Research
Dr Angela Loyse is an Academic Clinical Lecturer in Infection and Immunity.
Her substantive research training and interest is in Cryptococcus and cryptococcal meningitis, as part of the Cryptococcal Meningitis Group at St George’s. She conducted a clinical trial of combination antifungal therapy in HIV-associated cryptococcal meningitis in South Africa, from 2006 to 2009 (principal investigator Professor Tom Harrison) as part of her MD(Res) thesis.
Dr Loyse is a Lead Investigator on the MRC/ANRS-funded phase III ACTA trial and was instrumental in obtaining the Agence Nationale de Recherches sur le Sida et les hépatites virales (ANRS) funding for the Cameroon sites of this multicentre African trial. She has been heavily involved in trial set up in close collaboration with the international trial coordinator, Dr Sile Molloy, and is particularly interested in the interface between clinical research and capacity building.
She chairs an advocacy group whose aim is to improve access to essential antifungals in resource poor settings. Members include partners from WHO, CDC, Medecins Sans Frontieres, CHAI (Clinton Health Access Initiative) and GAFFI (Global Action Fund for Fungal Infections).
Her current aim is to finish clinical training in infectious diseases and pursue a career in public health and HIV-related clinical and operational research.
Biography
She first became interested in infectious diseases research whilst at King’s College London medical school. Her specialist postgraduate clinical training in infectious diseases is ongoing at St George’s University Hospitals NHS Foundation Trust (start date 2009).
Publications
Angela Loyse, Thangaraj H, Easterbrook P, Ford N, Roy M, Chlller T, Govender N, Harrison TS, Bicanic T. Cryptococcal meningitis: improving access to essential antifungal medicines in developing countries. Lancet Infect Dis 2013; 13(7):629-37.
Angela Loyse, D. Wilson, G. Meintjes et al. Comparison of the early fungicidal activity of high dose fluconazole, voriconazole, and flucytosine, as second drugs given in combination with amphotericin B, for the treatment of HIV-associated cryptococcal meningitis. Clinical Infectious Diseases 2011; 54(1):121-8.
Angela Loyse, Tihana Bicanic, Joseph N Jarvis. Combination Antifungal Therapy for Cryptococcal Meningitis. NEJM 2013; 368:2522-2523.
Angela Loyse, Françoise Dromer, Jeremy Day et al. Flucytosine and cryptococcosis: time to urgently address the worldwide accessibility of a 50-year-old antifungal. Journal of Antimicrobial Chemotherapy 2013; 68(11):2435-44.
Angela Loyse, Wainwright H, Jarvis J et al. Histopathology of the arachnoid granulations and brain in HIV-associated cryptococcal meningitis: correlation with cerebrospinal fluid pressure. AIDS 2010; 24 (3): 405–410.
