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2005
- Austen BM and Sidera C. (2005) The Role of Cholesterol in Beta-Amyloid Production in Alzheimer’s Disease (In :Trends in Cholesterol Research, Ed Kramer MA) Nova Science Publishers, ISBN 1-59454-378-X
- Austen, BM., Parsons, R. and Sidera C (2005) The regulation of beta-secretase by cholesterol and statins in Alzheimer's Disease. J Neurological Sciences. 229-230; 269-273.
- Austen BM., Parsons, R. and Sidera, C (2005) Post-translational Processing of beta-Secretase in Alzheimer's Disease. Proteomics. 5, 1533-1543.
- Gibson G, Agnaf, OM, Anwar, Z, Sidera C, Isbister A & Austen BM (2005); Structure and Neurotoxicity of novel amyloids derived from the BRI gene. Biochem Soc Trans.33, 1111-1112
- Parsons RB and Austen BM (2005) Protein lipidation of BACE. Biochem Soc Trans. 33, 1091-1093.
2004
- Sidera
C, Parsons R, Austen B.
Proteolytic cascade in the amyloidogenesis of Alzheimer's disease.
Biochem Soc Trans. 2004 Feb;32(Pt 1):33-6.
- Gibson
G, Gunasekera N, Lee M, Lelyveld V, El-Agnaf OM, Wright A, Austen B.
Oligomerization and neurotoxicity of the amyloid ADan peptide implicated
in familial Danish dementia.
J Neurochem. 2004 Jan;88(2):281-90
- Properties of Neurotoxic Peptides related to the BRI gene
Omar El-Agnaf, Gillian Gibson, Maria Lee, Andrew Wright, and Brian Austen (2004) Protein & Peptide Letters 11; 207-212.
- Gillian Gibson David Allsop and Brian Austen (2004)
Induction of Cellular Oxidative Stress by the beta-Amyloids
Protein & Peptide Letters 11; 257-270
- No Clear-Cut Answers on Statins as Therapy for Alzheimer's Disease, Parsons R and Austen BM; Newsreport
http://www.docguide.com/dg.nsf/PrintPrint/A3B4C1FF17289EEA85256ED600494A8F
http://www.alzheimersupport.com/library/showarticle.cfm/id/2130
2003
- Patel
VB, Chaurand P, Caprioli RM, Austen BM, Frears ER, Manca F, Davies H,
Vrana KE, Wheeler And M, Preedy VR.
Emerging
techniques in biomedical research and their application to alcohol toxicity.
Alcohol Clin Exp Res. 2003 Feb;27(2):348-53
- Austen
BM, Sidera C, Liu A, Frears E.,
The role of intracellular cholesterol on the Processing of the b-amyloid
precursor protein J Nutr Health Aging, 2003 7, 31-36
2002
- Sidera
C; Liu, C and Austen BM.
Pro-domain
removal in ASP-2 and the cleavage of the amyloid precursor are influenced
by pH BMC Biochemistry 2002, 3:25
- B. Austen,
O. El-Agnaf, S. Nagala, B. Patel, N. Gunasekera, M. Lee and V. Lelyveld.
Properties
of neurotoxic peptides related to the BRI gene. Biochem. Soc. Trans
(2002) 30, 557–559,
- Austen
B, Christodoulou G, Terry JE.
Relation
between Cholesterol levels, Statins and Alzheimer s Disease in the human
population.
J Nutr Health Aging. 2002;6(6):377-82.
2001
- Lelyveld
V, El-Agnaf O, Siligardi G, Hussain R, Haris PI, Lee M and Austen B
(2001) Conformational
analysis of peptides derived from the BRI gene. Spectroscopy 15;
129-139
- Easterfield
AJ, Austen BM, Westwood OM.(2001) Inhibition
of antigen transport by expression of infected cell peptide 47 (ICP47)
prevents cell surface expression of HLA in choriocarcinoma cell lines.
Reprod Immunol 2001 50(1):19-40
- El-Agnaf
OMA, Nagala, C, Patel, BP and Austen BM (2001) Non-fibrillar
Oligomeric Species of the Amyloid Abri Peptide, Implicated in Familial
British Dementia are more potent at Inducing Apoptotic CellDeath than
Protofibrils or Mature fibrils J Molecular Biology 310;157-168.
- El-Agnaf
OM, Sheridan JM, Sidera C, Siligardi G, Hussain R, Haris PI, Austen
BM. Effect
of the disulfide bridge and the C-terminal extension on the oligomerization
of the amyloid peptide ABri implicated in Familial British Dementia
(2001) Biochemistry. 2001;40(12):3449-57
Top
2000
- Austen
BM, Frears ER, Davies H. The
use of Seldi Proteinchip arrays to monitor production of Alzheimer's
b-amyloid in transfected cells. J Pept Sci. 2000 6(9):459-6
- Austen
BM (2000) Ciphergen Protein biology system boosts research into Alzheimer;s's
disease. Genetic Engineering News. 20 (2)
- El-Agnaf
OM, Mahil DS, Patel BP, Austen BM. (2000) Oligomerization
and toxicity of b-amyloid-42 implicated in Alzheimer's disease.
Biochem Biophys Res Commun. 273(3):1003-1007.
- El-Agnaf
O, Sheridan J, Goodwin H & Austen BM (2000) Improved
Solid-Phase syntheses of Amyloid Proteins associated with neurodegenerative
Diseases. Peptide and Protein Letters 7; 1-8
- Manca
MF & Austen BM (2000)Proteins
on the Brain. Chemistry in Britain. 36; 29-32
- Sheikh
J, Souberbielle B, Westby M, Austen B, Dalgleish AG.(2000) HIV gp120
plus specific peptides are recognized in a similar manner to specific
HLA plus peptide by HLA-restricted antigen-specific T-cell lines. Viral
Immunol. 2000;13(1):9-17.
- Sian
AK, Frears ER, El-Agnaf, OMA, Patel BP, Manca MF, Siligardi G, Haussain
R and Austen BM (2000) Oligomerisation
of b-Amyloids of the Alzheimer's and the Dutch cerebral Haemorrhage
Types Biochemical J. 349: 299-308.
- G.
Siligardi, R. Hussain, M.F. Manca and B. Austen Conformational changes
in native and HCHWA-D (E22Q) mutant forms of b-amyloid" in Peptides
for the New Millennium (G.B. Fields, J.P. Tam and G. Barany Eds) Kluwer
Academic Publishers (2000) 717-718.
Top
1999
-
Dalgleish AG, Marriott JB, Souberbielle B, Montesano C, Sheikh J, Sidebottom
D, Westby M & Austen BM (1999) The role of HIV gp120 in the disruption
of the immune system. Immunol Lett 66; 81-87.
- Davies
H, Lomas L, Austen B. Profiling of amyloid beta peptide variants using
SELDI Protein Chip arrays. Biotechniques. 1999 27(6):1258-61NB.
- Frears,
ER, El-Agnaf, O, Manca FM, Sian AK, Siligardi S, Hussain R & Austen
BM (1999) Physical and Functional Properties of b-Amyloid Peptide Containing
O-Nitrotyrosine. J Neurosci. in preparation.
- Frears,
ER, Stephens DJ. Walters CE,m Davies H & Austen BM (1999) The
role of cholesterol in the biosynthesis of b-amyloid. NeuroReport
10(8) 1699-1755.
- Sheikh
J, Souberbielle B, Westby M, Austen BM & Dalgleish AG (1999) The gp120
envelope of HIV-1 binds and presents peptides in a similar manner to
human leukocyte antigen. AIDS 13; 1799-1801.
- Sheridan
JM, Hayes, GM & Austen BM (1999) Solid-phase
synthesis and cyclization of a large branched peptide from IgG Fc with
affinity for FcgRI. J Peptide Science. 5 (12) 555-562
- Siligardi
S, Hussain R, Manca FM and Austen BM (1999). Conformational changes
in native and HCHWA-D (Q22E) mutant forms of b-amyloid in "Peptides
for the New Millennium: Proceedings of the 16th American Peptide Symposium,"
edited by Drs. Gregg B. Fields, George Barany, and James P. Tam, Kluwer
Academic Publishers, Dordrecht, The Netherlands.in press
Top
1998
- Austen
BM (1998) Amyloid, cholesterol and Alzheimer's Disease. Research into
the possible effects of diet on the process of the disease. in Dementia
in Focus, Centre for policy on Ageing Reports; No24; p35-45.
- Goodwin
HJ & Austen BM (1998) Synthesis and aggregation of wild-type and E22Q
mutant b-amyloid. Neurobiology of Aging. 19; S46
- Sheridan
JM, Hayes GM & Austen BM (1998) Convergent solid phase synthesis of
Immunoglobulin-like Domains of Macrophage Specific FcgR Receptor (FcgRI)
. Proceedings of the 5th International symposium on Solid Phase Synthesis
& Combinatorial Chemical libraries, London UK, Mayflower UK
- Stephens
DJ & Austen BM (1998) Characterisation
of b-secretase. Biochem Soc Trans 26; 500-504
- Walters
CE & Austen BM (1998) Intracellular cholesterol and b-amyloid as factors
in Alzheimer's disease. Neurobiology of Aging. 19; S49
Top
1997
- Austen,
B.M., Frears, E.R., Stephens D.J. (1997) Characterisation of b-secretase
using antibodies specific to the released N-terminus of b-amyloid. Proc.
of the International Symposium on Solid Phase Syntheisis and Combinatorial
Libraries (ed. R. Epton), Mayflower Publishing, London, UK. Ch 40, 177-181
- Austen
BM & Hayes GM (1997) Uptake of Antibodies by FcgammaR1 presaturated
with huIgG1 on U937 monocyte cell lines. Immunology 92; 52
- Austen
BM, Sheridan J and Hayes GM (1997) MHC Class II Presentation of Peptide
Antigens taken up by macrophage FcgammaR1. Immunology 92; 52
- Easterfield
AJ, Austen BM & Westwood OMR (1997) Fas Ligand expression in chorioncarcinoma
cell lines and inhibition of T-cell proliferation. Immunology 92; 72.
- Hayes
GM, Ndebele P & Austen BM (1997) FcgammaR1 mediated uptake of fluorescent
monomeric peptide-antibody complexes. Immunology 92; 52.
- Ongradi
J, Sheikh JM, Austen BM, Pistello M, Bendinelli M & Dalgleish AG (1997)
Programmed cell death of cultured immune cells induced by HIV-1 or FIV.
Acta Micrbiologica et Immunologica Hungarica 44; 48-49.
- Politopoulou
G, Powell JF, Whatley SA and Austen BM (1997) Expression of the Human
Recombinant Prion Protein (PrPc). Abst Vol 14 of the Brain Research
Association; p60.
- Stephens
DJ, Hayes GM and Austen BM (1997) Intracellular Localisation of the
ß-Secretase Cleavage of Alzheimers's APP. Abst Vol 14 of the Brain Research
Association; p76.
Top
1996
- Li
M-S, Garcia-Asua G, Bhattacharyya U, Mascagni P, Austen BM & Roberts
MM (1996) The
Vpr protein of Human Immunodeficiency Virus Type 1 Binds to nucleocapsid
Protein p7 in vitro. Biochem. Biophys. Res. Commun. 218; 352-355
- Patel
S & Austen BM (1996) Substitution
of fifty four homologue (Ffh) in E. coli with mammalian 54-kDa protein
of signal recognition particle. European J Biochem. 238; 760-768
- Patel
S & Austen BM (1996)
Expression and purification of the 54 kDa subunit of signal recognition
particle from E. coli. J Protein Expression and Purification. 8;
283-294
- Stephens
DJ, Hayes GM and Austen BM (1996) Intracellular Processing of the Alzheimer's
ß-Amyloid Precursor Protein. In "Function and Dysfunction of the Nervous
System". Abstracts of the LXI Cold Spring Harbor Symposium on Quantitative
Biology. p148
- Stephens
DJ and Austen BM (1996) Metabolites
of the ß-amyloid precursor protein generated by ß-secretase localise
in the trans-Golgi network and late endosome. J Neuroscience Research.
45; 211-225.
Top
1995
- Austen
BM & Hayes GM (1995)
Prediction of the three-dimensional structure of the high-affinity Ig
domain of FcgRI. Biochem. Soc. Trans. 23; 472S
- Austen
BM & Stephens DJ. (1995) Cleavage
of a ß-amyloid precursor sequence by cathepsin D. Biomedical Peptides,
Proteins & Nucleic Acids. Vol 1; Number 4; 243-246.
- Austen,
BM & Kulkarni S (1995) The Biosynthesis of Membrane Proteins, in "A
Multi-Volume Treatise on Biomembranes; General Principles" (ed Dr A.G.Lee)
JAI Press, Greenwich, Connecticut; London, England p107-135.
- Austen,
B.M. & Stephens, D (1995) "Protein Targeting" Molecular Biology and
Biotechnology; a Comprehensive Desk Reference (ed R.A.Meyers) VCH Publishers
Inc. New York, Weinheim, Cambridge.pp 774-778.
- Kaderbhai
MA, Harding VJ, Karim A, Austen BM & Kaderbhai, M.A.
Isolation of sheep pancreatic microsomes active in the processing of
newly-synthesised secretory proteins. Biochemical J. (1995) 306,
57-61
- Patel
S & Austen BM (1995) Sequence of the highly-conserved human 54kDa subunit
of signal recognition particle. DNA Sequence. 6(3);167-170. Accession
number X86373
- Patel
S & Austen BM (1994) The structure of the signal-binding domain of the
54kDa subunit of signal recognition particle and its role in membrane
insertion. Biochem Soc Trans. 22; 1030-1033
- Roberts
MM, Garcia-Asua G, Austen BM, Siligardi G, Banfield B, Drake, AF, Wilderspin
AF, Zioh M, Jones I, Bhattacharyya U & Mascagni P. (1995) The structure
of HIV P6 and its importance for Biological Activity. Abstracts of the
14th American peptide Symposium. P261
- Sheikh
J, Ongradi J, Austen BM & Dalgleish A (1995) The
GP120 envelope of HIV binds peptides in a similar manner to human leukocyte
antigens. AIDS; 9; 1799-801.
- Sheikh
J, Ongradi J, Austen BM & Dalgleish A (1995) The GP120 envelope of HIV-1
binds peptides in a similar manner to human leukocyte antigens. AIDS;
9; 1229-1235.
- Stephens
DJ & Austen BM (1995) ß-Amyloidogenic APP fragments accumulate in the
trans-Golgi network and/or late endosome in 293 cells. Alzheimer's Research.
1; Suppl 1; 65.
- Stephens
DJ (1995) Editorial - Apolipoprotein E and Alzheimer's Disease. J. Royal
Soc Health 115, 4
- Stephens
D, Kulkarni S & Austen BM (1995) The Biosynthesis of membrane Proteins.
Biomembranes (ed AG Lee). Volume 1, pages 107-135. JAI Press Inc., London,
England and Greenwich, Connecticut. Soltys AJ, Westwood OMR
Top
1994
- Austen
BM, Bond A & Hay FC (1994) Analysis of rheumatoid factor binding to
synthetic peptides and galactose-deficient molecules. Clin. Exp.
- Austen,
B.M. & Stephens, D (1994) "Protein Targeting" in Encyclopaedia of Molecular
Biology and Biotechnology (ed R.A.Meyers) VCH. New York, Basel, Cambridge.pp
774-778.
- Austen,
B.M., Kulkarni, S. (1994) The Biosynthesis of Membrane Proteins, in
"A Multi-Volume Treatise on Biomembranes; General Principles" (ed Dr
A.G.Lee) JAI Press, Greenwich, Connecticut; London, England p107-135.
- Austen,
B.M., Stephens, D. & Kulkarni, S. (1994) Assembly of Membrane Proteins
and their Movement to the Cell Surface in "Animal Cell Biotechnology
Vol 6 (ed Spier RE & Griffiths JB). Academic Press (London),pp24-47.
- Austen,
B.M. & Hawkes, J. (1994) Side reactions in the Synthesis of Phosphoserine
containing Peptides, in "Innovation and Perspectives in Solid Phase
Synthesis and Complementary Technologies - Biological and Biochemical
Applications - 1994 (ed R Epton) Mayflower Worldwide. Ch 68, pp 437-439.
- He,
M., Liu, W and Austen, BM (1994) Export and expression of Fusion Proteins
in E. coli directed by C-terminally located prepromelittin. DNA & Cell
Biology. 13; 875-882
-
Kaderbhai MA, Harding VJ, Karim A, Austen BM & Kaderbhai, M.A. Isolation
of sheep pancreatic microsomes active in the processing of newly-synthesised
secretory proteins. Biochemical J. (1995) 306, 57-61
- Kulkarni,
S. & Austen, B.M. (1994) The Synthesis and Interactions with Membranes
of Prepromelittin and Promelittin, in "Innovation and Perspectives in
Solid Phase Synthesis and Complementary Technologies - Biological and
Biochemical Applications (ed R Epton) Mayflower Worldwide. Ch 104, 575-578.
- MacLachlan,
LK, Reid, D.G., White, J., Haris, PI., Chapman, D., Lucy, JA. and Austen,
BM. (1994) A
Spectroscopic Study of the Mitochondrial Transit Peptide of Rat Malate
Dehydrogenase. Biochem. J.303; 657-662.
- Rheum
Westwood OMR, Soltys A, Austen BM & Hay FC (1994) Molecular modelling
of IgG Fc reveals clustering of linear sequences to form potential conformational
epitopes for binding rheumatoid factors. Clin. Exp. Rheum.
Top
1993
- Austen,
B.M. (1993) Protein Translocation across Membranes. "The Encyclopedia
of Molecular Biology" (ed Sir John Kendrew, FRS) Blackwell Scientific
Publishers, Oxford.
- He,
M., Jin, L & Austen, BM (1993) The Specificity of Factor Xa in the Cleavage
of Fusion Proteins. J Protein Chemistry 12, 1, 1-5.
- Kulkarni,
S He, M & Austen, B.M. (1993) Translocation
of prepromelittin across the endoplasmic reticulum membrane. Biochem.
Soc. Trans. 21, 311S
- Robinson,
A., He, M., Westwood, OMR, Austen, BM.(1993), Changes
in levels of Pancreatic Endoplasmic Reticulum Proteins that function
in the Translocation and Maturation of Secretory Proteins in response
to cholecystokinin. Cytotechnology. 11, 197-204
Top
1992
- Alder,
G.M., Austen, B.M., Bashford, C.L., Mehlert, A. & Pasternak, C.A. (1991)
Heat Shock Proteins induce Pores in Membranes. Bioscience Reports. 10,
509-517.
- He,
M., Liu, W., Wang, Y & Austen, BM (1992) Optimised Centrifugation for
Rapid Elution of DNA from Agarose Gels. Genetic Analysis Techniques
and Application. 9, 31-33.
- Robinson
A, He M, Westwood OMR & Austen BM (1992) Regulation of Endoplasmic Reticulum
Proteins Functional in the Translocation and Maturation of Secretory
Proteins. In "Baculovirus and Recombinant Protein Production Processes"
(Eds Vlak JM, Schlager E.-J & Bernard AR) Editones Roche, Basel, Switzerland
pp128-144.
- Tizard
MLV, Moss MT, Sanderson JD, Austen BM & Hermon-Taylor J (1992) P43,
The protein product of the atypical insertion element IS900 is expressed
in Mycobacterium paratuberculosis. J Gen Microbiol 138, 1729-1736.
- Westwood,
OMR & Austen, BM (1992) Cross-linking signal sequences to components
of yeast microsomes. In "Protein Synthesis and Targeting in Yeast" (eds
Brown, AJ., McCarthy, JEG, & Tuite, MF) NATO-ASI Seies, Springer-Verlag.pp
315-324.
Top
1991
- Austen,
BM. & Westwood, OMR. (1991) Protein Targeting & Secretion. "In Focus
series" (ed D.Rickwood), IRL Press, OUP, Oxford, New York, Tokyo.
- He,
M., Robinson, A., Adcock, I., Westwood, O. & Austen, B. (1991) Mechanisms
of intracellular targeting and translocation across membranes of newly-synthesized
proteins. Methodological Surveys in Biochemistry and Analysis (eds Reid
E, Cook GMW & Luzio J) 21, 397-406
- He,
M., Adcock, I, Lucy, JA, Chapman, D & Austen, BM (1991) Expression of
honey-bee pre-promelittin as a fused protein in E. coli. J Protein Expression
and Purification. 2, 363-371
-
He, M., Kaderbhai, M.A., Adcock, I. & Austen, B.M. (1991)
An improved and rapid procedure for isolating RNAse-free Escherichia
plasmid DNA. Genetic Analysis Techniques and Applications. 8, 107-110.
- Shorrock,
K., Austen, B.M. & Hermon-Taylor, J (1991) Hyperstimulation
pancreatitis in mice induced by cholecystokinin octapeptide, caerulein,
and novel analogues: effects of molecular structure on potency.
Pancreas 6, 404-406
Top
1990
- Gudgeon,A.M.,
Heath,D.J., Hurley,P., Jehanli,A., Patel,G., Wilson,C., Shenkin,A.,
Austen,B.M., Imrie,C.W., Hermon-Taylor, J. (1990) Trypsinogen
Activation Peptide assay in the early prediction of acute pancreatitis.
Lancet 335, 4-8.
- Robinson,
A., Westwood, O.M.R. & Austen, B.M. (1990)
Interaction of signal peptides with signal recognition particle.
Biochem. J. 266, 149-156.
- Westwood,
OMR & Austen, BM (1990). Signal peptides block processing of alpha-mating
factor in yeast by binding to a microsomal 52kDa protein. J. Cell Biochem
14C, 27
Top
1989
- Adcock,
I., Westwood, O. & Austen, B.M. (1989) Interactions of signal and transit
peptides with membrane proteins and phospholipids. Biochem. Soc. Trans.
17, 823-827.
- Huddy,
S.P., Patel, G., Heywood, G., Austen, B.M. & Hermon- Taylor, J. (1989)
Synthesis of novel tight-binding semi- synthetic inhibitors of pepstatin.
Biochem. Soc. Trans. 17, 1124-5.
Top
1988
- Austen,
B.M. (1988) Peptide Synthesis. in 'Methods in Molecular Biology'. Chapter
22; pp311-331 (ed. J. Walker), Humana Press, Clifton, New Jersey.
- Austen,
B.M. (1988) Peptide Synthesis in T-Bags. in 'Methods in Molecular Biology'
Chapter 23; pp333-340. (ed. J.Walker), Humana Press, Clifton, New Jersey.
- Gudgeon,A.M.,
Jehanli,A., Patel,G., Hurley,P., Austen,B.M., & Hermon-Taylor,J.(1988)
Immunoassay
for free phospholipase A2 activation peptides (PLAP) reporting phospholipase
activation. Pancreas. 3, 599.
- Huddy,
S.P.J., Patel, G., Heywood, G.C., Austen, B.M. & Hermon-Taylor, J. (1988)
The
prevention of acute erosions produced in controlled hypotension/luminal
20% ethanol in rat models by a range of novel semi-synthetic amphiphilic
analogues of pepstatin. Gut, 29, 1569-1577.
- Hurley,
P.R., Cook, A., Austen, B.M. & Hermon-Taylor,J. (1988) Development
of radioimmunoassay for free tetra-L-aspartyl- L-lysine trypsinogen
activation peptides. J. Immunol. Methods 111, 195-203.
- Kaderbhai,M.A.,
Pickering,T., Austen,B.M. & Kaderbhai,N. (1988) A photoreactive Synthetic
Transit Peptide labels 30kDa and 52kDa polypeptides of the chloroplast
inner membrane. Febs. Lett. 232, 313-316.
- Malik,
Z., Bottomley, R. & Austen, B.M. (1988) Allergenic properties of the
Genetic Variants A & B of Bovine beta- lactoglobulin. Int. Arch. Allergy
& App. Immunol. 86, 245- 248
- Malik,
Z. Bottomley, R. & Austen, B.M. (1988) Allergenicity of the major genetic
variants of bovine lactoglobulin. Biochem. Soc. Trans. 16, 338-340.
- Meredith,
C. & Austen, B.M. (1988) Glycoproteins of the rough endoplasmic reticulum.
Biochem. Soc. Trans. 17, 107-108.
Top
1987
- Fidelio,
G.D., Austen, B.M., Chapman, D. & Lucy, J.A. (1987) Interactions
of ovalbumin and its putative signal sequence with phospholipid monolayers;
possible importance of differing lateral stabilities in protein translocation.
Biochem. J. 244, 295-301.
- Meredith
C. & Austen, B.M. (1987) Antibody Probes to the Signal Sequence of Ovalbumin.
Biochem. Soc. Trans. 16, 36-7.
-
Robinson, A. & Austen, B.M. (1987) GTP-Dependant ADP-Ribosylation of
a 22kDa protein in the Endoplasmic Reticulum membrane. FEBS Lett. 218,
63-67.
- Robinson,
A. & Austen, B.M. (1987) The Role of Topogenic Sequences in the Movement
of Proteins through Membranes. Biochem. J. (Review) 246, 249-261.
- Robinson,
A., Kaderbhai, M.A. and Austen, B.M. (1987) Identification
of Signal Sequence binding proteins integrated into the Rough Endoplasmic
Reticulum membrane. Biochem. J. 242, 767-777.
Top
1986
-
Fidelio, G.D., Austen, B.M., Chapman, D. & Lucy, J.A. (1986) Properties
of signal-sequence peptides at an ait-water interface. Biochem.J.
238, 301-304.
- Harris,
PJ, Fidelio, GD, Austen, BM., Lucy, JA & Chapman, D (1987). Secondary
Structure of Signal Sequence Peptides in the presence and absence of
lipid: a Fourier transform infrared spectroscopic investigation. Biochem
Soc Trans. 15, 1129-1131
- Robinson,A.,
Meredith, C., & Austen, B.M. (1986) Isolation
and properties of the signal region from ovalbumin. FEBS Lett. 203,
243-246.
Top
1985
- Cliffe,
S.G.R., Austen, B.M., Hermon-Taylor,J., Hawkes, G. & Grant, D.A.W. (1985)
Use of 13C-NMR for the determination of linkages in acidic peptides.
Int. J. Peptide Protein Res, 25, 663-672.
-
Ford,T.F., Grant,D.A.W. Austen, B.M. & Hermon-Taylor,J. (1985) Intramucosal
activation of pepsinogen in the pathogenesis of acute gastric erosions
in the rat and prevention by the potent semisynthetic amphiphilic inhibitor
pepstatinyl-Gly-Gly-Lys. Clin. Chim. Acta. 145, 35-47.
-
Kaderbhai, M.A. & Austen, B.M. (1985)
Studies on the formation of intrachain disulphide bonds in newly-biosynthesised
bovine prolactin; role of protein disulphide isomerase. Eur.J.Biochem.
153, 167-178.
Top
1984
- Austen,
B.M., Hermon-Taylor, J., Kaderbhai, M.A. & Ridd, D.H. (1984) Design
and synthesis of a consensus signal sequence that inhibits protein translocation
into rough microsomal vesicles. Biochem. J. 224, 317-325.
- Kaderbhai,
M.A. & Austen, B.M. (1984) Dog
pancreatic microsomal membrane polypeptides analysed by two-dimensional
gel electrophoresis. Biochem J. 217, 145-157.
Top
1983
- Austen,B.M.
Lorenz, R., Spitz, M. & Thorpe, R. (1983) Elucidation
of the antigenic determinant in lipotropin for two monoclonal antibodies.
Biochem. Biophys. Res. Commun. 116, 527-533.
- Cliffe,
S, Austen BM & Grant, D (1983) The selective inhibition of enterokinase
by synthetic peptide aldehydes based on the activation peptide of trypsinogen.
In 'Peptides: Structure and Function. (Eds Hruby, V.J. & Rich, D.H.)
Pierce, Illinois, 611-614.
- Thorpe,
R., Spitz,L., Spitz, M. & Austen, B.M. (1983) Detection
and affinity purification of beta-endorphin precursors using a monoclonal
antibody. FEBS. Lett. 151, 105-110.
Top
1982
-
Austen, B.M., Ford, T.F., Grant, D.A.W. & Hermon-Taylor, J. (1982) Solid
phase synthesis of a soluble pepstatin derivative suitable for therapeutic
use. Bioscience Reports. 2, 427-432.
Top
1981
- Austen,
B.M. (1981) Isolation from pituitary granules and properties of a protease
specific for consecutive basic residues. In' Peptides - Synthesis-Structure-Function'
(eds Rich,D.H. & Gross, E) 493-496.
Top
1980
- Austen,
B.M., Haberland, M.E. & Smith, E.L. (1980)
Secondary structure predictions for the NAD-specific glutamate dehydrogenase
of Neurospora crassa. J. Biol. Chem. 255, 8001-8004.
Top
1979
- Austen,B.M.,
Evans, C.J. & Smyth, D.G. (1979) Susceptibility
of neuroactive peptides to aminopeptidase digestion is related to molecular
size. Biochem. Biophys. Res. Commun. 91, 1211- 1217.
- Austen,
B.M. (1979) Predicted
secondary structure of amino-terminal extension sequences of secreted
proteins. FEBS. Lett 103, 308-313.
Top
1977
- Austen,
B.M., Smyth, D.G. & Snell, C.R. (1977) Gamma-endorphin,
alpha-endorphin and methionine enkephalin are formed extracellularly
from lipotropin C-fragment. Nature. 267, 619-621.
- Austen,
B.M. & Smyth, D.G. (1977) Specific
cleavage of lipotropin C-fragment by endopeptidases; evidence for a
preferred conformation. Biochem. Biophys. Res. Commun. 77, 86-94.
- Austen,
B.M. & Smyth, D.G. (1977) The amino-terminus of lipotropin C-fragment
is resistant to the action of aminopeptidases. Biochem. Biophys. Res.
Commun. 76, 477-482. Austen, B.M. & Marshall,R.D. (1977) Acid-base dissociation
constants of glycopeptides. Biochem J. 163, 31-38.
- Austen,
B.M., Nyc, J.F., Brown, D.M. & Smith, E.L. (1977) Nicotinamide
adenine dinucleotide-specific glutamate dehydrogenase of Neurospora.
VIII. Isolation and sequences of peptides from a tryptic hydrolysate
of the maleylated protein. J. Biol. Che,. 252, 8182-8195.
- Austen,
B.M. & Smith, E.L. (1977)
Nicotinamide adenine dinucleotide-specific glutamate dehydrogenase of
Neurospora. VII Isolation and sequences of three large cyanogen bromide
peptides. J. Biol. Chem. 252, 8174-8181.
- Austen
BM, Nyc JF, Smith EL. (1977) Nicotinamide
adenine dinucleotide-specific glutamate dehydrogenase of Neurospora.
VI. Isolation and sequences of eighteen fragments from the cyanogen
bromide digest. J Biol Chem 1977 Nov 25;252(22):8160-73
- Austen,
B.M., Haberland, M.E., Nyc, J.F. & Smith, E.L. (1977) Nicotinamide
adenine dinucleotide-specific glutamate dehydrogenase of Neurospora.
IV. The carboxy-terminal 669 residues of the peptide chain; comparison
with other glutamate dehydrogenases. J. Biol. Chem. 252, 8142-8159.
Top
1976
- Austen,
B.M. & Smith E.L. (1976) Identification
of a functional arginine residue involved in coenzyme binding by the
NAD-specific dehydrogenase of Neurospora. J. Biol. Chem. 251, 5835-5837.
- Austen,
B.M. & Smith, E.L. (1976) Specificity of the extracellular protease
from Staphylococcal aureus. Biochem. Biophys. Res. Commun. 72, 411-417.
Top
1975
- Austen,
B.M., Nyc, J.F. Degani, Y., & Smith, E.L. (1975) Partial
amino acid sequence of NAD-specific glutamate dehydrogenase of Neurospora.
Proc. Natl. Acad. Sci.. USA 72, 4891-4.
- Smith,
E.L., Austen, B.M., Blumenthal, K.M. & Nyc, J.F. (1975) Glutamate dehydrogenases.
In 'The Enzymes' ed Boyer, P.D.) 3rd edition, vol XI. Academic Press,
N.Y., 293-367.
Top
1970
-
Austen, B.M. & Marshall, R.D. (1970) Optical
rotatory dispersion of -N-b-L-aspartyl-2-acetamido-2-deoxy-b-D-glucosamine.
Biochem. Biophys. Acta. 215, 559-561.
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