Professor Steve Goodbourn is joint head of the Molecular Cell Biology group within the Biomedical Sciences Research Centre at St George's, University of London.
He is interested in the means by which viruses evade the body’s system of defence against infection and how this impacts on the virus’ host range (what animals they infect) and pathogenicity (the severity of the disease they cause). Type I interferons, which are substances produced by virus-infected cells, comprise the host's primary (innate) line of defence against viruses. They are secreted from the infected cell and induce the expression of a diverse group of genes that create an antiviral state in neighbouring uninfected cells. To establish infections in vivo (inside the body), therefore, viruses must replicate in the face of this powerful defence mechanism.
In collaboration with other groups Professor Goodbourn's group are studying the specifics of evasion strategies used by paramyxoviruses, African Swine Fever Virus, pestiviruses, influenza A virus, and other avian viruses. His group's conclusions demonstrate that viral evasion of innate immunity is a widespread phenomenon and that a variety of distinct mechanisms are employed.
Professor Goodbourn has been at St George’s since 1994. Prior to this he graduated in Biochemistry from the University of Oxford in 1979, where he also gained his DPhil in Clinical Medicine studying under Professor Sir David Weatherall in 1983.
From 1983 to 1987 Professor Goodbourn was a post-doctoral fellow in Professor Tom Maniatis’ group at Harvard University, and from 1987 until 1994 he was the head of the Gene Expression Laboratory at the Imperial Cancer Research Fund (now part of Cancer Research UK) in Lincoln’s Inn Fields, London. He has served in editorial roles on The Biochemical Journal and Trends in Genetics, was a member of the Society for General Microbiology virus group, has served on grant review panels and has given numerous invited lectures.
STAT2 deficiency and susceptibility to viral illness in humans. (2013). Hambleton S, Goodbourn S. Young DF, Dickinson P, Mohamad SMB, Valappil M, McGovern N, Cant AJ, Hackett S, Ghazal P, Morgan NV, Randall RE. Proc. Natl. Acad. Sci. USA, 110, 3053-3058.
Deep sequencing analysis of defective genomes of parainfluenza virus 5 and their role in interferon induction. (2013). Killip, M., Young, D., Gatherer, D., Ross, C., Short, J., Davison, A., Goodbourn, S., and Randall, R. J. J. Virol. 87, 4798-4807.
Genetic screen of a mutant poxvirus library identifies an ankyrin repeat protein involved in blocking induction of avian type I interferon. (2013). Laidlaw S, Robey R, Davies M, Giotis E, Ross C, Buttigieg K, Goodbourn S, Skinner M. J. Virol. 87, 5041–5052.
LGP2 plays a critical role in sensitizing mda-5 to activation by double-stranded RNA. (2013). Childs K, Randall R, Goodbourn S. PLoS ONE 8(5): e64202. doi:10.1371/journal.pone.0064202.
Paramyxovirus V proteins interact with LGP2 to inhibit RIG-I-dependent interferon induction. (2012). Childs K, Randall R, Goodbourn S. J. Virol. 86, 3411-3421.
Viral immune modulators perturb the human molecular network by common and unique strategies. (2012). Pichlmair A, Kandasamy K, Alvisi G, Mulhern O, Sacco R, Habjan M, Binder M, Stefanovic A, Eberle CA, Goncalves A, Bürckstümmer T, Müller AC, Fauster A, Holze C, Lindsten K, Goodbourn S, Kochs G, Weber F, Bartenschlager R, Bowie AG, Bennett KL, Colinge J, Superti-Furga G. Nature, 487, 486-490.
The V proteins of paramyxoviruses bind the IFN-inducible RNA helicase, mda-5, and inhibit its activation of the IFN-beta promoter. (2004). Andrejeva J, Childs KS, Young DF, Carlos TS, Stock N, Goodbourn S, and Randall RE. Proc. Natl. Acad. Sci. USA 101, 17264-17269.
mda-5, but not RIG-I, is a common target for paramyxovirus V proteins. (2007). Childs K, Stock N, Ross C, Andrejeva J, Hilton L, Skinner M, Randall RE, Goodbourn, S. Virology 359, 190-200.
Randall R, Goodbourn S. (2008). Interferons and viruses: an interplay between induction, signalling, antiviral responses and virus countermeasures. J. Gen. Virol. 89, 1-47.
Kay Childs; Interaction of paramyxoviruses with the interferon system
Craig Ross; Interaction of paramyxoviruses with the interferon system
Isabelle Crevel; Interaction of paramyxoviruses with the interferon system
Claire McGuinness; Virus evasion of the interferon system in bats
Matthew Pickin; Regulation of type I IFN production by paramyxoviruses
Josie Golding (IAH supervisor Chris Netherton); Role of interferon-regulated genes in the control African swine fever virus replication.
Beatrix Sanz-Bernardo (IAH supervisor Michael Baron); Comparison of Rinderpest and PPRV immune evasion strategies
Ben Jackson (IAH supervisor Bryan Charleston); Understanding the significance of nuclear localisation of positive strand RNA virus proteins
Claire Barber (IAH supervisor Linda Dixon); Studies on the ASFV DP71L protein
Professor Rick Randall (University of St Andrews)
Dr Michael Skinner (Imperial College London)
Dr Linda Dixon (Institute for Animal Health)
Dr Bryan Charleston (Institute for Animal Health)
Dr John McCauley (National Institute for Medical Research)
Professor Tony Fooks (Veterinary Laboratories Agency)
Dr Paul Duprex (Boston University)
2004-2009, £375,421. “Pestivirus evasion of the intracellular antiviral response to infection”. A three centre collaboration involving Professor Goodbourn (lead applicant), Dr. John McCauley (Institute for Animal Health-Compton) and Dr. Penny Powell (Institute for Animal Health-Pirbright). Funded by the Biotechnology and Biological Sciences Research Council (BBSRC) Viral Diseases of Livestock Initiative
2007-2011, £262,575. “Mechanism of action of an African swine fever virus virulence factor". A two centre collaboration involving Professor Goodbourn and Dr. Linda Dixon (Institute for Animal Health-Pirbright). Funded by the BBSRC.
2009-2014, £721,092. “The interaction of paramyxoviruses with the interferon system”. A two centre collaboration involving Professor Goodbourn and Professor Rick Randall (University of St. Andrew’s). Funded by The Wellcome Trust.
2009–2012, £309,505. “The avian interferon system”. A two centre collaboration involving Professor Goodbourn and Dr Mike Skinner (Imperial College, London). Funded by the BBSRC.
2013–2018, £689,992. “Developing Rapid Responses to Emerging Virus Infections of Poultry”. A multi-centre BBSRC-funded strategic LoLa.