Professor Michael Patton is Emeritus consultant clinical geneticist and head of the Human Genetics Research Centre at St George’s.
His research interests include clinical genetics, dysmorphology, gene mapping, genetic isolates, Noonan syndrome and malformation syndrome.
He works as a consultant to the biodiagnostics industry and was Director of the London Genetic Knowledge Park.
Initially Professor Patton's research area was looking at the clinical and genetic aspects of Noonan syndrome and with international collaboration his group identified the first gene for Noonan syndrome (PTPN11). He has been involved in the discovery of ten genes and has worked with colleagues on gene mapping in genetic isolates. He established the Birth Defects intercalated BSc and has supervised six MD/PhD students.
Professor Patton has also been involved in the development of academic consultancy and technology transfer. In recent years as Dean of Enterprise and Innovation he oversaw the spin out of a not for profit company providing books and training for adults with learning difficulties.
Professor Patton was a founding member of the Expert Witness Institute and has practiced widely as an expert in legal aspect to the practice of medicine. In this capacity he appeared for the defence in the trials of Angela Cannings and Trupti Patel, both of whom had been wrongly accused of murder after their children died suddenly in infancy.
He worked with the Department of Health in Oman to establish the Medical Genetics Service for the Sultanate of Oman and has trained several of the staff who are providing the service there.
He was also one of the founders of the Birth Defects Foundation (now Newlife Foundation) and has been the medical director of the charity since its inception. The charity is one of the leading children’s research charities in the UK and has funded over 100 research projects throughout the UK.
Professor Patton was responsible for setting up the South West Thames Regional Genetic Service, which provides clinical and laboratory services for a population of three million in South West London, Surrey and West Sussex. He was administrative head of the NHS service for 17 years.
He has previously worked with the Business Department at the University of Warwick and the DTI on a project looking at Bioscience development in USA and UK. He was also Director of the London IDEAS Genetic Knowledge Park and is Consultant Clinical Geneticist to TDL Genetics.
Professor Patton is a member of the following organisations:
Royal College of Physicians
Royal College of Paediatrics & Child Health
Royal Society of Medicine
Visiting Fellow, Green Templeton College, Oxford
British Society of Human Genetics
American Society of Human Genetics
European Society of Human Genetics
Institute of Directors
Expert Witness Institute
Editorial Board, Irish Medical Journal
Editorial Board, Chinese Journal of General Practice
Tartaglia M, Mehler EL, Goldberg R, Zampino G, Brunner H, Kremer H, van der Burgt I, Crosby A H, Ion A, Jeffery S, Kalidas K, Patton MA, Kucherlapati RS, Gelb B. Mutations in the protein tyrosine phosphatase gene PTPN11 cause Noonan syndrome. Nature Genetics 2001; 29:465-8
Braybook C, Doudney K, Marcano AC, Arnason A, Bjornsson A, Patton MA, Goodfellow PJ, Moore GE, Stanier P. The T box transcription factor gene TBX22 is mutated in X linked cleft palate and ankyloglossia. Nat Genet 2001; 29: 179-83
Simpson MA, Cross H, Proukakis C, Priestman DA, Neville DC, Reinkensmeier G,Wang H, Wiznitzer M, Gurtz K, Verganelaki A, Pryde A, Patton MA, Dwek RA, Butters TD, Platt FM, Crosby AH. Infantile-onset symptomatic epilepsy syndrome caused by a homozygous loss-of-function mutation of GM3 synthase. Nat Genet. 2004;36:1225-9
Cirstea IC, Kutsche K, Dvorsky R, Gremer L, Carta C, Horn D, Roberts AE, Lepri F, Merbitz-Zahradnik T, Konig R, Kratz CP, Pantaleoni F, Dentici ML, Joshi VA, Kucherlapati RS, Mazzanti L, Mundlos S, Patton MA, Silengo MC, Rossi C, Zampino G, Digilio C, Stuppia L, Seemanova E, Pennacchio LA, Gelb BD, Dallapiccola B, Wittinghofer A, Ahmadian MR, Tartaglia M, Zenker M. A restricted spectrum of NRAS mutations causes Noonan syndrome. Nat Genet. (2010) 42:27-9.
Rajab A, Patton MA A study of consanguinity in the Sultanate of Oman. Ann Hum Biol 27:321-6 (2000)
Noonan syndrome – collaboration with Bruce Gelb (Mount Sinai Hospital New York) and Ineke van der Burgdt (Medical Genetics Nijmegen) and the RAS-MAPK international consortium
Oman – collaboration with Anna Rajab and Mazin Al Khabouri at the Royal Hospital Muscat
International teaching courses – with Ken McElrevy Human Reproduction Pasteur Institute, Alan Bittles, Edith Cowen University Australia, Wei Wang Capital Medical School Bejing, and ICRF
Photogrammetry in dysmorphology – Peter Hammond (University College London)
Andrew Crosby – gene mapping in genetic isolates
Anna Rajab and Mazin Al Khabouri – genetic studies in Oman
International collaborators – Noonan syndrome
BDF Newlife (now known as Newlife Foundation)
Guide Dogs for the Blind
Medical Research Council
British Heart Foundation
Special trustees of St George’s Hospital
Ministry of Health, Oman
Department of Health
Department of Trade and Industry