Dr David Winterbourne has been at St George’s since 1979. He is the chief examiner for year 1 of the five year Medicine MBBS and the joint lead for the Basic and Clinical Sciences theme.
Dr Winterbourne is the developer of CRAM, a suite of networked programs for curriculum and assessment management. He is the coordinator for several sub-modules taught in the five year Medicine MBBS programme and is the Biological Safety Officer for Genetic Modification.
Dr Winterbourne did postdoctoral work at the National Cancer Institute, Bethesda, Maryland between 1976 and 1979 after obtaining his doctorate from the University of Oxford. Prior to that he gained a first class honours degree in Biological Chemistry from the University of Manchester.
Dr Winterbourne is involved in teaching the first two years of undergraduate medicine and years 1 to 3 of the Biomedical Science BSc. He also teaches on the first year of the Master of Pharmacy course at Kingston University.
As well as lectures in molecular and cellular biology, Dr Winterbourne delivers case-based learning tutorials and various subject specific tutorials. He is the five year Medicine MBBS module coordinator for the Musculoskeletal System and Cancer models within the Mechanisms of Disease module. He is also joint lead for the Basic and Clinical Sciences module. He has coordinated the teaching of Bioinformatics in the third year of the BSc Biomedical Science and Intercalated BSc programmes between 2000 and 2013, and currently runs a practical class on this topic for the Master of Pharmacy course.
Dr Winterbourne has been involved in the management of assessment since 2000 and is currently the chief examiner for year 1 of the five year Medicine MBBS.
- Winterbourne DJ and Weingast Johnson J (1994). Purines induce lipofuscin formation in a colon carcinoma cell line. Biochem. J. 301, 373 377.
- Winterbourne DJ, Thomas S, and Hermon Taylor J (1993). Suppression of anchorage independent growth after gene transfection. Br. J. Cancer 68, 251 258.
- Winterbourne DJ and Mora PT (1981). Cells selected for high tumourigenicity or transformed by simian virus 40 synthesize heparan sulphate with reduced degree of sulphation. J. Biol. Chem. 256, 4310 4320.
Dr Winterbourne conceived and developed CRAM, a suite of networked programs for curriculum and assessment management. CRAM is widely recognised as playing a key role in the management of teaching activities at St George’s. It generates handbooks and timetables for seven teaching programmes and builds and maintains pages in the virtual learning environment, Moodle. CRAM also generates calendars with direct links to these learning resources. Other parts of the application are used to prepare exam papers, calculate results, and produce item analysis and other reports on assessments in the five year Medicine MBBS and Biomedical Sciences courses. The program is designed to produce detailed feedback for each student, which is also sent to personal tutors, giving them a real insight into their tutees’ progress.
Dr Winterbourne has developed other computer programs, including a system to optimally allocate students to modules based on their selections and a system to allow searching learning objectives indexed by Medical Subject Headings (MeSH) terms.
As the Biological Safety Officer for genetic modification, David provides advice to individuals planning to work with genetically modified organisms and coordinates assessments of the risks of such work. He is the main contact between St George's and the Health and Safety Executive for issues related to Genetic Modification.
David has an interest in the molecular changes that give rise to cancer and underlie the unregulated growth of cancer cells. For the former, he is investigating the structure and function of xanthine oxidoreductase (XOR), an enzyme that may play a role in the development of cancer by the formation of damaging free radicals. For the latter, he is studying the suppression of anchorage-independent growth - an abnormal type of growth that is characteristic of cancer cells.