Professor Greenwood is Professor of Vascular Pharmacology at St George's.
His work is concerned with the study of ion channels – transmembrane pores which allow the passage of charged particles (ions) into and out of a cell – that are crucial for controlling cellular activity in the smooth muscle (involuntary muscle) of various tissues including blood vessels, intestines, uterus and bladder.
His research aims to define the role of specific ion channels (listed below) in blood vessel smooth muscle activity under normal physiological circumstances or in disease conditions. His research has been funded by the British Heart Foundation (UK), Medical Research Council (UK), Action Medical Research (UK) as well as the Biotechnology and Biological Sciences Research Council (UK).
Primary research areas
• Characterisation in vascular and visceral smooth muscle cells of the expression, functional role and regulation of potassium channels encoded by KCNQ genes and ether-a-go-go related genes, which are associated with a number of hereditary neuronal and cardiac diseases.
• Characterisation of the molecular, biophysical and regulatory aspects of calcium-gated chloride channels, which underlie contraction of vascular smooth muscle cells.
• Identified expression and a functional role for voltage-gated sodium channels (SCNA genes) – ion channels that open or close in response to electrical stimuli - and hyperpolarisation-activated cation channels (HCN genes) in vascular smooth muscle.
Professor Iain Greenwood joined St George's, University of London in 1993 as a postdoctoral researcher. He has held a variety of academic positions here since then and became Professor of Vascular Pharmacology in August 2013.
He is a visiting Professor in the Department of Biomedical Sciences (Heart and Circulatory Research Section) at the University of Copenhagen, Denmark. This appointment stems from a five-year collaboration with Professor Søren P Olesen looking at mechanisms involved with vascular disease.
Prof Greenwood obtained a First class Honours Degree in Physiology and Pharmacology at the University of Hertfordshire in 1990. He then studied for a PhD at the University of Manchester in the Smooth Muscle Research Group, under the supervision of Professor AH Weston. In 1998, he was awarded a prestigious four-year Wellcome Trust Career Development Fellowship. This enabled him to spend four months working with Professor Normand Leblanc at the Montreal Heart Institute, and one year working with Professor Burt Horowitz in the Department of Physiology and Cell Biology at the University of Nevada Medical School, Reno, USA.
He is an active member of the British Pharmacological Society and was elected Vice President for External Affairs in January 2014. He is also a member of the Physiological Society and the Scandinavian Physiological Society.
He was editor for the British Journal of Pharmacology from 2006 to 2013.
A full list is available on Professor Greenwood's ResearchGate page.
Professor Greenwood also has a Google Scholar Citation list.
1. Povstyan OV, Barrese V, Stott JB, Greenwood IA (2017). Synergistic interplay of Gβγ and phosphatidylinositol 4,5-bisphosphate dictates Kv7.4 channel activity. Pflugers Arch. 2016 Dec 15. [Epub ahead of print] PubMed PMID: 27981364.
2. Carr G, Barrese V, Stott JB, Povstyan OV, Jepps TA, Figueiredo HB, Zheng D, Jamshidi Y, Greenwood IA (2016). MicroRNA-153 targeting of KCNQ4 contributes to vascular dysfunction in hypertension. Cardiovasc Res. 112, 581–589
3. Stott JB, Barrese V, Greenwood IA (2016). Kv7 Channel Activation Underpins EPAC-Dependent Relaxations of Rat Arteries. Arterioscler Thromb Vasc Biol. 2016 Dec;36(12):2404-2411. PubMed PMID: 27789473.
4. Jepps TA, Olesen SP, Greenwood IA & Dalsgaard T (2016). Molecular and functional characterisation of Kv7 channels in penile arteries and corpus cavernosum of healthy and metabolic syndrome rats. British Journal of Pharmacology. 173(9):1478-90
5. Testai L, Barrese V, Soldovieri MV, Ambrosino P, Martelli A, Vinciguerra I, Miceli F, Greenwood I, Curtis MJ, Breschi MC, Sisalli MJ, Scorziello A, Canduela MJ, Grandes P, Calderone V, Taglialatela M. (2016). Expression and function of Kv7.4 channels in Rat cardiac mitochondria: possible targets for cardioprotection. Cardiovascular Research. 110(1):40-50
6. Jepps TA, Carr G, Lundegaard P, Olesen SP, & Greenwood IA (2015). Fundamental role for the KCNE4 ancillary subunit in Kv7.4 regulation of arterial tone. Journal of Physiology, 593(24):5325-40
7. Stott JB, Povsteyan S, Carr G, Barrese V, Greenwood IA (2015). G-protein βγ subunits are positive regulators of Kv7.4 and native vascular Kv7 channel activity. Proceedings of the National Academy of Sciences, 120 (20), 6497-6502.
8. Barrese V, Taglialatela M, Greenwood IA, Davidson CD (2015). Protective role of Kv7 channels in oxygen and glucose deprivation-induced damage in rat caudate nucleus. Journal of Cerebral Blood Flow & Metabolism. 35(10):1593-600.
9.Stott, JB, Jepps TJ, Leighton, E, Barrese V, Greenwood IA (2015). Contribution of Kv7 channels to natriuretic peptide mediated vasodilatation in normal and hypertensive rats. Hypertension, 65(3): 676-82
- Stott JB, Povsteyan S, Carr G, Barrese V, Greenwood IA (2015). G-protein subunits are positive regulators of Kv7.4 and native vascular Kv7 channel activity. Proceedings of the National Academy of Sciences, 120 (20), 6497-6502.
- Pritchard HAT, Leblanc N, Albert AP & Greenwood IA (2014). Inhibitory role of phosphatidylinositol 4,5 bisphosphate in arterial TMEM16A encoded calcium-activated chloride channel gating. Br J Pharmacol 171, 4311-4321.
- Jepps TA, Chadha PS, Davis AJ, Harhun MI, Cockerill GW, Olesen SP, Hansen RS, Greenwood IA. Downregulation of Kv7.4 channel activity in primary and secondary hypertension. Circulation, 2011, 124:602-611.
- Greenwood IA, Yeung SY, Tribe RM, & Ohya S. Loss of functional K+ channels encoded by ether-a-go-go-related genes in mouse myometrium prior to labour onset Journal of Physiology. 2009, 587, 2313-2326.
- Yeung SYM, Pucovský V, Moffatt JD, Saldanha L, Schwake M, Ohya S, Greenwood IA. Molecular expression and pharmacological identification of a role for Kv7 channels in murine vascular reactivity. British Journal of Pharmacology. 2007, 151, 758-770.
Professor Greenwood's research group comprises Dr Jennifer Stott, Dr Vincenzo Barrese, Dr Sasha Povsteyan and a PhD student, Mr Henry Askew-Page.
Professor Greenwood also has a postdoc, Dr Thomas Dalsgaard, at the University of Copenhagen Biomedical Institute.
Professor Greenwood has been collaborating with Professor Normand Leblanc of the Department of Pharmacology at the University of Nevado, Reno, USA, since he worked with him during his Wellcome Trust Career Development Fellowship.
He also has a longstanding collaborative relationship with Professor Susumu Ohya within the Department of Pharmacology at Kyoto Pharmaceutical University, Kyoto, Japan, investigating the expression of KCNQ and ether-a-go-go related genes (KCNH) in vascular and visceral smooth muscles.
His other international collaborators include:
- Dr Michael Schwake, Faculty of Chemistry, University of Bielefeld, Germany (structural aspects of KCNQ channels)
- Professor William Cole, professor in cardiovascular research, physiology and pharmacology, University of Calgary, Canada (regulation of cerebral artery contraction)
- Professor Søren P Olesen, Department of Biomedical Sciences, Heart and Circulatory Research Section Copenhagen, Denmark (vascular effects of Kv7 channels)
- Professor Mark Shapiro, University of San Antonio, TX, US- regulation of TMEM16A encoded chloride channels.
In London, he is collaborating with Dr Rachel Tribe at King's College London (K+ channel activity in the uterus).
Regulation of cardiovascular Kv7 channels by βγ G protein subunits
British Heart Foundation (PG/15/97/31862)
April 2016 -April 2019 £195, 661
Defining the role of phosphatidyl 4, 5 bisphosphate on arterial calcium-activated chloride channels
British Heart Foundation (PG/14/57/30992)
Interplay of Kv7 channels and calcium-gated chloride channels in coronary artery regulation
Novo Nordsk Foundation (Grant number 6553)
Sept 2015-Sept 2017. DKK 1,000,000.
Role of defective Kv7.4 channels in vascular disease
Medical Research Council (MR/K019074/1)
March 2013 to January 2017, £584,050.
Physiological impact of Kv7 channels in cAMP-mediated arterial dilatation
British Heart Foundation (PG/12/63/29824).
October 2012 to September 2015, £185,878.
An investigation into the synthesis of a range of heterocyclic compounds and their evaluation as antihypertensive agents
Awarded to L Tyrrell (Kingston University), I Greenwood (co-supervisor)
South West London Academic Network (SWan) (PhD studentship)
October 2011 to September 2014, £65,000
Kv7 channel: a novel target for the treatment of preterm labour?
Awarded to R Tribe, I Greenwood (co-applicant) and others
Medical Research Council
April 2012 to April 2015, £729,853
Molecular definition of the role of Kv7 channels in the cerebral circulation
British Heart Foundation (PG/09/104).
January 2010 to April 2012, £173,624
Regulation of Kv7 channels in vascular smooth muscle
BBSRC (Biotechnology and Biological Sciences Research Council) four-year CASE (formerly known as Collaborative Awards in Science and Engineering) PhD studentship with NeuroSearch A/S, Denmark
September 2009 to September 2013, £82,410
Contribution of bestrophins to calcium-activated chloride channels in vascular myocytes
British Heart Foundation (PG/07/127/24235).
January 2008 to January 2011, £158,653.
Professor Greenwood is the St George's director for the Pharmacy MPharm (Hons) degree run jointly by Kingston University and St George’s. He teaches cardiovascular pharmacology to pharmacy students.
He also teaches basic and advanced pharmacology to medical students and students on the BSc Biomedical Science course.
He is a responsible examiner for the Biomedical Science BSc (year 1), and he supervises Masters and MRes students.