Aim
Better methods are required to identify high risk patients with asymptomatic carotid stenosis who may be suitable for endarterectomy. Previous small studies have suggested that the presence of asymptomatic embolic signals detected using transcranial Doppler ultrasound may identify a high risk group. ACES is a large multicentre international prospective study which will determine whether asymptomatic emboli detected in the middle cerebral artery are an independent predictor of stroke and TIA risk in patients with asymptomatic carotid stenosis (>70%).
Recruitment
Recruitment is now complete. 484 subjects were recruited with asymptomatic carotid stenosis. Follow-p is ongoing and is scheduled to end by September 2009.
Participating centres, study personnel and number of patients recruited
Centre | Investigators | Recruitment |
00 St George's Hospital (UK) | Prof. Hugh Markus | 71 |
Alice King (current) | ||
Jenifer Siegel (‘07-’08) | ||
Sheila Reihill (‘03-’07) | ||
Marisa Cullinane (‘99-’03) | ||
Helen McCorie, Emma Morgan, Sun Kwon, Raffi Topakian, Kelly Jones & Ruth Keating | ||
01 Kings College Hospital (UK) | Mr Paul Baskerville | 31 |
Dr Colin Deane | ||
Dr David Goss | ||
02 University of Munster (Germany) | Prof. Dr. E. Bernd Ringelstein | 19 |
Dr. Martin Ritter | ||
Ralf Dittrich | ||
Achim Allroggen | ||
03 Leicester Royal Infirmary (UK) | Mr. Ross Naylor | 23 |
Jo Walker | ||
04 Charing Cross Hospital (UK) | Mr. Alun Davies | 6 |
05 University of Dusseldorf (Germany) | Dr. Mario Siebler | 8 |
Dr. Holger Schade | ||
Dr. Torge Brosig | ||
06 Tel Aviv Sourasky Medical Centre (Israel) | Prof. Natan Bornstein | 46 |
Dr. Alex Gur | ||
Sigal Lorenz | ||
08 JW Goethe University Frankfurt (Germany) | Dr. Matthias Sitzer | 14 |
Oliver Singer | ||
10 J. Connolly Memorial Hospital Dublin (Ireland) | Dr. Dermot Fitzgerald | 8 |
Nuala McMahon | ||
11 Martini Ziekenhuis Groningen (The Netherlands) | Dr. Arjen Schaafsma | 84 |
An Fokkens | ||
12 South Manchester University Hospital (UK) | Prof. Charles McCollum | 26 |
Sarah Welsh | ||
Zoe Bonner | ||
13 UCLA School of Medicine (USA) | Dr. Jeffrey Saver | 5 |
Dr. Gina Paek | ||
14 University Hospital Zagreb (Croatia) | Dr. Vida Demarin | 12 |
Dr. Vlasta Vukovic | ||
15 Prince of Wales Hospital (Hong Kong) | Dr. Lawrence Wong | 3 |
Dr. Sunny Qing Hao | ||
Roxanna Liu | ||
16 San Martino Hospital Genova (Italy) | Dr. Gian Andrea Ottonello | 21 |
Dr. Giulia Brusa | ||
Dr. Vittorio Montano | ||
17 University Medical Centre Ljubjana (Slovenia) | Ass. Prof. Bojana Zvan | 4 |
Dr. Janja Pretnar | ||
19 Vilnius University Hospital (Lithuania) | Dr. Dalius Jatuzis | 19 |
20 Singapore General Hospital (Singapore) | Dr. Hui Meng Chang | 15 |
Moi Pin Lee | ||
Meng Cheong Wong | ||
Christopher Chen | ||
22 Institute of Neurology, Queens Square (UK) | Martin Brown | 1 |
23 Bretonneau Hospital Tours (France) | Dr. Francois Tranquart | 2 |
Dr. Aurore Bleuzen | ||
25 Uni. Hospital Josep Trueta Girona (Spain) | Dr. Joaquin Serena | 19 |
Xavier Ustrell | ||
26 State Medical Academy Tbilisi (Georgia) | Dr. Marina Alpaidze | 12 |
Dr. Nana Metreveli | ||
28 Rabin Medical Centre Petach Tikva (Israel) | Dr. Jonathan Streifler | 7 |
Dr. Tilda Sabah | ||
29 Institute of Psychiatry Warsaw (Poland) | Prof. Anna Czlonkowska | 5 |
Dr. Anna Rozenfeld | ||
Dr. Anna Piorkowska | ||
Dr. Marta Skowronska | ||
30 Harbin Medical University (China) | Prof. Song-Bin Qu | 20 |
31 Wagner-Jauregg Hospital Linz (Austria) | Prof. Franz Aichner | 1 |
Dr. Stefan Guggenberger | ||
Total | 482 |
Study statistician: Martin Shipley, University College , London, UK.
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