Dr Claudia Eder’s research focuses on understanding physiological mechanisms underlying immune cell behaviour.
In particular, she is interested in the activation and de-activation mechanisms of microglial cells/brain macrophages. Her research group has identified ion channels, ion transporters and intracellular signalling pathways that are involved in microglial shape changes, production of pro-inflammatory cytokines and reactive oxygen species, and cell migration.
Her current research is aimed at understanding interactions between microglial cells and neurons in health and disease. She has a special interest in developing strategies for selectively reducing the cytotoxic effects of activated microglia following acute brain injury or during chronic inflammatory and autoimmune diseases.
Dr Eder’s studies mainly use patch-clamping, video imaging techniques (to observe morphological changes and the migration of cells; fluorescence measurements of intracellular Ca2+, Na+, pH, reactive oxygen species and caspase activity), and immunological techniques (e.g. ELISA).
Schilling T. & Eder C. Sodium dependence of lysophosphatidylcholine-induced caspase-1 activity and reactive oxygen species production. Immunobiology, 216: 118-125, 2011.
Eder C. Ion channels in monocytes and microglia / brain macrophages: promising therapeutic targets for neurological diseases. J. Neuroimmunol., 224: 51-55, 2010.
Eder C. Mechanisms of interleukin-1beta release. Immunobiology, 214: 543-553, 2009.
Stock C., Schilling T., Schwab A and Eder C. Lysophosphatidylcholine stimulates IL-1beta release from microglia via a P2X7 receptor-independent mechanism. J. Immunol., 177: 8560-8568, 2006.
Schilling T., Lehmann F., Rueckert B. & Eder C. Physiological mechanisms of lysophosphatidylcholine-induced de-ramification of murine microglia. J. Physiol., 557: 105-120, 2004.
Eder C. & DeCoursey T.E. Voltage-gated proton channels in microglia. Prog. Neurobiol. 64: 277-305, 2001.
Dr Eder is currently collaborating with Professor David Attwell of University College London.