Head of Section, Professor Pia Ostergaard.
The aim of the Genomics Research Section is to understand the molecular genetics and developmental aetiology of a range of single gene disorders, syndromes and complex traits. Current areas of research lie within the analysis and interpretation of DNA variants in human disease, focusing on translational bench-to-bedside approaches. As such, principal investigators within the section work closely with associate members from across the University and St George’s University Hospitals NHS Foundation Trust.
We study the impact of genomic variation on disease susceptibility, using multiple types of 'omics' data, including genomics, transcriptomics and proteomics to learn more about disease mechanisms. The University and the Trust are actively involved in the 100,000 Genomes Project, and the academic and clinical staff are members of the Genomics England Research Network Communities. These projects have the potential to transform the future of healthcare by improving the prediction and prevention of disease, enabling new and more accurate diagnostic tests and allowing the personalisation of drugs and treatments to specific gene variants.
We explore the function of disease-associated genes using cutting edge technologies and biological models. Using state-of-the-art molecular biology, biophysics, fluorescence and imaging approaches, we seek to understand the molecular and cellular mechanisms of health and disease. We also work closely with the Zebrafish Unit to examine developmental models of heart disease, eye disorders, ciliopathies, among others. Our research also goes hand-in-hand with undergraduate and postgraduate teaching at City St George’s.