Dr Elijah Behr is a Reader at St George's, University of London and an Honorary Consultant Cardiologist at St George's University Hospitals NHS Foundation Trust, specialising in cardiac electrophysiology.
Dr Behr's clinical and research interest is in sudden death and its genetic, clinical, epidemiological and pathological investigation. His aim is to develop novel approaches to risk stratification and prevention.
His interests also extend to novel genetic, electrophysiological and structural markers for diagnosis and risk stratification of monogenic cardiac diseases such as the long QT and Brugada syndromes and cardiomyopathies including ARVC. He has also expanded interests in genetic risk of sudden death in sudden infant death syndrome (SIDS), the general population and acquired disease groups utilising large cohort collaborations. The role of early repolarisation in the risk of sudden death in the general population is a particular focus
Dr Behr was appointed in 2007 having undertaken full-time clinical training at St George's. His undergraduate medical education was completed at St John's College, University of Cambridge and Guy's Hospital, London.
This interest first developed at St George's, University of London in 1999 when he studied victims of unexplained sudden death (the Sudden Arrhythmic Death Syndrome [SADS]) and their families. He is considered an international expert in this area and has promoted improvement in patient services and pathways as part of chapter 8 of the National Service Framework. SADS research now focuses on the role for molecular autopsy in diagnostics and novel gene discovery utilising next generation sequencing and associating these with pathological and clinical findings. Drug-induced arrhythmia has also been an important area of interest for epidemiological, electrocardiographic and genetic research.
Raju H, Papadakis M, Govindan M, Bastiaenan R, Chandra N, O'Sullivan A, Baines G, Behr ER. Low Prevalence of Markers of Sudden Cardiac Death in Victims of Brugada Syndrome: Relevance to Risk Stratification. JACC 2011 (in press).
Govindan M, Batchvarov VN, Raju H, Nesan S, Mukhtar B, Bastiaenen R, Kiotsekoglou A, Camm AJ, Behr ER. Utility of high and standard right precordial leads during ajmaline testing for the diagnosis of Brugada syndrome. Heart 2010. doi:10.1136/hrt.2010.201244.
Behr ER, Dalageorgou C, Christiansen M et al. Sudden arrhythmic death syndrome: familial evaluation identifies inheritable heart disease in the majority of families. Eur Heart J 2008;29:1670-80.
Makita N, Behr E, Shimizu W et al. The E1784K mutation in SCN5A is associated with mixed clinical phenotype of type 3 long QT syndrome. J Clin Invest 2008;118:2219-29.
Behr ER, Casey A, Sheppard M et al. Sudden arrhythmic death syndrome: a national survey of sudden unexplained cardiac death. Heart 2007;93:601-5.
Behr E, Wood DA, Wright M et al. Cardiological assessment of first-degree relatives in sudden arrhythmic death syndrome. Lancet 2003;362:1457-9
ECG, echocardiographic and non-invasive markers: Velislav Batchvarov, Anatoli Kiotsekoglou, Abdulrahman Nasseef, Rachel Bastiaenen, Martina Muggenthaler, Hariharan Raju.
Drug-induced arrhythmia: Rachel Bastiaenan, Linda Robinson (with Professors Camm and Jeffery).
Sudden Arrhythmic Death Syndrome: Hariharan Raju (with Professor Sharma).
Paediatric risk and Sudden Infant Death Syndrome: Leonie Wong (Dr Jeffrey and Dr Till).
Long QT syndrome: Martina Muggenthaler (with Professors Crosby and Jeffery and Dr Bevan).
Brugada syndrome and early repolarisation: Rachel Bastianenan (with Dr Jamshidi and Professor Sharma).
Heart failure and ICD therapy: Lilly Mandarano (with Dr Anderson).
Inherited heart diseases and SADS
SGUL: Professor Sanjay Sharma, Professor John Camm, Professor Steve Jeffery, Professor Andrew Crosby, Dr Steve Bevan, Dr Yalda Jamshidi, Dr Nick Bunce, Dr Lisa Anderson.
Royal Brompton Hospital: Professor Stuart Cook, Dr Mary Sheppard, Dr Jan Till, Dr Sanjay Prasad.
Northern Ireland: Dr Pascal McKeown.
Wales: Dr Peter O’Callaghan, Dr Mark Anderson.
Denmark: Dr Michael Christiansen, Dr Jacob Tfelt.
Holland: Professor Arthur Wilde, Dr Connie Bezzina.
Japan: Dr Naomasa Makita.
USA: Professor Dan Roden, Dr Mike Ackerman.
SCN5A E1784K genetic modifier study: PI with Dr Makita.
QRS Consortium – Brugada genetics: co-PI with Dr Jamshidi and Dr Nona Sootodehnia (USA).
Brugada NET project led by Professor Eric Schulz-Bahr (Germany) and Richard Redond (INSERM – France).
QT-IGC consortium led by Dr Arne Pfeufer (Italy) and Dr Chris Newton-Cheh (USA) with Dr Mike Ackerman (USA).
ARITMO EU FP7 group led by Miriam Sturkenboom, Holland
SAEC led by Mr Arthur Holden and Professor Munir Pirmohammed.
Leducq network alliance against SCD led by Professor Dan Roden, Dr Stefan Kaab and Dr Moritz Sinner (Munich).
Dr Arne Pfeufer (Italy), Dr Steve Bevan, Professor Steve Jeffery
Dr David Fitzpatrick (Edinburgh), Dr Peter Fleming (Bristol), Dr Marta Cohen (Sheffield).
Early Repolarisation Consortium: co-PI with Dr Jamshidi
ECG markers: Dr Mark Gallagher
Expertise in arrhythmia, sudden death, ICD indications, inherited heart disease and cardiac genetics.
Human Genome Strategy Group (HGSG) Service Development & Delivery Working Group, ICC Service Development Steering Group.
AICC council member, HRUK ICC guideline expert group for genetic testing and ICD indications, UK Cardiac Pathology Network Steering Group HRUK representative.
Coronial expert witness
British Heart Foundation
2010 Special Project: Next Generation Sequencing in Inherited Heart Disease, Co-applicant: £1,000,000.
2008 Cardiac Genetic Nurse grant: £200,000.
2002 Special Project: Drug Induced Arrhythmia Risk Evaluation (DARE) Study: Co-Applicant £1,700,000.
2009 FP7: ARITMO 3 year award: Co-Applicant Euro 2,700,000.
2010 St George’s Trustees: £5,000.
2009 Cardiac Risk in the Young Research Fellow grant: £87,400.
2009 Serious Adverse Events Consortium: $125,000.
2010 Biotronik unrestricted grant for research into sudden death in the young: £38,000.
2009 Biotronik Research Nurse (Heart failure and Devices): £90,000