Research
Dr Yalda Jamshidi is a geneticist who focuses on cardiovascular disease and factors that contribute to its development.
Dr Jamshidi leads the Genome Medicine Research Lab. She is particularly interested in a collection of conditions (both inherited and acquired) that cause abnormalities in the rhythm of the heart muscle, and cardiac hypertrophy (when the heart muscle thickens).
She investigates the role genetic factors play in the development of these and other cardiovascular conditions. Her goal is to contribute to the development of new diagnostic tests and therapies that target genes and specific biological mechanisms involved in abnormal rhythm generation in the heart, allowing prevention and better treatment.
Biography
Before joining St George's, Dr Jamshidi worked as a postdoctoral fellow at King's College London, supervised by Dr Sandra O'Dell in the School of Medicine's Diabetes and Nutritional Sciences Division. Her work there focused on the molecular genetics of obesity. She also worked at the Institute of Child Health (supervised by Professor David Latchman, Professor of genetics). In this latter role, she investigated molecular mechanisms involved in cardiac hypertrophy.
Dr Jamshidi's first degree is a BSc (Hons) in Human Genetics, gained from University College London (UCL). Before completing her PhD at UCL in 2002, she was a visiting student at the Pasteur Institute in France, working in Professor Bart Staels's group, focusing on cardiovascular and metabolic diseases.
Her PhD – the role of PPAR-a in coronary heart disease and cardiac hypertrophy – was supervised by Dr Dave Flavell and Professor Steve Humphries in the Centre for Cardiovascular Genetics at UCL.
Publications
Selected Recent publications
2017
Osborn DP, Pond HL, Mazaheri N, Dejardin J, Munn CJ, Mushref K, Cauley ES, Moroni I, Pasanisi MB, Sellars EA, Hill RS, Partlow JN, Willaert RK, Bharj J, Malamiri RA, Galehdari H, Shariati G, Maroofian R, Mora M, Swan LE, Voit T, Conti FJ, Jamshidi Y*, Manzini MC*.Mutations in INPP5K Cause a Form of Congenital Muscular Dystrophy Overlapping Marinesco-Sjögren Syndrome and Dystroglycanopathy. Am J Hum Genet. 2017 Mar 2;100(3):537-545. *These authors contributed equally.
2016
Muggenthaler M, Petropoulou E, Omer S, Simpson MA, Sahak H, Rice A, Raju H, Conti FJ, Bridges LR, Anderson LJ, Sharma S, Behr ER, Jamshidi Y. Whole exome sequence analysis reveals a homozygous mutation in PNPLA2 as the cause of severe dilated cardiomyopathy secondary to neutral lipid storage disease. Int J Cardiol. 2016 May 1;210:41-4.
van der Harst P, van Setten J, Verweij N, Vogler G, Franke L, Maurano MT, Wang X, .... Newton-Cheh C*, Hicks AA*, Chambers JC*, Jamshidi Y*, Visel A*, Christoffels VM*, Isaacs A*, Samani NJ*, de Bakker PI*. 52 Genetic Loci Influencing Myocardial Mass. J Am Coll Cardiol. 2016 Sep 27;68(13):1435-48. *These authors contributed equally.
Carr G, Barrese V, Stott JB, Povstyan OV, Jepps TA, Figueiredo HB, Zheng D, Jamshidi Y, Greenwood IA. MicroRNA-153 targeting of KCNQ4 contributes to vascular dysfunction in hypertension. Cardiovasc Res. 2016 Jul 7. pii: cvw177.
Prins BP, Abbasi A, Wong A, Vaez A, Nolte I, .... Wijmenga C, Munroe PB, Perry JR, Pouget JG, Jamshidi Y, Snieder H, Alizadeh BZ. Investigating the Causal Relationship of C-Reactive Protein with 32 Complex Somatic and Psychiatric Outcomes: A Large-Scale Cross-Consortium Mendelian Randomization Study. PLoS Med. 2016 Jun 21;13(6):e1001976.
2015
UK10K Consortium. The UK10K project identifies rare variants in health and disease. Nature. 2015 Oct 1;526(7571):82-90.
Behr ER, Savio-Galimberti E, Barc J, Holst AG, Petropoulou E, Prins BP, Jabbari J, Torchio M, Berthet M, Mizusawa Y, Yang T, Nannenberg EA, Dagradi F, Weeke P, Bastiaenan R, Ackerman MJ, Haunso S, Leenhardt A, Kääb S, Probst V, Redon R, Sharma S, Wilde A, Tfelt-Hansen J, Schwartz P, Roden DM, Bezzina CR, Olesen M, Darbar D, Guicheney P, Crotti L; UK10K Consortium, Jamshidi Y. Role of common and rare variants in SCN10A: results from the Brugada syndrome QRS locus gene discovery collaborative study. Cardiovasc Res. 2015 Jun 1;106(3):520-9.
2014
Arking DE et al. Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization. Nat Genet. 2014 Aug;46(8):826-36.
Magnani JW, Brody JA, Prins BP, Arking DE, Lin H, Yin X, Liu CT, Morrison AC, Zhang F, Spector TD, Alonso A, Bis JC, Heckbert SR, Lumley T, Sitlani CM, Cupples LA, Lubitz SA, Soliman EZ, Pulit SL, Newton-Cheh C, O'Donnell CJ, Ellinor PT, Benjamin EJ, Muzny DM, Gibbs RA, Santibanez J, Taylor HA, Rotter JI, Lange LA, Psaty BM, Jackson R, Rich SS, Boerwinkle E, Jamshidi Y, Sotoodehnia N; CHARGE Consortium; NHLBI Exome Sequencing Project (ESP); UK10K. Sequencing of SCN5A identifies rare and common variants associated with cardiac conduction: Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium. Circ Cardiovasc Genet. 2014 Jun;7(3):365-73.
Petropoulou E, Jamshidi Y, Behr ER. The genetics of pro-arrhythmic adverse drug reactions. Br J Clin Pharmacol. 2014 Apr;77(4):618-25.
2013
den Hoed M, Eijgelsheim M et al. Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders. Nat Genet. 2013, Jun; 45(6): 621-31.
Behr ER, Ritchie MD, Tanaka T, Kääb S, Crawford DC, Nicoletti P, Floratos A, Sinner MF, Kannankeril PJ, Wilde AA, Bezzina CR, Schulze-Bahr E, Zumhagen S, Guicheney P, Bishopric NH, Marshall V, Shakir S, Dalageorgou C, Bevan S, Jamshidi Y, Bastiaenen R, Myerburg RJ, Schott JJ, Camm AJ, Steinbeck G, Norris K, Altman RB, Tatonetti NP, Jeffery S, Kubo M, Nakamura Y, Shen Y, George AL Jr, Roden DM. Genome wide analysis of drug-induced torsades de pointes: lack of common variants with large effect sizes. PLoS One. 2013 Nov 6; 8(11):e78511.
2012
Jamshidi Y, Nolte IM, Dalageorgou C, Zheng D, Johnson T, Bastiaenen R, Ruddy S, Talbott D, Norris KJ, Snieder H, George AL, Marshall V, Shakir S, Kannankeril PJ, Munroe PB, Camm AJ, Jeffery S, Roden DM, Behr ER. Common variation in the NOS1AP gene is associated with drug-induced QT prolongation and ventricular arrhythmia. J Am Coll Cardiol. 2012, Aug 28; 60(9): 841-50.
2010
Sotoodehnia N*, Isaacs A*, de Bakker PI*, Dörr M*, Newton-Cheh C*, Nolte IM*, van der Harst P*, Müller M*, Eijgelsheim M*, Alonso A*, Hicks AA*, Padmanabhan S*, Hayward C*, Smith AV*, Polasek O*, Giovannone S*, Fu J*, [75 authors], Rudan I*, Snieder H*, Wilson JF*, Pramstaller PP*, Siscovick DS*, Wang TJ*, Gudnason V*, van Duijn CM*, Felix SB*, Fishman GI*, Jamshidi Y*, Ch Stricker BH*, Samani NJ*, Kääb S*, Arking DE*. Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction. Nat Genet. 2010, Dec; 42(12): 1068-76.
*These authors contributed equally.
Eijgelsheim M, Newton-Cheh C, Sotoodehnia N, de Bakker PIW, Müller M, Morrison AC, Smith AV, Isaacs A, Sanna S, Dörr M, Navarro P, Fuchsberger C, Nolte IM, de Geus EJC, Estrada K, Hwang S, Bis JC, Rückert IM, Alonso A, Launer LJ, Hottenga JJ, Rivadeneira F, Noseworthy PA, Rice KM, Perz S, Arking DE, Spector TD, Kors JA, Aulchenko YS, Tarasov KV, Homuth G, Wild SH, Marroni F, Gieger C, Licht CM, Prineas RJ, Hofman A, Rotter JI, Hicks AA, Ernst F, Najjar SS, Wright AF, Peters A, Fox ER, Oostra BA, Kroemer HK, Couper D, Völzke H, Campbell H, Meitinger T, Uda M, Witteman JCM, Psaty BM, Wichmann HE, Harris TB, Kääb S, Siscovick DS, Jamshidi Y, Uitterlinden AG, Folsom AR, Larson MG, Wilson JF, Penninx BW, Snieder H, Pramstaller PP, van Duijn CM, Lakatta EG, Felix SB, Gudnason V, Pfeufer A, Heckbert SR, Stricker BHC, Boerwinkle E, O’Donnell CJ. Genome-wide association analysis identifies multiple loci related with resting heart rate. Human Molecular Genetics. 2010, Oct 1; 19(19): 3885-94.
Key publications
van der Harst P, van Setten J, Verweij N, Vogler G, Franke L, Maurano MT, Wang X, .... Newton-Cheh C, Hicks AA, Chambers JC, Jamshidi Y, Visel A, Christoffels VM, Isaacs A, Samani NJ, de Bakker PI. 52 Genetic Loci Influencing Myocardial Mass. J Am Coll Cardiol. 2016 Sep 27;68(13):1435-48.
Behr ER, Savio-Galimberti E, Barc J, Holst AG, Petropoulou E, Prins BP, Jabbari J, Torchio M, Berthet M, Mizusawa Y, Yang T, Nannenberg EA, Dagradi F, Weeke P, Bastiaenan R, Ackerman MJ, Haunso S, Leenhardt A, Kääb S, Probst V, Redon R, Sharma S, Wilde A, Tfelt-Hansen J, Schwartz P, Roden DM, Bezzina CR, Olesen M, Darbar D, Guicheney P, Crotti L; UK10K Consortium, Jamshidi Y. Role of common and rare variants in SCN10A: results from the Brugada syndrome QRS locus gene discovery collaborative study. Cardiovasc Res. 2015 Jun 1;106(3):520-9.
Jamshidi Y, Nolte IM, Dalageorgou C, Zheng D, Johnson T, Bastiaenen R, Ruddy S, Talbott D, Norris KJ, Snieder H, George AL, Marshall V, Shakir S, Kannankeril PJ, Munroe PB, Camm AJ, Jeffery S, Roden DM, Behr ER. Common variation in the NOS1AP gene is associated with drug-induced QT prolongation and ventricular arrhythmia. J Am Coll Cardiol. 2012, Aug 28; 60(9): 841-50.
Sotoodehnia N*, Isaacs A*, de Bakker PI*, Dörr M*, Newton-Cheh C*, Nolte IM*, van der Harst P*, Müller M*, Eijgelsheim M*, Alonso A*, Hicks AA*, Padmanabhan S*, Hayward C*, Smith AV*, Polasek O*, Giovannone S*, Fu J*, [75 authors], Rudan I*, Snieder H*, Wilson JF*, Pramstaller PP*, Siscovick DS*, Wang TJ*, Gudnason V*, van Duijn CM*, Felix SB*, Fishman GI*, Jamshidi Y*, Ch Stricker BH*, Samani NJ*, Kääb S*, Arking DE*. Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction. Nat Genet. 2010, Dec; 42(12): 1068-76.
*These authors contributed equally.
Jamshidi Y, Montgomery HE, Hense HW, Myerson SG, Torra IP, Staels B, World MJ, Doering A, Erdmann J, Hengstenberg C, Humphries SE, Schunkert H, Flavell DM. Peroxisome proliferator-activated receptor alpha gene regulates left ventricular growth in response to exercise and hypertension. Circulation. 2002, Feb 26; 105(8): 950-5.
Research group
The team in the Cardiogenetics Lab includes:
Jaipreet Bharj, PhD student, investigating gene expression changes in a zebrafish model of cardiac dysfunction
Jade Crockford, Placement student, investigating the underlying mutations for inherited cardiac and skeletal muscle conditions by exome sequencing.
Evmorfia Petropoulou, PhD student, investigating the genetics of cardiac arrhythmias using next generation sequencing
Dr Daniel Osborn, Lecturer in Genetics, who collaborates closely with the group to model cardiac and skeletal muscle disease in the zebrafish model.
Collaborations
Dr Jamshidi and colleagues in the Genome Medicine Research Lab work very closely with Professor Harold Snieder, a genetic epidemiologist with expertise in cardiovascular disease, obesity and type 2 diabetes in the Unit of Genetic Epidemiology and Bioinformatics at the University of Groningen in The Netherlands, and his colleague Dr Ilja M Nolte.
Dr Jamshidi has a long-standing collaborative relationship with Professor Tim Spector, professor of genetic epidemiology at King's College London and director of the TwinUK Registry. Dr Jamshidi has analysed genetic samples from the TwinsUK Registry as part of the Wellcome funded UK10K project's search for rare mutations associated with cardiac arrhythmias.
She also collaborates with:
Professor Patricia Munroe, William Harvey Research Institute, Barts and The London School of Medicine, UK
Nona Sotoodehnia, Associate Professor of Medicine, Division of Cardiology, Department of Medicine, University of Washington, USA
Arne Pfeufer, Institute of Genetic Medicine, European Academy of Bozen/Bolzano (EURAC), Bolzano, Italy
Chris Newton-Cheh, assistant professor of medicine at Harvard Medical School and a staff cardiologist at Massachusetts General Hospital, Boston, USA (Center for Human Genetic Research and the Cardiovascular Research Center); and
Mark Eijgelsheim, Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands.
Funding
Molecular and therapeutic mechanisms of a novel form of congenital muscular dystrophy.
Awarded to Jamshidi (PI), Osborn (Co-PI)
Newlife Charity
2017-2018
Developing a commercial zebrafish facility
Awarded to Jamshidi (PI), Osborn (Co-PI)
Impact and Innovation Award, SGUL
2015-2016
Influence of low frequency and rare variants on ECG risk traits for cardiac arrhythmias
Awarded to Jamshidi (PI)
British Heart Foundation
February 2013 to April 2015
Necrotizing enterocolitis and coagulation protein expression in neonates
Awarded to Jamshidi (co-applicant) and others
St George’s Charitable Trust
September 2012 to December 2013
International Mouse Phenotyping Consortium (IMPC)
UK research consortium
Awarded to Munroe (PI), Jamshidi (co-applicant) and others
Medical Research Council
2011 to 2014
Personalised genomic medicine: targeted sequencing for LQT disease alleles
Awarded to Jamshidi (co-applicant) and others
St George's Charitable Trust
2011 to 2012
Signal-transduction pathways involved in the hypertrophic effect of leptin in cardiomyocytes
Awarded to Jamshidi (PI)
Wellcome Trust Value in People Award
2008 to 2009
Genetic and environmental contribution to QT interval duration in the normal population: a UK twin candidate gene study
Awarded to Jamshidi (PI)
British Heart Foundation
2006 to 2010
Teaching
Dr Jamshidi has a Postgraduate Certificate in Healthcare and Biomedical Education and has taught molecular biology and genetics to medical, BSc and PhD/MRes students.
She initiated and runs the Cloning, Stem Cell Research and Regenerative Medicine module offered to medical students who choose to undertake an Intercalated BSc, and to third year Biomedical Science BSc students.
She acts as a personal tutor to both medical students and Biomedical Science BSc students, and delivers lectures about genetics to undergraduate and postgraduate students.
Yalda is the external examiner for the Genomic Medicine MSc at Exeter University.
