Abhiram Prasad is Professor of Interventional Cardiology at St George's and Honorary Consultant Cardiologist at St George’s University Hospitals NHS Foundation Trust.
Professor Prasad’s research interests are in percutaneous (medical procedure done via needle-puncture of an artery) coronary intervention and coronary artery disease. He has published over 150 peer reviewed publications.
Specific areas of interest include Percutaneous coronary intervention and translational research in coronary atherosclerosis.
Percutaneous coronary intervention
Outcomes research using large single-center and international multicenter (in collaboration with the Cardiovascular Research Foundation) registries. Recent work has contributed significantly in the understanding of the clinical significance of periprocedural myocardial injury during percutaneous revascularisation.
Myocardial perfusion and reperfusion injury in patients undergoing percutaneous revascularization - recent work has included a randomized clinical trial exploring the cardioprotective effects of remote preconditioning during percutaneous coronary intervention. Another study has explored the role of the endothelin system on microvascular blood flow following angioplasty in patients with non-ST elevation myocardial infarction.
Novel intravascular imaging - co-investigator in the Massachusetts General Hospital Optical Coherence Tomography Registry. Also, investigating the utility of imaging intracoronary plaque lipid using near infrared spectroscopy.
Member of Research and Publication Subcommittee of the American College of Cardiology’s Cath PCI NCDR Registry.
Translational research in coronary atherosclerosis
This research has focused on the role of endothelial dysfunction in early atherosclerosis.
Past studies have investigated the impact of acute and chronic effects of angiotensin converting enzyme inhibition, angiotensin receptor blockade, endothelin antoagonism on coronary and peripheral endothelial dysfunction.
Co-investigator on a National institute for Health funded grant exploring the role of Lp-PLA2 in early atherosclerosis in humans.
Apical ballooning syndrome (Takotsubo or stress cardiomyopathy)
Professor Prasad is one of the world’s experts on this unique transient cardiomyopathy that mimics an acute coronary syndrome. He described one of the first case series of such patients in the Western population, and has published extensively on its pathophysiology and clinical features.
Professor Prasad holds the rank of adjunct professor of Medicine at the Mayo Clinic in the United States. He is a Fellow of the Royal College of Physicians, American College of Cardiology, European Society of Cardiology, and the American Heart Association.
Professor Prasad is a graduate of the University of London and trained at the National Institutes of Health and Mayo Clinic in the United States. He is a recipient of the Samuel A. Levine Young Clinical Investigator Award. After completing his cardiology training, he worked as a consultant interventional cardiologist in the Cardiovascular Division of the Mayo Clinic for approximately 10 years.
Prasad A. Slow but Steady Progress Towards Understanding Periprocedural Myocardial Infarction. Eur Heart J 2013; 34:1615-1617.
Prasad A, Dangas G, Srinivasan M, Yu J, Gersh B, Mehran R, Stone G. Incidence and Angiographic Characteristics of Patients With Apical Ballooning Syndrome (Takotsubo/Stress Cardiomyopathy) in the HORIZONS-AMI Trial. Cath Cardiovasc Interv 2013.
Prasad A, Gossel M, Hoyt J, Lennon R, Polk L, Simari R, Holmes D, Rihal C, Lerman A. Remote Ischemic Preconditioning Immediately Before Percutaneous Coronary Intervention Does Not Impact Myocardial Necrosis, Inflammatory Response and Circulating Endothelial Progenitor Cell Counts. Cath Cardiovasc Interv. 2013;81:930-936.
Herrmann J, Lennon RJ, Barsness G, Sandhu G, Gulati R, Best P, Sorajja P, Bresnahan JF, Mathew V, Bell M, Prasad A. High Sensitivity C-Reactive Protein and Outcomes Following Percutaneous Coronary Intervention in Contemporary Practice. Circulation Cardiovasc Interv. 2012;5:783-790.
Summers M, Blauwet, L, Prasad A. Detection of Myocardial Bridging Induced Ischemia During Cardiac Catheterization by Dobutamine Stress ECG Body Surface Mapping. Eur Heart J. 2012;33:514.
Madhavan M, Pislaru S, Prasad A. Dynamic Left Ventricular Outflow Tract Obstruction and Acute Heart Failure in Takotsubo Cardiomyopathy. J Am Coll Cardiol. 2011;58:1196.
Prasad A, Herrmann J. Myocardial Infarction due to Percutaneous Coronary Intervention. N Engl J Med 2011;364: 453-64.
Prasad A, Stone G, Holmes D, Gersh B. Reperfusion Injury, Microvascular Dysfunction and Cardioprotection: The “Dark Side” of Reperfusion. Circulation 2009:120:2105-2112.
Prasad A, Gersh B, Bertrand ME, Lincoff M, Moses JW, Ohman M, White HD, Pocock SJ, McLaurin BT, Cox DA, Lansky AJ, Mehran R, Stone GW. Prognostic Significance of Periprocedural versus Spontaneously Occurring Myocardial Infarction Following Percutaneous Coronary Intervention in Patients with Acute Coronary Syndromes: An Analysis from the ACUITY trial. J Am Coll Cardiol 2009;54:477–86.
Mayo Clinic, United States
Cardiovascular Research Foundation, United States