Dr Veronica Carroll was appointed to Lecturer in Vascular Biology in 2013. Her research is directed towards understanding mTOR regulation and its role in vascular disease.
She has had previous research positions at the Institute of Cancer Research, the Weatherall Institute of Molecular Medicine, Oxford University and Imperial College London, working on the molecular mechanisms and therapeutic targeting of the hypoxia inducible factor pathway and angiogenesis.
Dr Carroll has a BSc (Hons) in Biochemistry. She received her PhD in Cell and Molecular Biology from the Department of Vascular Biology and Thrombosis Research at Vienna University.
Dr Carroll is the recipient of Young Investigator Awards from the British Association for Cancer Research and the American Association for Cancer Research. Her work on novel regulators of angiogenesis has been patented and funded by Isis Innovation, which is run by Oxford University. She frequently acts as an expert reviewer for numerous scientific journals.
Dr Carroll lectures to undergraduate students on the Medicine MBBS, BSc Biomedical Sciences and BSc Healthcare Sciences degree courses at St George’s. She contributes to tutorials, acts as supervisor for special study projects and facilitates case-based learning. She supervises laboratory-based research projects.
Dr Carroll also delivers postgraduate lectures to Biomedical Sciences MRes students on the Cardiovascular and Cancer modules. She is supervisor for research projects on this programme.
She is a module organiser on the Biomedical Science BSc for the following modules: 'Therapeutics and Investigation 2' (year 2); 'Biomedical Skills and Technologies 4' (year 2); 'Human Cardiovascular and Respiratory Pharmacology' (year 3). On the Healthcare Sciences degree she organises the module 'Pathophysiology of Common Cardiovascular and Respiratory Conditions' (year 2).
Dr Carroll is also a personal tutor.
- J Selvarajah, A Moumen and VA Carroll. Role of mTOR-Chk1 in enhancing DNA-damaging therapy. 2015 Cell Cycle 14:1989-1990
- J Selvarajah, A Elia, VA Carroll and A Moumen. DNA damage-induced S and G2/M cell cycle arrest requires mTORC2-dependent regulation of Chk1. 2015 Oncotarget 6:427-440
- J Selvarajah, K Nathawat, A Moumen, M Ashcroft and VA Carroll. Chemotherapy-mediated p53-dependent DNA damage response in clear cell renal cell carcinoma: role of the mTORC1/2 and hypoxia-inducible factor pathways. 2013 Cell Death Dis 4:e865
- Carroll VA and Ashcroft M. Role of hypoxia-inducible factor (HIF)-1a versus HIF-2a in the regulation of HIF target genes in response to hypoxia, insulin-like growth factor-1, or loss of von Hippel-Lindau function: Implications for targeting the HIF pathway. Cancer Res 2006; 66:6264-6270
- Collingridge DR, Carroll VA, Glaser M, EO Aboagye, S Osman, OC Hutchinson, H Barthel, SK Luthra, F Brady, R Bicknell, P Price, AL Harris. [124I]Iodinated-VG76e: a novel tracer for imaging vascular endothelial growth factor in vivo using positron emission tomography. Cancer Res 2002; 62:5212-5219.
- HM Fraser, SE Dickson, SF Lunn, C Wulff, KD Morris, VA Carroll and R Bicknell. Suppression of luteal angiogenesis and pregnancy in the primate after neutralization of vascular endothelial growth factor. Endocrinology 2000;141:995-1000.
Dr Debasish Banerjee (Renal and Transplantation Unit, St George’s Hospital)
Dr Tarek Antonios (St George's, University of London)
Dr Carroll has a longstanding interest in the development and more effective use of virtual learning environments to enhance the student experience. Current projects she is working on include the development of interactive teaching tools for distance learning.
Dr Carroll has a teaching development award from the Open University for research-led teaching. She holds a postgraduate certificate in Academic Practice and is a Fellow of The Higher Education Academy.
Dr Carroll is affiliated to the Vascular Biology Research Centre, Institute of Cardiovascular and Cell Sciences at St George's. Her research interests include hypoxia, mTOR signalling, DNA damage response, endothelial cell dysfunction and angiogenesis.
The lab is primarily focused on understanding the key signalling mechanisms induced by cellular stress (hypoxia, DNA damage, metabolic) as a basis for gaining a better understanding of chronic disease (cancer, cardiovascular and renal diseases). She has a particular interest in resistance mechanisms induced by anti-angiogenics and chemotherapeutics, and in the identification of resistance-induced targets that can be exploited therapeutically.
Current projects Dr Carroll is working on include understanding endothelial cell dysfunction in hypertension, investigating CVD risk factors in chronic kidney disease, particularly the role of the mTOR-HIF-p53 axis, and an AstraZeneca Open Innovation research project on dual targeting of DNA-damage and hypoxia-induced resistance pathways in breast cancer with mTORC1/2 inhibitors.