Dr Thomas Barrick is currently Senior Lecturer in MR Image Analysis at St George's, University of London and leads the magnetic resonance (MR) image analysis team of the Stroke and Dementia Research Centre.
His research concentrates on the development of MR image acquisition and analysis techniques and their application to clinical multi-modal MR imaging studies.
His current focus is on the development and application of novel anomalous diffusion MR image acquisition and analysis techniques that are capable of quantifying tissue complexity in the brain.
These new techniques provide information beyond the standard Gaussian diffusion models that are commonly applied in diffusion MR imaging and have great potential to offer new insights and clinically relevant information regarding pathological disease processes.
Dr Barrick joined St George's in August 2001 specialising in multimodal MR and, in particular, diffusion MR image analysis techniques.
Prior to this Dr Barrick graduated with first class honours in mathematics at the University of Liverpool in 1996 where he also received a distinction for his MSc in pure mathematics in 1997. He gained his PhD under Professor Neil Roberts at the Magnetic Resonance Image Analysis Centre (MARIARC), Liverpool University, studying the development and application of MR image analysis techniques to quantification of cerebral asymmetry.
Dr Barrick was a post-doctoral researcher in the Stroke and Dementia Research Centre at St George's, from 2001 to 2006. He was promoted to Lecturer in MR Image Analysis and further promoted to Senior Lecturer in 2009.
Lamar M, Charlton RA, Ajilore O, Zhang A, Yang S, Barrick TR, Rhodes E, Kumar A. Prefrontal vulnerabilities and whole brain connectivity in aging and depression. Neuropsychologia. 2013, 51(8):1463-70.
Lawrence AJ, Patel B, Morris RG, MacKinnon AD, Rich PM, Barrick TR, Markus HS. Mechanisms of cognitive impairment in cerebral small vessel disease: multimodal MRI results from the St George's cognition and neuroimaging in stroke (SCANS) study. PLoS One, 2013, 22;8(4).
Brittain JF, McCabe C, Khatun H, Kaushal N, Bridges LR, Holmes WM, Barrick TR, Graham D, Dominiczak AF, Mhairi Macrae I, Hainsworth AH. An MRI-histological study of white matter in stroke-free SHRSP. Journal Cerebral Blood Flow Metabolism, 2013, 33(5):760-3.
Patel B, Lawrence AJ, Chung AW, Rich P, Mackinnon AD, Morris RG, Barrick TR, Markus HS. Cerebral microbleeds and cognition in patients with symptomatic small vessel disease. Stroke. 2013, 44(2):356-61.
Dodd JW, Chung AW, van den Broek MD, Barrick TR, Charlton RA, Jones PW. Brain structure and function in chronic obstructive pulmonary disease: a multimodal cranial magnetic resonance imaging study. Am J Respir Crit Care Med. 2013, 186(3):240-5.
Powell JL, Parkes L, Kemp GJ, Sluming V, Barrick TR, García-Fiñana M. The effect of sex and handedness on white matter anisotropy: a diffusion tensor magnetic resonance imaging study. Neuroscience. 2013, 207:227-42.
Hall MG, Barrick TR. Two-step anomalous diffusion tensor imaging. NMR in Biomedicine. 2012, 25(2):286-94.
Barrick TR, Charlton RA, Clark CA, Markus HS. White matter structural decline in normal ageing: a prospective longitudinal study using tract based spatial statistics. NeuroImage. 2010, 51(2):565-77.
Lawes INC, Barrick TR, Murugam V, Spierings N, Evans DR, Song M, Clark CA, 2008. Atlas based segmentation of white matter tracts of the human brain using diffusion tensor tractography and comparison with classical dissection. NeuroImage. 2008, 39 (1): 62-79.
The magnetic resonance (MR) image analysis team comprises:
Dr Christian Lambert (comparative anatomy using MRI);
Dr Andrew Lawrence (longitudinal study of multimodal MRI in cerebral small vessel disease);
Dr Guang Yang (longitudinal study of multimodal MRI of brain tumours).
There are currently four PhD students within the team:
Dr Philip Benjamin (longitudinal study of multimodal MRI in cerebral small vessel disease;
Felix Raschke (multimodal MRI of brain tumours);
Owen Williams (diffusion segmentation [DSEG] in longitudinal studies of normal ageing and cerebral small vessel disease);
Eva Zeestraten (longitudinal study of multimodal MRI in cerebral small vessel disease).
Dr Barrick has collaborative relationships in the UK and America:
Professor Mhairi Macrae, professor of neuroscience (stroke and brain imaging), University of Glasgow, Scotland;
Professor Richard Magin, department head, Department of Bioengineering, University of Illinois at Chicago, USA;
Dr Melissa Lamar, associate professor of psychology in psychiatry, University of Illinois at Chicago, USA;
Dr Rebecca Charlton, lecturer in psychology, Goldsmiths, University of London;
Dr Matt Hall, senior research associate, Centre for Medical Image Computing, University College London, UK;
Professor Hugh Markus, Department of Clinical Neurosciences, University of Cambridge.
At St George's, he works collaboratively with colleagues in the Stroke and Dementia Research Centre – including Dr Peter Garrard, reader in neurology; Dr Atticus Hainsworth, senior lecturer in cerebrovascular disease; Dr Franklyn Howe, reader in MRI; colleagues in the Cardiovascular Sciences Research Centre – including Dr Taigang He, Senior lecturer of cardiovascular imaging; and in the Biomedical Sciences Research Centre – Dr Nidhi Sofat. He also works with Dr Leslie Bridges, consultant neuropathologist at St George's Hospital.
How intensively should we treat blood pressure in established cerebral small vessel disease?
Awarded to HS Markus, GA Ford, TR Barrick, J Birns, A Blamire, RG Morris, J O'Brien
2011 to 2014, £1 million
MRI biomarkers of low grade glioma growth and infiltration
Awarded to FA Howe, TR Barrick, T Jones, BA Bell
Cancer Research UK
2012 to 2015, £273,000
A novel technique for more accurate detection of age-related brain lesions and prediction of future cognitive decline
Awardded to TR Barrick, HS Markus, A Hainsworth
Research into Ageing PhD studenship
2013 to 2015, £77,250
Blood brain barrier neuropathology, white matter lesions and dementia
Awarded to A Hainsworth, S Wharton, TR Barrick, P Ince
2012 to 2014, £180,000
Dr Barrick teaches on the Biomedical Science BSc: he lectures on advanced magnetic resonance imaging techniques.
He supervises third year projects Biomedical Science undergraduate projects as well as MSc research projects and PhD students.