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Dr Ariel Poliandri

Head of Research Space and Safety

I work on the implementation of St George’s research operations strategy with a particular emphasis on research space management and all aspects of health and safety in laboratories. I am also St George’s Biological Safety Officer of Genetic Modification, overseeing all work with Genetically Modified Organisms in the University. Additionally, I am the manager of St George’s containment levels 3 facilities.

Oduwole OO, Poliandri A, Okolo A, Rawson P, Doroszko M, Chrusciel M, Rahman NA, Serrano de Almeida G, Bevan CL, Koechling W, Huhtaniemi IT. Follicle-stimulating hormone promotes growth of human prostate cancer cell line-derived tumor xenografts. FASEB J. 2021 Apr e21464..

Oduwole OO, Peltoketo H, Poliandri A, Vengadabady L, Chrusciel M, Doroszko M, Samanta L, Owen L, Keevil B, Rahman NA, Huhtaniemi IT. Constitutively active follicle-stimulating hormone receptor enables androgen-independent spermatogenesis. J Clin Invest. 2018 Mar 26.

Miller DC, Harmer SC, Poliandri A, Nobles M, Edwards EC, Ware JS, Sharp TV, McKay TR, Dunkel L, Lambiase PD, Tinker A.Ajmaline blocks INa and IKr without eliciting differences between Brugada syndrome patient and control human pluripotent stem cell-derived cardiac clusters. Stem Cell Res. 2017 25:233-244.

Howard SR, Guasti L, Poliandri A, David A, Cabrera CP, Barnes MR, Wehkalampi K, O'Rahilly S, Aiken CE, Coll AP, Ma M, Rimmington D, Yeo GSH, Dunkel L. Contributions of Function-Altering Variants in Genes Implicated in Pubertal Timing and Body Mass for Self-Limited Delayed Puberty. J Clin Endocrinol Metab. 2018 103:649-659.

Poliandri A, Miller D, Howard S, Nobles M, Ruiz-Babot G, Harmer S, Tinker A, McKay T, Guasti L, Dunkel L. Generation of kisspeptin-responsive GnRH neurons from human pluripotent stem cells. Mol Cell Endocrinol. 2017 447:12-22.

Ishida H, Saba R, Kokkinopoulos I, Hashimoto M, Yamaguchi O, Nowotschin S, Shiraishi M, Ruchaya P, Miller D, Harmer S, Poliandri A, Kogaki S, Sakata Y, Dunkel L, Tinker A, Hadjantonakis AK, Sawa Y, Sasaki H, Ozono K, Suzuki K, Yashiro K. GFRA2 Identifies Cardiac Progenitors and Mediates Cardiomyocyte Differentiation in a RET-Independent Signaling Pathway. Cell Rep. 2016 16:1026-1038.

Rosell M, Nevedomskaya E, Stelloo S, Nautiyal J, Poliandri A, Steel JH, Wessels LF, Carroll JS, Parker MG, Zwart W. Complex formation and function of estrogen receptor α in transcription requires RIP140. Cancer Res. 2014 74:5469-5479

Nautiyal J, Steel J, Rosell Mane M, Oduwole O, Poliandri A, Alexi X, Poutanen M, Zwart W, Stingl J, Parker M. The transcriptional co-factor RIP140 regulates mammary gland development by promoting the generation of key mitogenic signals. Development. 2013 140:1079-1089

Krutskikh A, Poliandri A, Cabrera-Sharp V, Dacheux JL, Poutanen M, Huhtaniemi I. Epididymal protein Rnase10 is required for post-testicular sperm maturation and male fertility. FASEB J. 2012 Jun 29.

(*Selected publication) Poliandri AH, Gamsby JJ, Christian M, Spinella MJ, Loros JJ, Dunlap JC, Parker MG. Modulation of clock gene expression by the transcriptional coregulator receptor interacting protein 140 (RIP140). J Biol Rhythms. 2011. 26:187-99.

Jiménez-Ortega V, Cardinali DP, Poliandri AH, Cano P, Toso CF, Esquifino AI. 24-Hour rhythm in gene expression of nitric oxide synthase and heme-peroxidase in anterior pituitary of ethanol-fed rats. Neurosci Lett. 2007 425:69-72.

Cano P, Poliandri AH, Jimenez V, Cardinali DP, Esquifino AI. Cadmium-induced changes in Per 1 and Per 2 gene expression in rat hypothalamus and anterior pituitary: Effect of melatonin. Toxicol Lett. 2007 172:131-6.

Quinteros FA, Poliandri AH, Machiavelli LI, Cabilla JP, Duvilanski BH. In vivo and in vitro effects of chromium VI on anterior pituitary hormone release and cell viability. Toxicol Appl Pharmacol. 2007 218:79-87.

Machiavelli LI, Poliandri AH, Quinteros FA, Cabilla JP, Duvilanski BH. Reactive oxygen species are key mediators of the nitric oxide apoptotic pathway in anterior pituitary cells. Nitric Oxide. 2007 16:237-246.

Poliandri AH, Esquifino AI, Cano P, Jiménez V, Lafuente A, Cardinali DP, Duvilanski1 BH, In vivo protective effect of melatonin on cadmium-induced changes in redox balance and gene expression in rat hypothalamus and anterior pituitary. J. Pineal Res. 2006 41:238-246.

Cabilla JP, Diaz MD, Machiavelli LI, Poliandri AH, Quinteros FA, Lasaga M, Duvilanski BH. 17{beta}-estradiol modifies nitric oxide sensitive-guanylyl cyclase expression and down-regulates its activity in rat anterior pituitary gland. Endocrinology. 2006 147:4311-4318.

Poliandri AH, Machiavelli LI, Quinteros AF, Cabilla JP, Duvilanski BH. Nitric oxide protects the mitochondria of anterior pituitary cells and prevents cadmium-induced cell death by reducing oxidative stress. Free Radic. Biol. Med. 2006 40:679-688.

Poliandri AH, Velardez MO, Cabilla JP, Bodo CCA, Machiavelli LI, Quinteros AF, Duvilanski BH. Nitric oxide protects anterior pituitary cells from cadmium-induced apoptosis. Free Radic. Biol. Med. 2004 37:1463-1471.

Velardez MO, Poliandri, AH, Cabilla JP, Bodo CC, Machiavelli LI, Duvilanski, BH. Long-term treatment of anterior pituitary cells with nitric oxide induces programmed cell death. Endocrinology. 2004 145:2064-2070. Epub 2003 Dec 30.

Poliandri AH, Cabilla JP, Velardez MO, Bodo CC, Duvilanski BH. Cadmium induces apoptosis in anterior pituitary cells that can be reversed by treatment with antioxidants. Toxicol Appl Pharmacol. 2003 190:17-24.

Velardez MO, Benitez(Poliandri) AH, Cabilla JP, Bodo CCA, Duvilanski BD. Nitric oxide decreases phosphoinositide production in anterior pituitary cells. Eur J Endocrinol. 2003 148(1):89-97.

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