Dr Walley was appointed as Senior Lecturer in Human Genomics in 2015. Prior to this, he was at Imperial College London where he held the posts of Lecturer in Complex Human Genetics (2005-2015) and Genome Centre Manager (2003-2005).
At Imperial College London, Dr Walley’s teaching roles included Course Director of the MSc in Human Molecular Genetics and Co-Course Director of the short course “Principles of Genomic Medicine”. He was also Module leader for the “Omics Techniques” module for the MSc in Genomic Medicine and Lecturer and examiner for the “Genetics” module of the first year MBBS/BMS undergraduate and graduate entry MBBS degree courses. He was awarded the Postgraduate Certificate in Advanced Student Learning and Teaching from Imperial College London in 2007.
Before moving to Imperial College London, he held three consecutive postgraduate research posts at the University of Oxford, working in the Wellcome Trust Centre for Human Genetics, the John Radcliffe Hospital and the Weatherall Institute of Molecular Medicine.
Dr Walley obtained both his undergraduate honours degree in biochemistry and his Ph.D. in virology from the University of Oxford.
Dr Walley is lecturing on human genomics for the 2nd year BSc Biomedical Science/MBBS shared teaching and the 3rd Year BSc Biomedical Science/Intercalated Human Medical Genetics module.
He is contributing to the admissions process by taking part as a Multi-Mini-Interviews assessor for the MBBS5 and MBBS4 courses.
He supervises Year 3 Biomedical Sciences lab projects and Year 2 Special Study Project 1 (SSP1) literature projects.
He is involved in both the “Omics Technologies” and “Research Project” modules of the new MSc in Genomic Medicine
He is co-editor of an online course, in collaboration with Professor Blakemore of Imperial College London, for Henry Stewart Talks. He also lectures as part of the MSc in Paediatrics and Child Health at University College London.
Cartwright R, Kirby AC, Tikkinen KA, Mangera A, Thiagamoorthy G, Rajan P, Pesonen JS, Ambrose C, Gonzalez-Maffe J, Bennett P, Palmer T, Walley A, Järvelin MR, Chapple C, Khullar V (2014). Systematic review and meta-analysis of genetic association studies of urinary symptoms and prolapse in women. Am J Obstet Gynecol. 212(2):199.e1-199.e24
Falchi M, El-Sayed Moustafa J, Takousis P, … Walley A, Eichler EE, Pattou F, Spector TD and Froguel P (2014). Low number of copies of the salivary amylase gene predisposes to obesity. Nature Genet 46(5):492-7
Boardman JP, Walley A, Ball G, Takousis P, Krishnan ML, Hughes-Carre L, Aljabar P, Serag A, King C, Merchant N, Srinivasan L, Froguel P, Hajnal J, Rueckert D, Counsell S and Edwards AD (2014). Common genetic variants modulate risk of brain injury after preterm birth. Pediatrics 133(6):e1655-63
El-Sayed Moustafa JS, Eleftherohorinou H, de Smith AJ, … Walley A, Falchi M, Froguel P, Blakemore AIF and Coin LJM (2012). Novel Association Approach for Variable Number Tandem Repeats (VNTRs) Identifies DOCK5 as a Susceptibility Gene for Severe Obesity. Hum Mol Genet 21(16):3727-38
Khor CC, Vannberg FO, Chapman SJ, Guo H, Wong SH, Walley A, …Fine PEM, Goh D, Hill AVS (2010). CISH and Susceptibility to Infectious Diseases. New Engl J Med 362(22):2092-101
Walters RG, Jacquemont S, Valsesia A, de Smith AJ, … Walley AJ, Coin LJ, Blakemore AI, Froguel P, Beckmann JS (2010). A novel highly-penetrant form of obesity due to a 740kb deletion on chromosome. 16p11.2” Nature 463:671-5
Clark SJ, Falchi M, Olsson B, … Carlsson LMS, Froguel P and Walley A.J (2011). Association of Sirtuin 1 (SIRT1) gene SNPs and transcript expression levels with severe obesity. Obesity 20(1):178-85
Walley AJ, Chavanas S, Moffatt MF… Harper JI, Hovnanian A and Cookson WOCM (2001) Gene polymorphism in Netherton and common atopic disease. Nature Genet 29:175-178
Walley AJ, Barth ML, Ellis I, Fensom AH and Harris A (1993). Gaucher's disease in the United Kingdom: screening non-Jewish patients for the two common mutations. J Med Genet 30:280-283.
Dr Walley is collaborating on the following projects:
Genetics of Urinary Incontinence – Dr Rufus Cartwright - Imperial College London
Complex traits and lifecourse epidemiology - Professor Marjo-Riitta Jarvelin - Imperial College London
Obesity and Bariatric Surgery Outcomes - Professor Alex Blakemore - Imperial College London
Genetics of Obesity and Exercise - Dr Una Fairbrother – London Metropolitan University and Professor Patricio Lopez-Jaramillo - Santander University, Colombia
Genetics and Imaging - Professor David Edwards – Kings College London and Dr James Boardman – University of Edinburgh
Dr Walley’s research has focused for a long time on genomic approaches for identifying variation in the human genome associated with susceptibility to common disease. This includes single nucleotide polymorphism and copy number variation, gene expression measurement and characterising disease-related changes in DNA methylation patterns. Over the course of his career he has worked on the genetics and genomics of a wide range of human diseases, including HIV, Gaucher’s Disease, asthma, malaria, obesity, neonatal encephalopathy and urinary incontinence.
He has over seventy publications, including three reviews and three book chapters. He has held two grants as Principal Investigator (Wellcome Trust and Diabetes UK) and has been Co-Investigator on six. He has presented at many conferences, including talks at the American Society for Human Genetics and European Society for Human Genetics meetings.
He co-supervised two PhD students who gained their degrees in 2013, with a third due to complete in 2015. The students who completed both went on to postdoctoral positions at the University of Cambridge. He has also supervised numerous MSc projects.