Name: Shirley V. Hodgson
Position: Professor of cancer genetics
Tel: +44 (0)20 8725 5279
Genetic cancer susceptibility, colorectal and breast cancers, endometrial cancer in women with Lynch Syndrome (HNPCC), Mirena IUS, carcinogenesis in colorectal polyps.
We have been examining genetic and epigenetic – where a cell, organ or individual is changed without its DNA being directly affected – changes in pre-malignant colonic lesions –abnormal tissue on the colon – in order to understand what drives these lesions forward into cancer, as well as studying germline susceptibilities that may predispose people to develop pre-malignant lesions such as adenomas – benign tumours of glandular origin.
Current projects include a collaboration with colleagues in Nepal Medical College, notably Dr Manohar Lal Shresthra, to ascertain individuals with novel genetic disorders from isolated inbred communities, for genetic studies in collaboration with Professor Andrew Crosby at SGUL. We are also testing families with multiple cases of papillary thyroid cancer for genetic variants which could contribute to a susceptibility to this cancer.
As part of a multidisciplinary clinic with Dr Gul Bano at St Georges, we are ascertaining individuals with novel syndromes causing a susceptibility to endocrine tumours and paragangliomas, with the aim of identifying new genetic endocrine tumour susceptibility genes and optimising management protocols for these individuals.
1998-2003 Reader in Clinical Genetics KCL and Honorary Consultant, Guy’s and St Thomas’ Hospital NHS Trust.
1990-1998 Senior Lecturer in Clinical Genetics, Division of Medical and Molecular Genetics, United Medical and Dental Schools of Guy’s and St Thomas’s Hospitals (UMDS, now GKT) and Honorary Consultant Clinical Geneticist, South Thames (East) Regional Genetics Centre, Guy’s and St Thomas’ Hospital NHS Trust, Guy’s Hospital.
1988-1990 Consultant Clinical Geneticist, East Anglian Regional Genetics Centre, Addenbrooke’s Hospital, Cambridge.
1983-1988 Senior Registrar (Clinical Genetics), South Thames (East) Regional Genetics Centre, Guy’s Hospital and Honorary Senior Registrar at Hammersmith Hospital, London.