Dr Jamal Nasir is a senior lecturer in functional genetics at St George’s.
Dr Nasir’s two main areas of interest encompass the genetics of neuropsychiatric disorders, including schizophrenia and Parkinson’s disease, and the genetics of HIV susceptibility. He is specifically interested in dopamine – a chemical in the brain that transmits nerve impulses.
Dopamine is crucial to how the brain controls movements, and regulates the pleasure system of the brain-signalling pathway. Dr Nasir is interested in its role in normal functioning as well as in disorders involving addiction, psychosis, and cognitive and motor functions.
Dr Nasir’s specific expertise is in genetics, molecular biology and transgenic and gene knockout studies – studies involving genetically engineered organisms where one or more genes have been 'turned off'. He is currently working on the genetic mechanisms underpining schizophrenia, Parkinson’s disease, and HIV, at the molecular and cellular level. In particular, he is investigating the role of two novel dopamine receptor interacting proteins (DRIPs) (previously identified in his lab) in these disorders.
Dr Nasir is a senior lecturer in functional genetics. Previously, he was a lecturer at University of Sheffield Medical School. Prior to that, he was a Medical Research Council (MRC) Career Development Award holder within the Molecular Medicine Centre at University of Edinburgh.
Awards and honours
MRC (UK) Career Development Award (Edinburgh University).
Wellcome Trust ‘Value in People’ Award (Sheffield University).
Bioscience Yorkshire Enterprise Fellow (Yorkshire Forward).
Lingping Zhan, Jonathan R. Kerr, Maria-Jose Lafuente, Alan Maclean, Margarita V. Chibalina, Bigang liu, Beverley Burke, Steve Bevan, and Jamal Nasir (2011). Altered expression and coregulation of dopamine signalling genes in schizophrenia and bipolar disorder. Neuropathol Appl Neurobiol. 37(2):206-19.
Newbury DF, Winchester L, Addis L, Paracchini S, Buckingham LL, Clark A, Cohen W, Cowie H, Dworzynski KD, Everitt A, Goodyer IM, Hennessy E, Kindley AD, Miller LL, Nasir J, O'Hare A, Shaw D, Simkin Z, Simonoff E, Slonims V5, Watson J, Ragoussis J, Fisher SE, Seckl JR, Helms PJ6, Bolton PF, Pickles A, Conti-Ramsden G, Baird G, Bishop DVM & Monaco AP. CMIP and ATP2C2 modulate phonological short-term memory in language impairment. (2009). Am. J. Hum. Genet. 85, 264-272.
Lingping Zhan, Bigang Liu, Maria Jose-Lafuente, Margarita V Chibalina, Andrew Grierson, Alan Maclean, Ggotim Lee and Jamal Nasir. A novel dopamine receptor interacting protein linking D1 and D3 signalling (2008). Eur J Neurosci. 27 (7) 1626-33.
Xinsheng Nan, Jianghui Hou, Alan Maclean, Jamal Nasir, Maria Jose Lafuente, Xinhua Shu, Skirmantas Kriaucionis and Adrian Bird (2007). Interaction between chromatin proteins MeCP2 and ATRX is disrupted by mutations that cause inherited mental retardation. Proc. Natl. Acad. Sci. USA 104(8) 2709-14.
Sabina Sperandio, Karen Poksay, Ian de Belle, Maria Jose Lafuente, Bigang Liu, Jamal Nasir* and Dale E. Bredesen* (2004). Paraptosis: mediation by MAP kinases and inhibition by AIP-1/Alix. Cell Death and Differentiation 11 (10), 1066-1075. *
Edmond Y. W. Chan*, Jamal Nasir*, Claire-Anne Gutekunst*, Sarah Coleman, Alan Maclean, Alex Maas, Martina Metzler, Marina Gertsenstein, Christopher A. Ross, Andràs Nagy and Michael R. Hayden (2002). Targeted disruption of Huntingtin-associated protein-1 (Hap1) results in postnatal death due to depressed feeding behavior. Human Molecular Genetics 11 (8), 945-959.
Dr Kim Carter (University of Western Australia).
Dr Maria Arranz (Institute of Psychiatry, King’s College, London).
UK Specific Language Impairment Consortium (SLIC), University of Oxford.
Dr Philip Chen (Royal Holloway, University of London).
Dr Robin Williams (Royal Holloway, University of London).
Dr Nasir teaches students on the following courses:
- Pharmacy MPharm (Hons). This course is delivered by Kingston University with some modules taught at St George's
- Biomedical Science BSc (Hons)
- Medicine MBBS (graduate entry)
- Biomedical Science MRes
- Supervision of PhD students