Professor Robinson is Professor of Respiratory Cell Science at St George's. He is studying how proteinase enzymes, or enzymes that catalyze the degradation of proteins or polypeptides in water, interact with mucosal (mucus-secreting) surfaces to cause disease.
In particular, growing evidence indicates that enzyme activity of key allergens, such as those from house dust mites, is crucial to the development of allergy. Elucidation of the mechanisms of interactions between environmental allergens and mucosal surfaces has identified and validated new therapeutic targets for the development of novel disease treatments. This work makes full use of robotic high throughput screening and other state-of-the-art techniques in the pursuit of new medicines arising from this research.
Major research achievements include characterization of pulmonary prostaglandin (a group of cyclic fatty acids with hormone-like effects) transport (subsequently identified as the 12TM PGT transporter), identification of steroid-insensitive pathways of arachidonate (an unsaturated fatty acid important to human nutrition) release and, in 1999, the first molecular demonstration of that tight junctions contributed to major human disease.
In 1986, Professor Robinson was recipient of the Pfizer Prize for Experimental Biology, He was an Editor of the British Journal of Pharmacology from 1988-1994 and continues to review for a range of leading publications and other bodies.
He graduated with a BSc from King’s College London and obtained my PhD at the Royal Postgraduate Medical School, London. I am co-founder of the drug discovery company Aldezon and currently Professor of Respiratory Cell Science at SGUL.
Professor Robinson is a member of the following organisations:
American Chemical Society
American Thoracic Society
British Pharmacological Society
International Protease Network