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Dr Philip Goff

Research Technician
Manager of Functional Genomics Cell Bank and PhD student.
Neuroscience & Cell Biology Research Institute
02087255211
pgoff@sgul.ac.uk
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Overview

I am the manager of the Functional Genomics Cell Bank at St. George's, University of London. This resource is a mammalian cell bank at St George's, University of London, in association with the research group of Dot Bennett and Elena Sviderskaya in the Cell Biology and Genetics Research Section . The bank specialises in mouse melanocyte and melanoblast lines carrying a variety of pigmentary mutations. Other cell types include melanoma cell lines, fibroblasts, keratinocytes, mammary epithelial cells, myoblasts, and immortal human melanocytes.

I have recently passed my PhD under the supervision of Elena Sviderskaya, focusing on disorders of melanosome biogenesis.

Publications

  • Goff, P. S., Castle, J. T., Kohli, J. S., Sviderskaya, E. V., & Bennett, D. C. (2023). Isolation, Culture, and Transfection of Melanocytes. Curr Protoc, 3(5), e774.

     

    Woodcock, E., Gorelkin, P. V., Goff, P. S., Edwards, C. R. W., Zhang, Y., Korchev, Y., & Sviderskaya, E. V. (2023). Measuring Melanoma Nanomechanical Properties in Relation to Metastatic Ability and Anti-Cancer Drug Treatment Using Scanning Ion Conductance Microscopy. Cells, 12(19).

     

    Chen, Q., Zhou, D., Abdel-Malek, Z., Zhang, F., Goff, P. S., Sviderskaya, E. V., Wakamatsu, K., Ito, S., Gross, S. S., & Zippin, J. H. (2021). Measurement of Melanin Metabolism in Live Cells by [U-(13)C]-L-Tyrosine Fate Tracing Using Liquid Chromatography-Mass Spectrometry. J Invest Dermatol, 141(7), 1810-1818 e1816.

     

    Alzahofi, N., Welz, T., Robinson, C. L., Page, E. L., Briggs, D. A., Stainthorp, A. K., Reekes, J., Elbe, D. A., Straub, F., Kallemeijn, W. W., Tate, E. W., Goff, P. S., Sviderskaya, E. V., Cantero, M., Montoliu, L., Nedelec, F., Miles, A. K., Bailly, M., Kerkhoff, E., & Hume, A. N. (2020). Rab27a co-ordinates actin-dependent transport by controlling organelle-associated motors and track assembly proteins. Nat Commun, 11(1), 3495.

     

    Zhang, Y., Takahashi, Y., Hong, S. P., Liu, F., Bednarska, J., Goff, P. S., Novak, P., Shevchuk, A., Gopal, S., Barozzi, I., Magnani, L., Sakai, H., Suguru, Y., Fujii, T., Erofeev, A., Gorelkin, P., Majouga, A., Weiss, D. J., Edwards, C., . . . Korchev, Y. (2019). High-resolution label-free 3D mapping of extracellular pH of single living cells. Nat Commun, 10(1), 5610.

     

    Dennis, M. K., Delevoye, C., Acosta-Ruiz, A., Hurbain, I., Romao, M., Hesketh, G. G., Goff, P. S., Sviderskaya, E. V., Bennett, D. C., Luzio, J. P., Galli, T., Owen, D. J., Raposo, G., & Marks, M. S. (2016). BLOC-1 and BLOC-3 regulate VAMP7 cycling to and from melanosomes via distinct tubular transport carriers. J Cell Biol, 214(3), 293-308.

     

    Cao, J., Dai, X., Wan, L., Wang, H., Zhang, J., Goff, P. S., Sviderskaya, E. V., Xuan, Z., Xu, Z., Xu, X., Hinds, P., Flaherty, K. T., Faller, D. V., Goding, C. R., Wang, Y., Wei, W., & Cui, R. (2015). The E3 ligase APC/C(Cdh1) promotes ubiquitylation-mediated proteolysis of PAX3 to suppress melanocyte proliferation and melanoma growth. Sci Signal, 8(392), ra87.

     

    Godwin, L. S., Castle, J. T., Kohli, J. S., Goff, P. S., Cairney, C. J., Keith, W. N., Sviderskaya, E. V., & Bennett, D. C. (2014). Isolation, culture, and transfection of melanocytes. Curr Protoc Cell Biol, 63, 1 8 1-20.

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