploiting the therapeutic potential of transporters of Plasmodium falciparum. Trends in Parasitology 26: 284-96. PMID: 20392668

 

K, Straschil U, Reininger L, Doerig C, Morin C, Tewari R, Krishna S. (2010). Life cycle studies of the hexose transporter of Plasmodium species. Molecular Microbiology 75: 1402-1413. PMID: 20132450

 

A, Pope C, Bray S, Riley P, Breathnach A, Krishna S, Planche T. (2010). Prospective assessment of two-stage testing for Clostridium difficile. Journal of Hospital Infection 76: 18-22. PMID: 20638749

 

 Krishna S, Pulcini S, Fatih F, Staines H. (2010).  Artemisinins and the biological basis of the PfATP6/SERCA hypothesis. Trends in Parasitology 26: 517-523. PMID: 20638904 

 

Cowan M, Rahman T, Krishna S. (2010). Proteomic approaches in the search for biomarkers of liver fibrosis. Trends in Molecular Medicine 16: 171-183. PMID: 20304704 

 

Gravett AM, Liu WM, Krishna S, Chan W-C, Haynes RK, Wilson N, Dalgleish AG. (2010). In vitro study of the anti-cancer effects of artemisone alone or in combination with other chemotherapeutic agents. Cancer Chemotherapy and Pharmacology 67: 569-577. PMID: 20490800

 

Cardi D, Pozza A, Arnou B, Marchal E, Clausen JD, Andersen JP, Krishna S, Møller JV, le Maire M, Jaxel C. (2010). Purified E255L mutant Serca1a and purified PfATP6 are sensitive to SERCA-type inhibitors but insensitive to artemisinins. Journal of Biological Chemistry 285: 26406-16. PMID: 20530490

 

Valderramos SG, Scanfield D, Uhlemann A-C, Fidock DA, Krishna S. (2010). Investigations into the role of the Plasmodium falciparum SERCA (PfATP6) L263E mutation in artemisinin action and resistance. Antimicrobial Agents and Chemotherapy 54: 3842 – 52. PMID: 20566762

 

Planche T,Macallan DC, Sobande T, Borrmann S, Kun JF, Krishna S, Kremsner PG. (2010). Nitric oxide generation in children with malaria and the NOS2G-954C promotor polymorphism. American Journal of Physiology, Regulatory, Integrative and Compatative Physiology 299: R1248-53. PMID: 20811009
2009

Kremsner PG, Valim C, Missinou M, Olola C, Krishna S, Issifou S, Kombila M, Bwanaisa L, Mithwanin S, Newton C, Agbenyega T, Pinder M, Bojang K, Wypij D, Taylor T. (2009). The prognostic value of circulating pigmented cells in severe malaria in African children. Journal of Infectious Diseases 199 142-150. PMID: 19086817 

 

Gomes MF, Faiz MA, Gyapong J, Warasme M, Agbenyega T, Babiker A, Baiden F, Bin Yunus E, Binka F, Ckerk C, Folb P, Hassan R, Hossein Md A,         Kimbute O, Kitua A, Krishna S, Makasi C, Mensah N, Mrango Z, Olliaro P, Peto R, Peto TJ, Rahman MR, Ribiero I, Samad R, White NJ for the Study 13 research group. (2009). Pre-referral rectal artesunate to prevent death and disability in severe malaria: placebo-controlled trial. The Lancet 373: 557-566.  PMID: 19059639 

 

Macallan DC, Abaye DA, Dottin S, Onanga M, Kombila M, Dzeing-Ella A, Kremsner PG, Krishna S, Planche T. (2009). Blood volume and red cell mass in children with moderate and severe malaria measured by chromium-53 dilution and gas chromatography/mass spectrometric analysis. Rapid Communications in Mass Spectrometry 23: 2467-75. PMID: 19603467 

 

Prudêncio M, Derbyshire ET, Marques CA, Krishna S, Mota MM, Staines HM. (2009). Plasmodium berghei infection induces volume-regulated anion channel-like activity in human hepatoma cells. Cellular Microbiology 11: 1492-501. PMID: 19496788 

 

Slavic K, Derbyshire E, Naftalin RJ, Krishna S, Staines HM. (2009). Comparison of effects of green tea catechins on apicomplexan hexose transporters and mammalian orthologues. Molecular and Biochemical Parasitology 168: 113-116. PMID: 19577593 

 

Doerig C, Baker D, Billker O, Blackman MJ, Chitnis C, Dhar K, Heussler V, Holder AA, Kocken C, Krishna S, Langsley G, Lasonder E, Menard R, Meissner M, Pradel G, Ranford-Cartwright L, Sharma A, Sharma P, Tardieux T, Tatu U, Alano P. (2009). Signalling in malaria parasites. The MALSIG consortium. Parasite 16: 169-182. PMID: 19839262 

2008

Toovey S, Bustamante LY, Uhlemann A-C, East M, Krishna S. (2008). Effect of artemisinins and amino alcohol partner antimalarials on mammalian sarcoendoplasmic reticulum adenosine triphosphatase (SERCA) activity. Basic and Clinical Pharmacology and Toxicology 2008 Sep;103(3):209-13. Epub 2008 Jul 18. PMID: 18684232 

 

Derbyshire E, Franssen FJ, de Vries E, Morin C, Woodrow CJ, Krishna S, Staines HM. (2008).  Identification, expression and characterisation of a Babesia bovis hexose transporter. Molecular and Biochemical Parasitology Oct;161(2):124-9. Epub 2008 Jun 27. PMID: 18638508 

 

Rojas-Galeano S, Hseih E, Agranoff D, Krishna S, Fernandez-Reyes D. (2008). Estimation of relevant variables on high-dimensional biological patterns using iterated weighted kernal functions. PLoS One 26: 3 PMID: 18509521 

 

Planche T, Aghaizu A, Holliman R, Polienicki J, Breathack A, Krishna S. (2008). Diagnosis of Clostridium difficile by use of toxin detection kits: a systematic review. Lancet Infectious Diseases 8: 777-84. PMID: 18977696 

 

Krishna S, Bustamante L, Haynes RK, Staines HM. (2008). Artemisinins: their growing importance in medicine. Trends in Pharmacological Sciences 29: 520-7.PMID: 18752857

 

 

 

 

 

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