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Supervisory Team
Project details
This PhD project will investigate the modulatory role of mechanosensitive channels in regulating and maintaining neuronal excitability and brain network activity in physiological and pathological conditions. Mechanosensitive transmembrane ion channels Piezo are essential cellular mechanotransducers regulating cell adaptation to the microenvironment. In the central nervous system, mechanotransduction-coupled cascades involving Piezo channels remain largely unexplored, especially in the context of channel expression and functional activity in neurons and astrocytes. Astrocytes play a critical role in maintaining brain function by regulating glutamate-induced excitotoxicity, acidification, glucose deprivation, and other fundamental processes in the brain. This research will focus on deciphering the mechanosensation mediated by Piezo1 channels in neurons and astrocytes in organised brain tissue. We aim to explore how Piezo1 channels influence neurotransmission and network activity by utilising novel optical tools and a combination of advanced neuroscience techniques in brain tissue. It is envisaged that the study will combine electrophysiology, including extracellular and patch-clamp recordings, with live-cell imaging to assess the performance of principal neurons and astrocytes using novel optical sensors and genetic manipulations. This research will ultimately identify the role of Piezo1 channels as potential targets for modulating neuronal activity in both physiological and pathological conditions.
Skills acquisition
We expect that a person will help to:
- develop a broad range of research within the specified topic
- direct and perform experimental work using electrophysiological and live-cell fluorescent imaging approaches
- implement novel optical tools for real-time monitoring of neuronal activity and neurotransmission
- perform sophisticated data analysis
- contribute to the preparation of research materials for publication in peer reviewed journals
- support research in the laboratory
- present work.
Prior educational requirements
Applicants are expected to hold a first degree in neuroscience, clinical neuroscience, or physiology, have a good understanding of cellular neuroscience and basic knowledge of biophysics and/or cellular biology. Other relevant skills will be taught during the project.
While not required, having a post-graduate degree (e.g., Masters, MPhil) would be an advantage, particularly in a mixed methods. Prior experience in electrophysiology and/or fluorescent imaging is highly recommended.
Read the full eligibility criteria.
Funding
This studentship is open to all applicants and provides funding for 3 years full-time and includes home tuition fees plus a tax-free stipend in line with UKRI rates. Overseas students would be expected to demonstrate that they can pay the difference between the home rate and the overseas rate.
How to apply
Prospective applicants are welcome to contact Dr Olga Kopach to discuss the project.
Please send the completed application form (Word) to stgeorgesphd@sgul.ac.uk by no later than 5pm on 30 May 2025.
An equal opportunities form (Word) should also be submitted as a separate document. References will be requested should you be successful in being offered the studentship.
Applications will undergo shortlisting and successful applicants will then be invited to interview week beginning 15 June 2025.
The successful candidate will be given a verbal offer and once it has been accepted, will be sent a formal offer letter and a registration pack with joining information.
Unsuccessful candidates will be contacted with their outcomes at the earliest opportunity and will be able to request feedback if required.