Paul Heath

Name: Professor Paul Heath

Position: Professor in Paediatric Infectious Diseases

Clinical role: Honorary Consultant in Paediatric Infectious Diseases

Research institute: Institute of Infection and Immunity

Tel: 020 8725 5980

Email: This email address is being protected from spambots. You need JavaScript enabled to view it.

Research

Paul Heath is Professor of Paediatric Infectious Diseases at St George's. He co-leads the Paediatric Infectious Disease Research Group and is director of the Vaccine Institute.

His particular research interests are in the epidemiology of vaccine-preventable diseases, in clinical vaccine trials, particularly in at-risk groups, and in perinatal infections. He coordinates a national neonatal infection network called neonIN which collects data on pathogens causing neonatal infections and aims to focus appropriate treatments and prevention strategies.

Professor Heath’s research concentrates on all aspects of perinatal and neonatal infection. Neonates, particularly when premature, are at high-risk of infections, indeed their risk is higher than at any other age in life. Their immune system is immature rendering them immunocompromised hosts. Infections can be transmitted by the mother in utero, during delivery and breastfeeding (vertical transmission), or from the environment after delivery (horizontal transmission). The most frequent cause of serious bacterial infection in the first three months of life is Group B streptococcus (GBS) and this has been a major focus of Prof Heath`s work, having initially described the burden of disease in the UK in 2000/1 and more recently globally.
 
Defining the epidemiology of all neonatal infections has been an important aspect of his ongoing work with the aim of formulating research priorities and this has been facilitated through the establishment  neonIN as well as through separate specific national surveillance studies on neonatal meningitis (completed in 2012) and on GBS (to begin in early 2014). Prevention of GBS infection has become a major priority but current antibiotic-based strategies are poorly applied and it seems most likely that a vaccine approach will be critical. Pregnancy is increasingly the platform for new vaccines such as GBS and a pipeline of maternal vaccine studies are now envisaged within the group, beginning with a pertussis vaccine trial in 2014 and GBS vaccine trials in 2015.

Management of established neonatal infections is potentially difficult because of growing antimicrobial resistance, again of vital importance to monitor through longitudinal surveillance systems (neonIN) as well as through collaboration with other national databases. Knowledge of the pharmacokinetics and pharmacodynamics of new, or even old antimicrobials, for the treatment of these infections in neonates is poor and this has been an important area for the research group, including coordinating trials such as on the use of meropenem in neonatal meningitis (neomero2 ) and the monitoring of gentamicin and vancomycin in neonatal infections (neoGent and neoVanc). The group additionally has a longstanding interest in clinical trials of new or modified vaccines, especially in at-risk groups, for example studies on the immunogenicity of pandemic H1N1 influenza vaccine in children with cancer, as well as studies in healthy children, for example as part of a large multi-centre trial to assess new influenza vaccines.

Biography

Professor Heath trained in paediatrics and infectious diseases at the Royal Children’s Hospital in Melbourne, the John Radcliffe Hospital in Oxford, and St George’s University Hospitals NHS Foundation Trust.

He is a Fellow of the Royal Australasian College of Physicians and the Royal College of Paediatrics and Child Health. He is also a member of Public Health England Vaccine Preventable Invasive Bacterial Forum, the steering committee of the Brighton Collaboration, the Paediatric European Network for Treatment of AIDS vaccination guidelines group, the advisory committee of the Meningitis Research Foundation and the European Society of Paediatric Infectious Diseases Committee for Research. In addition, Professor Heath is the co-director of the London & South East Medicine for Children Research Network and Secretary of the UK Paediatric Vaccines Group.

Professor Heath is a section editor for Current Opinions in Infectious Diseases (foetal and neonatal infections) and for the Royal College of Paediatrics and Child Health Manual of Infections (Blue Book). He has been invited to give lectures in numerous national and international institutions and meetings.

Professor Heath sits on a number of national committees:

  • Royal College of Paediatrics and Child Health Vaccination of the Immunocompromised Child Guidelines Committee
  • Department of Health Joint Committee on Vaccination and Immunisation (pneumococcal subgroup)
  • The Royal College of Obstetricians & Gynaecologist: Group B Streptococcal Prevention Guidelines Committee

Publications

Recent publications

Cunnington M, Kortsalioudaki C, Heath P. Genitourinary pathogens and preterm birth. Curr Opin Infect Dis. 2013 Jun;26(3):219-30.

Okike IO, Lamont RF, Heath PT. Do we really need to worry about Listeria in newborn infants? Pediatr Infect Dis J. 2013 Apr;32(4):405-6.

Khatami A, Snape MD, Ohene-Kena B, Young K, Oeser C, Michaelis LJ, Macleod E, Smee H, Van Der Meeren O, Leyssen M, Caubet M, Yu LM, Heath PT, Faust SN, Finn A, Pollard AJ. Phase II Study of a Three-Dose Primary Vaccination Course of DTPa-IPV/Hib-MenC-TT Followed by a 12-Month Hib-MenC-TT Booster in Healthy Infants. Pediatr Infect Dis J. 2013 Jan 23.

Oeser C, Lamagni T, Heath PT, Sharland M, Ladhani S. The epidemiology of neonatal and pediatric candidemia in England and Wales, 2000-2009. Pediatr Infect Dis J. 2013 Jan;32(1):23-6.

Blackburn RM, Muller-Pebody B, Planche T, Johnson A, Hopkins S, Sharland M, Kennea N, Heath PT. Neonatal sepsis - many blood samples, few positive cultures: implications for improving antibiotic prescribing. Arch Dis Child Fetal Neonatal Ed. 2012 Nov;97(6):F487-8.

Bate J, Chisholm J, Skinner R, Breuer J, Ramsay M, Wheatley K, Hambleton S, Heath PT. Varicella post-exposure prophylaxis in children with cancer: urgent need for a randomised controlled trial. Arch Dis Child 2012 Sep;97(9):853-4. 

Walker WT, de Whalley P, Andrews N, Oeser C, Casey M, Michaelis L, Hoschler K, Harrill C, Moulsdale P, Thompson B, Jones C, Chalk J, Kerridge S, John TM, Okike I, Ladhani S, Tomlinson R, Heath PT, Miller E, Faust SN, Snape MD, Finn A, Pollard AJ. H1N1 Antibody Persistence 1 Year After Immunization With an Adjuvanted or Whole-Virion Pandemic Vaccine and Immunogenicity and Reactogenicity of Subsequent Seasonal Influenza Vaccine: A Multicenter Follow-on Study. Clin Infect Dis 2012 Mar;54(5):661-669.

Patel SR, Bate J, Borrow R, Heath PT. Serotype-specific pneumococcal antibody concentrations in children treated for acute leukaemia. Arch Dis Child 2012 Jan;97(1):46-48.

de Whalley P, Walker W, Snape MD, Oeser C, Casey M, Moulsdale P, Harrill C, Andrews N, Hoschler K, Thompson B, Jones C, Chalk J, Kerridge S, Tomlinson R, Heath PT, Finn A, Faust S, Miller E, Pollard AJ. A 1-year follow-on study from a randomised, head-to-head, multicentre, open-label study of two pandemic influenza vaccines in children. Health Technol Assess. 2011 Dec;15(45):v-vi, xi-xiii, 1-128.

Shamez Ladhani, Clarissa Oeser, Joanne Sheldon, Mary Ramsay, Robert Booy, Paul T. Heath. Immunoglobulin Deficiency in children with Hib vaccine failure. Vaccine. 2011 Nov 15;29(49):9137-40.

Key publications

Edmond KM, Kortsalioudaki C, Scott S, Schrag SJ, Zaidi AK, Cousens S, Heath PT. Group B streptococcal disease in infants aged younger than 3 months: systematic review and meta-analysis. Lancet 2012 Feb;379(9815):547-556.

Conterno LO, Heath PT. Seroprotection against serogroup C meningococcal disease. BMJ 2008 Jun 28;336(7659):1447-8.

Research group

Alison Kent – Research fellow and PhD student working on the development of a computer software tool to improve the use of gentamicin in neonates

Clarissa Oeser - Research fellow and PhD student doing research on the pharmacokinetics and safety or meropenem in infants below 90 days of age with meningitis

Ifeanyichukwu Okike - Research fellow and PhD student working on a national study of neonatal meningitis with a specific focus on their early management, seeking ways to improve their outcomes

Hannah Keeble – Research fellow

Stefania Vergnano – Honorary research fellow

Chrissie Jones – Clinical lecturer

Jessica Bate - Research fellow

Gloria Kamba - Research nurse

Elia Vitale – Research nurse

Sue Baden – Senior Research Nurse Vaccine Institute

Tatiana Munera – Project manager

Hana Tabusa – Administrator

Collaborations

Public Health England

UK Paediatric Vaccines Group (UKPVG).

Neonatal infection network(neonIN).

PENTA Foundation

UK Neonatal Units

Dr Tim Planche (St George’s, University of London) – Microbiologist

Nigel Kennea (St George’s, University of London) – Neonatologist

Dr Shamez Ladhani – Senior lecturer in paediatric infectious diseases

Prof Ian Wong (Hong Kong University) – Professor of paediatric pharmacy

Funding

Novartis - Investigation of the feasibility of PCR for diagnosis of neonatal sepsis with Group B Streptococcus (GBS) and Escherichia coli (E. coli) - principal investigator July 2008 - August 2011. £57,292

Novartis - V72P12 - principal investigator November 2008 - May 2011. £27,7160.

National Institute for Health Research (NIHR) - H1N1 - principal investigator November 2009 - March 2010. £50,297.

GlaxoSmithKline (GSK) - Study in healthy children of GSK Biologicals - principal investigator - May 2009 - October 2010. £ 7,026.

Pfizer - PCV13 Sickle Cell Study - principal investigator -     October 2009 - June 2012. £ 18,199.

Gilead Sciences - neoFUNGAL- principal investigator -   June 2010 June 2011.  £ 16,735

NIHR - H1N1 follow on - principal investigator - November 2010 -  November 2011. £ 67,348.

Novartis - V72_29 N. meningitidis in Young Adults - principal investigator - September 2010 - February 2012. £ 367,080

Novartis - V72P12E1 - principal investigator - January 2010 -  May 2012.  £ 53,432.

Pfizer - Meningococcal carriage in young adults - principal investigator - February 2011 - May 2012. £ 308,328.

Pfizer - Meningitis Pilot - principal investigator - June 2011 - May 2012. £ 10,700.

Medical Research Foundation - Neomen - clinical investigator    December 2010 - June 2013. £ 123,192.

NIHR - 'Malta' - Can we reduce the number of vaccinations given to children? principal investigator February 2011- February 2013. £ 11,500.

GSK -GSK 004 Flu Study - principal investigator -  October 2011 - July 2013. £ 99,322

GSK -   GSK 009 Flu Study - principal investigator -  October 2012 - October 2013. £ 20,180.

Sanofi Pasteur - PRI01C - principal investigator -  April 2012 - September 2013. £121,834.

European Commission - Neomero - clinical investigator - January 2010 - December 2014. £ 499,869.

Pfizer - PUNS - clinical investigator - April 2012 - April 2014. £ 312,599.

Action Medical Research - Neogent - clinical investigator - August 2012 - July 2014. £ 86,084.NIHR    PEPtalk2    CI    01/12/2012 30/11/2014    24     £ 177,901

Novartis -  V72P12E2 - principal investigator - March 2013 September 2013. £ 27,770.

Medical Research Foundation - GBS - clinical investigator - July 2013 - September 2014. £ 150,385.

Medical Research Foundation -  CHIMES - principal investigator - March 2013 - April 2016. £ 69,278.

Pfizer - MEMENTO - principal investigator - August 2013
January 2015. £ 131,321.

European Commission -  NeoVanc - clinical investigator - January 2014 - December 2018. £ 554,608