Find out more about the investigators and the wider Global Health team working on the featured projects.

Global Health team

Investigators 

Tom Harrison

Professor of Infectious Diseases and Medicine, Tom Harrison, focuses his research on fungal disease cryptococcal meningitis, in particular the human immune response and clinical prevention and management of disease.

Professor Harrison studied medicine at St George’s, University of London. His work also includes the development of new clinical treatments for TB.

Management, immunology and the prevention of cryptococcal meningitis is being addressed by his group.

Amina Jindani

Dr Amina Jindani is an Honorary Senior Lecturer at St George’s. Her work includes clinical trials of tuberculosis, which she has been involved in since the 1960s.

An international trail conducted by Dr Jundani led to changes in the recommendations by the World Health Organisation (WHO) for the treatment of tuberculosis.

She coordinated the first East African/British Medical Research Council trial of short-course chemotherapy in Africa.

Tihana Bicanic

Dr Tihana Bicanic has performed clinical trials of combination antifungal therapy in HIV-associated cryptococcal meningitis at the University of Cape Town, South Africa, and now focuses on the contribution of cryptococcal variation to clinical disease and outcome in humans.

For her MD(Res) degree at St George’s, Tihana performed clinical trials of combination antifungal therapy in HIV-associated cryptococcal meningitis at the University of Cape Town, South Africa, with Professor Tom Harrison. These generated a large number of cryptococcal isolates linked to clinical data, which form the focus of her current research on the contribution of variation in the properties of the infecting cryptococcal strain to clinical presentation and outcome in human cryptococcosis.

Dr Bicanic has been awarded a postdoctoral fellowship project award through a Wellcome Trust Strategic Award in Medical Mycology and Fungal Immunology (WTSA MMFI), to look at the human immunogenetics of susceptibility to, and severity of, cryptococcal meningitis in patients with advanced HIV (2013), as well as a WTSA MMFI clinical fellowship award to look at the relationship between antifungal PK/PD and resistance and microbiologic outcome in patients treated with fluconazole-based regimens for cryptococcal meningitis (2014).

She is a co-investigator on the phase III Advancing Cryptococcal meningitis treatment trial. Together with other members of the group and partners from the World Health Organisation, Centers for Disease Control, Medecins Sans Frontieres, and others, she is involved in advocacy to improve access to antifungals in developing countries.

Angela Loyse

Dr Angela Loyse is an Academic Clinical Lecturer in Infection and Immunity. Whilst at King’s College London medical school, she became interested in the research of infectious diseases.

Her interest is in Cryptococcus and cryptococcal meningitis, as part of the Cryptococcal Meningitis Group at St George’s.

From 2006 to 2009 she conducted a clinical trial of combination antifungal therapy in HIV-associated cryptococcal meningitis in South Africa.

Sile Molloy

Dr Sile Molloy is the Epidemiologist and International Project Manager for cryptococcal meningitis (CM) treatment trials conducted in 11 sites across five countries in Sub-Saharan Africa (SSA).

Her work focuses on conducting phase II/III clinical trials (ACTA/ Ambition) to improve outcomes for patients treated for CM in various low-resource settings across SSA. Dr Molloy’s main research interests are in improving the standard of care for CM patients in resource-limited settings. She is particularly interested in implementation research and improving access to essential medicines, in addition to research on clinical trial design, implementation and analysis. She is co-investigator on the DREAMM project which aims to implement current World Health Organization (WHO) guidelines for screening and treatment of meningoencephalitis in three sites across SSA.

She is also an active member of the CryptoMAG group; an advocacy group which aims to reduce the CM related mortality through roll-out of effective screening programmes and improving access to essential antifungals and diagnostics tests across SSA. The group consists of members from St George's, University of London, MSF, WHO, Centers for Disease Control and Prevention (CDC), and Clinton Health Access Initiative (CHAI).

Postdoctoral Researchers 

Shichina Kannambath

Shichina is a postdoctoral research associate working with Dr Tihana Bicanic, Prof Tom Harrison and Mihai Netea (Radboud University, Netherlands). Her research focuses on host immune response against fungal pathogen, Cryptococcus. She conducts genome-wide association study (GWAS) to understand genetic susceptibility to cryptococcal meningitis in advanced HIV patients from Sub-Saharan Africa. In addition, she is also performing transcriptomics analysis of peripheral blood mononuclear cell (PBMCs) from healthy individuals to understand the biological pathways involved in human immune response against Cryptococcus.

Shichina completed her PhD in Systems Biology at University of Manchester. She then worked as a postdoctoral fellow in bioinformatics at Imperial College London before joining St George’s. She is interested in interdisciplinary research particularly in bioinformatics analysis of next generation sequencing.

At St George’s, together with three fellow researchers, she started ‘Postdoctoral Forum’ a platform for postdoctoral scientists at St George’s, University of London to network and share their ideas.

Project Management 

Claire Robb

International Clinical Project Manager, Claire, works primarily on the RIFASHORT Trial, an international, phase III treatment trial aiming to shorten treatment duration for tuberculosis. RIFASHORT is conducted in several sites across Africa and South America. Claire manages all aspects of this trial with support from Jack and Sarah.

In addition, Claire provides oversight and support for the conduct of other trials and projects within the Centre for Global Health, and supervises junior members of the team.

Claire has more than eight years’ experience in the field of clinical research having worked both for pharmaceutical companies and within other academic institutions. Directly prior to joining St George’s, Claire worked at the Medical Research Council Clinical Trials Unit as a Trial Manager on a large phase III oncology trial.

In 2016 Claire ran the London Marathon and raised £5,000 for ‘World Without TB’, a charity run by Dr Amina Jindani.

Claire holds a BSc (Hons) in Neuroscience from Kings College, University of London, UK.

Muirgen Stack

Muirgen is an International Clinical Project Manager focusing on the DREAMM study. He was previously working as a Clinical Programs Advisor and Research Manager for the Australasian Society for HIV Medicine (ASHM). He was responsible for providing technical and clinical advice across the HIV, viral hepatitis and STIs programme areas. This included capacity building and health systems strengthening projects throughout South East Asia and the Pacific. In addition, he has experience in medical education program development including curriculum design for LMICs.

Muirgen holds a BSc (Honours) in Virology and Cancer Biology from the University of Bristol, UK.

Jack Adams

Jack started his current role with the Centre for Global Health, within the Institute for Infection and Immunity at St George’s, in June 2016, working as an International Data Manager for two major phase III clinical trials. These projects are looking at novel drug regimens for the treatment of cryptococcal meningitis and tuberculosis and are taking place throughout Sub-Saharan Africa and South America.

Previously Jack has worked as a Trial Assistant on two major observational studies for King’s College London, for which he recruited and consented participants and contributed to data processing and management.

His main interests are the management and co-ordination of clinical trials as well finding solutions to international data management issues and in doing so building capacity with international collaborators.

Sarah Burton

Sarah works as a Clinical Trial Assistant across various studies, including two large phase III trials; RIFASHORT and ACTA. As a new member of the team, she is keen to learn more about the management and organisation of international studies.

Sarah previously worked in an NHS Blood Sciences laboratory as a Biomedical Assistant. She graduated from the University of Huddersfield in 2015 with a first class degree in Human Biology (BSc).


Last Updated: Friday, 11 August 2017 13:48