Paul Andrews is Emeritus Professor of Comparative Physiology at St George’s University of London. He studied Physiology at undergraduate and postgraduate levels at the University of Sheffield prior to obtaining lectureships at the University of Edinburgh and St George’s, Hospital Medical School.
His research has focused on the pre-clinical neuropharmacology of vomiting and nausea with particular emphasis on this side effect of anti-cancer chemotherapy and the role of the vagus nerve. He has worked on the sites of the anti-emetic action of 5-HT3 and NK1 receptor antagonists in conjunction with colleagues in industry. Recent work, with Prof Rudd, based in Hong Kong, has focused on the use of telemetry to monitor changes in gut function associated with emesis in the ferret as part of refinement of models.
He has a long standing interest in comparative physiology of the digestive tract and is particularly interested in the differences between rodents and other species limiting their utility as models for human diseases (with Prof Sanger, QMUL).
He gave the 2008 Paget Memorial Lecture of the Research Defence Society on “Translating the 3Rs in complex physiological systems” and the 2009 Sydenham Lecture of the Society of Apothecaries on “A brief history of vomiting: The first 700million years”.
Current work is investigating the potential use of databases (with Dr Percie du Sert, NC3Rs, UK) and non-sentient organisms to identify emetic liability of potential new drugs, with Dr R Williams, of the RHUL. He is also involved in a study to identify the brain areas in humans involved in the sensation of nausea led by Prof Aziz at QMUL.
Stern, R. M., Koch, K. L. and Andrews P. L. R. (2011) Nausea: Mechanisms and Management. Oxford University Presspp425
Sanger, G. J., Holbrook, J. D., & Andrews, P. L. R. (2011, July). The translational value of rodent gastrointestinal functions: a cautionary tale. Trends in Pharmacological Sciences, 32. doi:10.1016/j.tips.2011.03.009
Robery, S., Mukanowa, J., Percie du Sert, N., Andrews, P. L., & Williams, R. S. (2011). Investigating the effect of emetic compounds on chemotaxis in Dictyostelium identifies a non-sentient model for bitter and hot tastant research.. PLoS One, 6(9), e24439. doi:10.1371/journal.pone.0024439
Percie du Sert, N., Holmes, A. M., Wallis, R., & Andrews, P. L. (2012, March). Predicting the emetic liability of novel chemical entities: a comparative study. Br J Pharmacol, 165(6), 1848-1867. doi:10.1111/j.1476-5381.2011.01669.x
Percie du Sert, N., Rudd, J. A., Apfel, C. C., & Andrews, P. L. (2011, March). Cisplatin-induced emesis: systematic review and meta-analysis of the ferret model and the effects of 5-HT3 receptor antagonists. Cancer Chemother Pharmacol, 67(3), 667-686. doi:10.1007/s00280-010-1339-4
Holmes, A. M., Rudd, J. A., Tattersall, F. D., Aziz, Q. and Andrews, P. L. R. (2009) Opportunities for the replacement of animals in the study of nausea and vomiting. Br J Pharmacol, 157, 865-80.
Percie Du Sert, N., Chu, K. M., Wai, M. K., Rudd, J. A. & Anderws, P. L. (2009) Reduced normogastric electrical activity associated with emesis: a telemetric study in ferrets. World J Gastroenterol, 15, 6034-43.
Liu, Y –L., Malik, N. M., Sanger, G. J. and Andrews, P. L. (2006) Ghrelin alleviates cancer chemotherapy-associated dyspepsia in rodents. Cancer Chemother. Pharmacol., 58, 326-333.
Andrews, P. L. R., and Rudd, J. A. (2004). The role of tachykinins and the tachykinin NK1 receptor in nausea and emesis. In P. Holzer (Ed.), Tachykinins, handbook of experimental pharmacology (Vol. 164, pp. 359–440). Berlin: Springer Verlag.
Dr C Horn (University of Pittsburgh Cancer Institute)
Dr N Percie du Sert (NC3Rs, UK)
Professor J Rudd (School of Biomedical Sciences, Chinese University of Hong Kong)
Professor D Sims (Marine Biological Laboratories, Plymouth)
Dr R Williams (Royal Holloway University of London)