Dr Tarek Antonios is the lead clinician and head of the Blood Pressure Unit and the Centre of Microvascular Research.
His research interests include the small blood vessels abnormalities in the pathogenesis of cardiovascular disease particularly the role of capillary abnormalities in the causation of essential hypertension, pregnancy-associated hypertension, pre-eclampsia, and microvascular angina. Dr Antonios has shown that the microvascular abnormalities and in particular the reduction in capillary numbers in hypertension is likely to be a primary structural abnormality that occurs before the onset of hypertension and likely to be causing the increase in blood pressure.
Recently Dr Antonios discovered a more accurate way to predict pre-eclampsia by measuring the changes in capillaries in early pregnancy. Dr Antonios presented this study at the ACC 2013 meeting in San Francisco where he won the best study award.
Dr Antonios’ leading edge research has significantly contributed to a Hypertension Centre of Excellence accreditation for the Blood Pressure Unit at St George’s University Hospitals NHS Foundation Trust by the European Society of Hypertension.
As the Blood Pressure Unit’s lead consultant, Dr Antonios received the Hypertension Centre of Excellence Diploma at the European Society of Hypertension annual scientific meeting in Milan, Italy, in June 2013.
As part of the core assessment criteria the unit showed that it provides continuing medical education opportunities, has published peer reviewed research in scientific journals, trains large number of staff and is led by clinicians recognised internationally for hypertension research and care. The unit is already a Centre for Microcirculatory Research in recognition of the extensive research that Dr Antonios has produced, specifically in the field of capillary microcirculation in essential hypertension and pre-eclampsia.
The Centre of Microvascular Research, which Dr Antonios leads, is recognised by the European Society of Hypertension as a centre of excellence in hypertension management. Dr Antonios is an accredited clinical hypertension specialist of the European Society of Hypertension.
Dr Antonios joined St George’s, University of London in 1993. He was appointed as a senior registrar and honorary lecturer in clinical pharmacology and therapeutics and in general medicine in 1996. Between 1996 and 2000 he undertook clinical research funded by the British Heart Foundation studying the microcirculation in cardiovascular disease. He was admitted to the degree of doctor of medicine by the University of London in 1999 and was appointed in his current post in 2000. He became a fellow of the Royal College of Physicians and European Society of Cardiology in 2008.
Dr Antonios is internationally acclaimed in this field of microcirculation research, and has lectured in several international conferences. Dr Antonios has given invited lectures in France, Spain, Italy, Czech Republic, South Korea, Egypt, Yemen, Lebanon, and Morocco.
Dr Antonios’ clinical interests include the management of severe and resistant hypertension, secondary hypertension, malignant hypertension, pregnancy-associated hypertensive disorders including preeclampsia, and hypertensive heart failure.
Antonios TFT, Nama V Wang D, Manyonda IT. Microvascular remodelling in Preeclampsia; quantifying capillary rarefaction accurately and independently predicts preeclampsia. Am J Hypertens 2013;doi: 10.1093/ajh/hpt087
Antonios TFT, Raghuraman RP, D’Souza R, Nathan P, Wang D, Manyonda IT. Capillary Remodeling in Infants Born to Hypertensive Pregnancy: Pilot Study. Am J of Hypertension 2012; 25(8): 848-853
Nama V, Manyonda IT, Onwude J, Antonios TF. Structural capillary rarefaction and the onset of preeclampsia. Obstet & Gynecol 2012;119(5):967-974
Nama V, Antonios TF, Onwude J, Manyonda IT. Capillary remodelling in normal pregnancy: Can it mediate the progressive but reversible rise in blood pressure? Novel insights into cardiovascular adaptation in pregnancy. Hypertension Pregnancy 2012 doi:10.1016/j.preghy.2012.01.010
D'Souza R, Raghuraman RP, Nathan P, Manyonda IT, Antonios TF. Low birth weight infants do not have capillary rarefaction at birth: implications for early life influence on microcirculation. Hypertension 2011; 58. 847-851.
FJ He, M Marciniak, ND Markandu, Antonios TFT, GA MacGregor. Effect of modest salt reduction on skin capillary rarefaction in white, black and Asian individuals with mild hypertension. Hypertension 2010; 56: 253-259
Antonios TF, Nama V, Wang D, Manyonda IT. Microvascular Remodelling in Preeclampsia: Quantifying Capillary Rarefaction Accurately and Independently Predicts Preeclampsia. Am J Hypertens 2013;doi: 10.1093/ajh/hpt087
Antonios TFT, Singer DR, Markandu ND, Mortimer PS, MacGregor GA. Rarefaction of skin capillaries in borderline essential hypertension suggests an early structural abnormality. Hypertension 1999;34:655-8.
Antonios TFT, Singer DR, Markandu ND, Mortimer PS, MacGregor GA. Structural skin capillary rarefaction in essential hypertension. Hypertension 1999;33:998-1001.
Mr Vivek Nama - Microvascular Circulation in Pregnancy-Associated Hypertensive Disorders.
Mr Rohan D’Souza - The Microcirculation in Newborn Infants.
Mr Rajendra Raghuraman - Effects of an Angiotensin Receptor Antagonist Candesartan versus a calcium channel blocker Amlodipine on Microvascular Rarefaction, Endothelial Dysfunction and Microalbuminuria in Essential Hypertension.
Mr Rajendra Raghuraman and Mrs Nansi Botros -
The Role Of Capillary Microcirculation In The Pathogenesis Of Essential Hypertension: Insights From Studies In Infants Born To Pre-Eclamptic, Hypertensive, And Healthy Mothers.
Professor Isaac Manyonda (St George’s University Hospitals NHS Foundation Trust, London).
Professor Peter Whincup (St George’s, University of London).
Professor Anna-Maria Belli (St George’s University Hospitals NHS Foundation Trust, London).
Dr Donovan Duffy (St George’s University Hospitals NHS Foundation Trust, London).
Professor Duolao Wang (London School of Hygiene & Tropical Medicine, London).
Mr Joseph Onwude (Springfield Hospital, Chelmsford).
Dr Tarek Antonios teaches undergraduates as part of the Medicine MBBS, Medicine MBBS (graduate entry), Biomedical Science courses.
He teaches students from the Foundation School years 1 and 2 and the Pharmacy MPharm (Hons). He also supervises PhD students.